INT6058

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Context Info
Confidence 0.81
First Reported 1990
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 73
Total Number 75
Disease Relevance 16.70
Pain Relevance 30.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Fos) nucleolus (Fos) nucleus (Fos)
DNA binding (Fos) transcription factor binding (Fos) response to stress (Fos)
Anatomy Link Frequency
neurons 10
brain 5
spinal cord 3
brainstem 3
dorsal horn 3
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 113 100.00 Very High Very High Very High
Kinase C 22 100.00 Very High Very High Very High
Thalamus 19 100.00 Very High Very High Very High
Hippocampus 17 100.00 Very High Very High Very High
c fibre 12 100.00 Very High Very High Very High
nociceptor 14 99.90 Very High Very High Very High
intrathecal 6 99.72 Very High Very High Very High
Ventral tegmentum 6 99.68 Very High Very High Very High
amygdala 19 99.66 Very High Very High Very High
antagonist 63 99.62 Very High Very High Very High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 306 100.00 Very High Very High Very High
Urological Neuroanatomy 95 99.80 Very High Very High Very High
Opiate Addiction 1 99.42 Very High Very High Very High
INFLAMMATION 60 99.26 Very High Very High Very High
Body Weight 4 99.24 Very High Very High Very High
Neuropathic Pain 21 99.12 Very High Very High Very High
Hemorrhage 9 98.72 Very High Very High Very High
Injury 30 98.28 Very High Very High Very High
Primary Sclerosing Cholangitis 168 97.88 Very High Very High Very High
Nociception 48 97.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to determine if there is a relationship between withdrawal-induced neuronal activity and conditioned place aversion, immunocytochemical localization of Fos was examined in the basal forebrain of opiate-dependent animals receiving one of several doses of naloxone (0, 3.25, 7.5, 15, 30, or 1000 microg/kg).
Localization (localization) of Fos in forebrain associated with narcan, opiate and withdrawal
1) Confidence 0.81 Published 2001 Journal Neuropsychopharmacology Section Abstract Doc Link 11120397 Disease Relevance 0 Pain Relevance 1.27
Immunocytochemical localization of Fos was used as our metric for "sound activation."
Localization (localization) of Fos
2) Confidence 0.80 Published 2005 Journal Neuroscience Section Abstract Doc Link 16344157 Disease Relevance 0 Pain Relevance 0
The Fos-LIR was co-localized with tyrosine hydroxylase immunoreactivity in many of the cells in caudal and rostral ventrolateral medulla, A5 and locus coeruleus.
Localization (localized) of Fos-LIR in locus coeruleus associated with rostral ventrolateral medulla and locus ceruleus
3) Confidence 0.80 Published 1993 Journal Brain Res. Section Abstract Doc Link 7902768 Disease Relevance 0 Pain Relevance 1.17
Immunohistochemical localization of Fos protein was used to examine the neuronal activation, and the combination of Fos immunohistochemistry with the retrograde labeling of Fluoro-Gold (FG) injected into the ventrobasal complex of the thalamus was used to characterize the activated neurons.
Localization (localization) of Fos in neuronal associated with thalamus
4) Confidence 0.80 Published 2001 Journal Brain Res. Section Abstract Doc Link 11259778 Disease Relevance 0.39 Pain Relevance 0.36
By 1 h, Fos was predominantly localized in subdivisions of the IO contralateral to TTX treatment.
Localization (localized) of Fos associated with tetrodotoxin
5) Confidence 0.79 Published 2003 Journal Brain Res. Section Abstract Doc Link 12646317 Disease Relevance 0 Pain Relevance 0.65
The differential pattern of Fos/NADPH-d colocalization across the nucleus suggests that midline and lateral wing NOS neurons of the DRN express their neuromodulatory actions on discrete efferent targets via different intracellular mechanisms.
Localization (colocalization) of Fos in DRN
6) Confidence 0.78 Published 2006 Journal Brain Res. Section Abstract Doc Link 16616732 Disease Relevance 0 Pain Relevance 0.46
Double-label immunocytochemistry revealed no co-localization of c-Fos and nNOS in any brain region.
Localization (localization) of c-Fos in brain
7) Confidence 0.78 Published 2001 Journal Brain Res. Bull. Section Abstract Doc Link 11275410 Disease Relevance 0 Pain Relevance 0.84
Additionally very little colocalization between NOS and c-fos following noxious stimulation was found.
Localization (colocalization) of c-fos
8) Confidence 0.78 Published 2001 Journal Brain Res. Section Abstract Doc Link 11146065 Disease Relevance 0 Pain Relevance 0.09
Double immunocytochemistry at the light microscopic level demonstrated co-localization of translocated PKC betaII and c-Fos in some cortical neurons 90 min after morphine injection.
Localization (translocated) of c-Fos in neurons associated with kinase c and morphine
9) Confidence 0.78 Published 2004 Journal Brain Res. Bull. Section Abstract Doc Link 14709343 Disease Relevance 0 Pain Relevance 1.42
Neuronal activation was quantified by localization of (35)S-labeled probe for the immediate early gene, c-fos.
