INT60571

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Context Info
Confidence 0.45
First Reported 1993
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 3.76
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Gsta4)
Anatomy Link Frequency
liver 2
bladder 1
Gsta4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 8 95.44 Very High Very High Very High
Morphine 2 91.64 High High
alcohol 78 88.92 High High
Inflammation 66 87.76 High High
Paracetamol 5 86.40 High High
fibrosis 19 68.56 Quite High
cytokine 11 60.08 Quite High
Bile 2 55.60 Quite High
Nicotine 1 50.16 Quite High
Inflammatory response 8 41.64 Quite Low
Disease Link Frequency Relevance Heat
Stress 44 99.98 Very High Very High Very High
Obesity 12 98.80 Very High Very High Very High
Toxicity 12 93.04 High High
Prostate Cancer 84 88.92 High High
INFLAMMATION 77 87.76 High High
Hepatitis C Virus Infection 8 87.48 High High
Injury 31 76.64 Quite High
Hyperlipidemia 1 76.64 Quite High
Periodontitis 3 76.56 Quite High
Heart Rate Under Development 1 75.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The kidney, for instance, showed little induction of the glutathione transferases, while the GSTs were readily induced in the liver, bladder and prostate.
Neg (little) Positive_regulation (induction) of glutathione transferase in bladder
1) Confidence 0.45 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1421427 Disease Relevance 0.24 Pain Relevance 0
Similar increases in glutathione transferase activities were observed in animals of both phenotypes after phenobarbital treatment.
Positive_regulation (increases) of glutathione transferase
2) Confidence 0.36 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8510012 Disease Relevance 0.84 Pain Relevance 0.51
Activities of serum glutathione reductase, glutathione transferase and catalase and hepatic glutathione reductase in normal rats and serum glutathione peroxidase in hypercholesterolemic rats were enhanced by dietary spice principles.
Positive_regulation (enhanced) of glutathione transferase
3) Confidence 0.29 Published 2007 Journal Lipids Section Abstract Doc Link 17960446 Disease Relevance 0.08 Pain Relevance 0.48
The kidney, for instance, showed little induction of the glutathione transferases, while the GSTs were readily induced in the liver, bladder and prostate.
Neg (little) Positive_regulation (induction) of glutathione transferase in liver
4) Confidence 0.15 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1421427 Disease Relevance 0.24 Pain Relevance 0
Rats treated with CCl4 showed significant hepatic damage as observed from increase in serum enzymes (SGOT, SGPT, LDH, ALP) and lipid peroxidation [Figures 1–3] and depletion of glutathione (GSH), catalase, glutathione peroxidase, glutathione reductase, and increase in glutathione transferase [Figures 4–6].
Positive_regulation (increase) of glutathione transferase
5) Confidence 0.10 Published 2010 Journal Journal of Pharmacy and Bioallied Sciences Section Body Doc Link PMC2996063 Disease Relevance 0 Pain Relevance 0.03
Lowered catalase activity in CCl4 -treated groups could be due to increased superoxide anions as superoxide anions have been shown to inhibit catalase activity.[25] The elevated level of glutathione transferase (GSH-T) activity may increase glutathione (GSH) synthesis in order to counteract CCl4 -induced oxidative stress.
Positive_regulation (elevated) of glutathione transferase associated with stress
6) Confidence 0.10 Published 2010 Journal Journal of Pharmacy and Bioallied Sciences Section Body Doc Link PMC2996063 Disease Relevance 0.28 Pain Relevance 0.04
There was attenuation of ROS accumulation in response to the Gb extract, reduction in the transcription of stress inducible catalase genes and glutathione S-transferase 4, demonstrating its ability to combat oxidative stress [91].
Positive_regulation (inducible) of glutathione S-transferase 4 associated with stress
7) Confidence 0.08 Published 2008 Journal The Open Dentistry Journal Section Body Doc Link PMC2581528 Disease Relevance 1.03 Pain Relevance 0.10
All four compounds resulted in significantly higher total glutathione transferase enzymatic activity in the livers of treated animals compared to controls, and sulforaphane produced the greatest elevation (Figure 2B and Table 3).
Positive_regulation (resulted) of glutathione transferase in livers
8) Confidence 0.08 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1421427 Disease Relevance 0 Pain Relevance 0
These mechanisms include enzymes like SOD (Superoxide Dismutase), catalase, glutathione peroxidase (which removes H2O2), glutathione transferase, ferritine (removes metals like iron that promotes oxidative stress), and low molecular weight antioxidants such as vitamin E, vitamin C, vitamin A, uric acid, and bulirubin.
Positive_regulation (enzymes) of glutathione transferase associated with stress
9) Confidence 0.01 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2898022 Disease Relevance 1.05 Pain Relevance 0.29

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