INT60575

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Context Info
Confidence 0.26
First Reported 1993
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 12
Disease Relevance 2.09
Pain Relevance 4.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Fkbp1a) protein folding (Fkbp1a) cytosol (Fkbp1a)
signal transduction (Fkbp1a) enzyme binding (Fkbp1a) cytoplasm (Fkbp1a)
Anatomy Link Frequency
T cells 2
muscle 1
neurons 1
Fkbp1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 9 99.30 Very High Very High Very High
tetrodotoxin 4 98.54 Very High Very High Very High
qutenza 117 93.52 High High
Hyperalgesia 84 92.32 High High
agonist 24 81.96 Quite High
withdrawal 42 72.96 Quite High
nociceptor 123 71.24 Quite High
corticosteroid 148 31.40 Quite Low
Hippocampus 25 21.52 Low Low
long-term potentiation 9 12.40 Low Low
Disease Link Frequency Relevance Heat
Hyperalgesia 93 92.32 High High
Organ Transplantation 20 75.40 Quite High
Autoimmune Disease 4 65.00 Quite High
Fungal Infection 8 57.52 Quite High
Disease 33 30.16 Quite Low
Hepatitis C Virus Infection 208 26.80 Quite Low
Hepatitis 20 5.20 Low Low
Recurrence 92 5.00 Very Low Very Low Very Low
Nephrotoxicity 52 5.00 Very Low Very Low Very Low
INFLAMMATION 52 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is mainly due to the fact that for rapamycin to be active biologically, it must form a ternary complex with mTOR and FKBP12 (FK506-binding protein 12 kDa), a small cytosolic protein receptor.
FKBP12 Binding (complex) of
1) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0
To confirm the specificity of the action of rapamycin on mTOR, we used ascomycin, an analog of FK506, which binds to FKBP12 but does not inhibit mTOR activity [43].
FKBP12 Binding (binds) of
2) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0.45 Pain Relevance 1.10
It has been shown that rapamycin forms a complex with the immunophilin FK506-binding protein 12 (FKBP12), which then inhibits the protein kinase activity of mTOR.
FKBP12 Binding (complex) of
3) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0.57 Pain Relevance 1.19
It has been shown that rapamycin forms a complex with the immunophilin FK506-binding protein 12 (FKBP12), which then inhibits the protein kinase activity of mTOR.
FKBP12 Binding (forms) of
4) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0.57 Pain Relevance 1.20
Sirolimus which also binds to the FKBP family, particularly FKBP-12, does not bind to calcineurin but instead binds to target molecules with kinase activity called MTOR (mammalian targets of rapamycin), also known as FRAP and RAFT.
FKBP-12 Binding (binds) of
5) Confidence 0.04 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.05 Pain Relevance 0
Sirolimus which also binds to the FKBP family, particularly FKBP-12, does not bind to calcineurin but instead binds to target molecules with kinase activity called MTOR (mammalian targets of rapamycin), also known as FRAP and RAFT.
FKBP-12 Neg (not) Binding (bind) of
6) Confidence 0.03 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.05 Pain Relevance 0
Despite the structural homology between sirolimus and tacrolimus with both drugs binding to the same intracellular immunophilin, FK506 binding protein, a 12-kDa binding protein (FK Binding protein-12) in T cells, the two drugs act synergistically rather than competitively and also differ in their mechanism of action.
FK Binding protein-12 Binding (binding) of in T cells
7) Confidence 0.03 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.20 Pain Relevance 0
Despite the structural homology between sirolimus and tacrolimus with both drugs binding to the same intracellular immunophilin, FK506 binding protein, a 12-kDa binding protein (FK Binding protein-12) in T cells, the two drugs act synergistically rather than competitively and also differ in their mechanism of action.
FK Binding protein-12 Binding (binding) of in T cells
8) Confidence 0.03 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.19 Pain Relevance 0
Indirect immunofluorescence staining demonstrated that FK1 binds to the hippocampal neurons, as would be expected based on the high degree of homology among nAChR alpha subunits from diverse sources in the region surrounding Lys-125.
FK1 Binding (binds) of in neurons
9) Confidence 0.02 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8510023 Disease Relevance 0 Pain Relevance 0.24
PHY prevented the binding of FK1, thus supporting that FK1 is a specific probe for the PHY site.
FK1 Binding (binding) of
10) Confidence 0.02 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8510023 Disease Relevance 0 Pain Relevance 0.23
PHY prevented the binding of FK1, thus supporting that FK1 is a specific probe for the PHY site.
FK1 Binding (binding) of
11) Confidence 0.02 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8510023 Disease Relevance 0 Pain Relevance 0.24
This action was insensitive to DL-2-amino-5-phosphonovaleric acid, atropine, tetrodotoxin and competitive nicotinic antagonists, but blocked by benzoquinonium or FK1, a nAChR-specific antibody raised against rat muscle nAChR alpha subunits that binds to the novel site.
FK1 Binding (binds) of in muscle associated with tetrodotoxin and antagonist
12) Confidence 0.01 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8510023 Disease Relevance 0 Pain Relevance 0.25

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