Localization (localization) of c-fos in Neuronal
10) Confidence 0.78 Published 2006 Journal J. Comp. Neurol. Section Abstract Doc Link 16739166 Disease Relevance 0.16 Pain Relevance 0.71
Immunocytochemical localization of the c-fos primary gene protein, Fos, was used to identify spinal cord and brain-stem sites activated by either 4-Hz or 100-Hz electroacupuncture (EA) applied to the Zusanli acupuncture points of both hind limbs in lightly anesthetized Sprague-Dawley rats.
Localization (localization) of Fos in hind limbs associated with acupuncture, electroacupuncture and spinal cord
11) Confidence 0.75 Published 1993 Journal Pain Section Abstract Doc Link 8446432 Disease Relevance 0 Pain Relevance 0.60
The number of immunocytochemically stained Fos-positive cells and the immunoprecipitation of the Fos antibodies were reduced by pretreatment, and were also reduced, to a lesser extent, by post-treatment.
Localization (immunoprecipitation) of Fos
12) Confidence 0.75 Published 1998 Journal Anesthesiology Section Body Doc Link 9447868 Disease Relevance 0.07 Pain Relevance 0
This experiment investigated the influence of age on prefrontal acetylcholine (ACh) release and Fos response in the hypothalamic paraventricular nucleus and the nucleus tractus solitarius (NTS) of rats following isoflurane anesthesia.
Localization (response) of Fos in prefrontal associated with anesthesia and isoflurane
13) Confidence 0.75 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530892 Disease Relevance 0 Pain Relevance 0.33
The Fos-LIR was co-localized with tyrosine hydroxylase immunoreactivity in many of the cells in caudal and rostral ventrolateral medulla, A5 and locus coeruleus.
Localization (co-localized) of Fos-LIR in locus coeruleus associated with rostral ventrolateral medulla and locus ceruleus
14) Confidence 0.75 Published 1993 Journal Brain Res. Section Abstract Doc Link 7902768 Disease Relevance 0 Pain Relevance 1.17
Colocalization of Fos- and glucocorticoid receptor-immunoreactivities is present only in a very restricted population of dorsal horn neurons of the rat spinal cord after nociceptive stimulation.
Localization (Colocalization) of Fos in dorsal horn associated with nociception, pain, dorsal horn neuron and spinal cord
15) Confidence 0.75 Published 1993 Journal Brain Res. Section Title Doc Link 8149241 Disease Relevance 0.18 Pain Relevance 0.46
One and two hours after i.pl. formalin injection, c-Fos immunoreactive (c-Fos-IR) nuclei were preferentially located in the superficial (I-II) and deep (V-VI) laminae of the spinal dorsal horn of segments L4-L5, i.e. spinal areas containing numerous neurons responding exclusively, or not, to peripheral nociceptive stimuli.
Localization (located) of c-Fos-IR in dorsal horn associated with nociception and spinal dorsal horn
16) Confidence 0.74 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12007921 Disease Relevance 0.26 Pain Relevance 0.05
Patterns of neuronal activity in the lumbar spinal cord of the anaesthetized rat were mapped by immunocytochemical localization of the c-fos gene product, Fos protein, at different timepoints following brief noxious stimulation of one hindpaw (20 s immersion in water at 52 degrees C).
Localization (localization) of Fos in spinal cord associated with spinal cord
17) Confidence 0.74 Published 1990 Journal Neuroscience Section Abstract Doc Link 2215924 Disease Relevance 0 Pain Relevance 0.12
Expression of NADPH-diaphorase and colocalization with Fos in the brain neurons of the rat following visceral noxious stimulation.
Localization (colocalization) of Fos in brain associated with pain
18) Confidence 0.74 Published 1999 Journal Brain Res. Section Title Doc Link 10407110 Disease Relevance 0 Pain Relevance 0.26
At segments of L1-2 and S1-3, Fos-ir labelings were diffusely and symmetrically distributed on both sides of the gray matter; however, at L4-5 segments, Fos-ir neurons were densely localized in medial portion of laminae I-II, less densely in laminae V-VI and a few in laminae VII and X ipsilateral to the injection side.
Localization (localized) of Fos in medial
19) Confidence 0.73 Published 1998 Journal Brain Res. Section Abstract Doc Link 9739136 Disease Relevance 0.16 Pain Relevance 0.32
Immunoneutralization of c-Fos using intrathecal antibody electroporation attenuates chronic constrictive injury-induced hyperalgesia and regulates preprodynorphin expression in rats.
Localization (Immunoneutralization) of c-Fos associated with hyperalgesia, injury and intrathecal
20) Confidence 0.73 Published 2003 Journal Anesthesiology Section Title Doc Link 14508329 Disease Relevance 0.19 Pain Relevance 0.23

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