INT60585

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 1993
Last Reported 2011
Negated 6
Speculated 4
Reported most in Body
Documents 59
Total Number 63
Disease Relevance 54.55
Pain Relevance 5.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TP53) nucleoplasm (TP53) mitochondrion (TP53)
endoplasmic reticulum (TP53) enzyme binding (TP53) protein complex assembly (TP53)
Anatomy Link Frequency
neuronal 2
null cells 2
plasma 1
lymphocyte 1
skin 1
TP53 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 285 99.80 Very High Very High Very High
Kinase C 20 99.74 Very High Very High Very High
rheumatoid arthritis 71 98.00 Very High Very High Very High
Inflammation 251 97.84 Very High Very High Very High
Chronic pancreatitis 9 97.60 Very High Very High Very High
aspirin 39 97.28 Very High Very High Very High
methotrexate 30 96.64 Very High Very High Very High
Pain 23 96.48 Very High Very High Very High
Arthritis 218 96.16 Very High Very High Very High
tetrodotoxin 4 94.00 High High
Disease Link Frequency Relevance Heat
Cancer 2658 100.00 Very High Very High Very High
Apoptosis 834 100.00 Very High Very High Very High
Li-fraumeni Syndrome 35 100.00 Very High Very High Very High
Paraganglioma 17 99.84 Very High Very High Very High
Stomach Cancer 42 99.76 Very High Very High Very High
Familial Adenomatous Polyposis 27 99.76 Very High Very High Very High
Aneuploidy 28 99.74 Very High Very High Very High
Stress 95 99.68 Very High Very High Very High
Inflammatory Breast Neoplasms 266 99.66 Very High Very High Very High
Breast Cancer 1103 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The antitumor effects thereby depend on the expression level of transduced p53 and on the integrity in p53-mediated cascades in the target tumors.
Regulation (depend) of p53 associated with cancer
1) Confidence 0.59 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761194 Disease Relevance 0.63 Pain Relevance 0
Zeimet and Marth (2003) suggested that tumors with epigenetically deregulated the p53 gene also showed the similar responses to Ad-p53 as found in the tumors with a dominant-negative p53 mutation.


Regulation (deregulated) of p53 associated with cancer
2) Confidence 0.59 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761194 Disease Relevance 0.57 Pain Relevance 0
We identified the regulation of apoptosis-responsive genes, bcl-2, caspase-3 and p53 after combined treatment.
Regulation (regulation) of p53 associated with apoptosis
3) Confidence 0.53 Published 2003 Journal Cancer Lett. Section Abstract Doc Link 12490308 Disease Relevance 0.68 Pain Relevance 0.43
No any change in mRNA p53 levels for 24 h was observed in HEP G2 cells (Figure 5).
Neg (No) Regulation (change) of p53
4) Confidence 0.48 Published 2002 Journal BMC Cancer Section Body Doc Link PMC101407 Disease Relevance 0.61 Pain Relevance 0
However, the treatment did not alter mRNA p53 levels as revealed by Northern blot analysis suggesting that apoptosis would be occurring through other mechanism, p53 independent.
Neg (not) Regulation (alter) of p53 associated with apoptosis
5) Confidence 0.48 Published 2002 Journal BMC Cancer Section Body Doc Link PMC101407 Disease Relevance 0.69 Pain Relevance 0.04
Eventually, neurons activated caspase 3 and PUMA (p53 up-regulated modulator of apoptosis), hallmarks of neuronal apoptosis, and died.
Regulation (regulated) of p53 in neuronal associated with neurodegenerative disease and apoptosis
6) Confidence 0.44 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19508430 Disease Relevance 0.34 Pain Relevance 0.38
These data support a role for p53 gene alterations in human pancreatic cancer, and suggest that loss of its regulatory functions may constitute one of the differences between pancreatic cancer and chronic pancreatitis.
Regulation (role) of p53 associated with pancreatic cancer and chronic pancreatitis
7) Confidence 0.43 Published 1993 Journal Cancer Lett. Section Abstract Doc Link 8513440 Disease Relevance 1.03 Pain Relevance 0.43
In addition, we demonstrated that the response to paclitaxel/RT was not affected by mutations in the p53 tumor suppressor gene.
Neg (not) Regulation (affected) of p53 associated with cancer
8) Confidence 0.42 Published 1997 Journal Front. Biosci. Section Abstract Doc Link 9206986 Disease Relevance 1.01 Pain Relevance 0.06
Previous reports have suggested that the regulation of p53 and p21 is HIF-1-dependent.
Regulation (regulation) of p53
9) Confidence 0.42 Published 2004 Journal Int. J. Cancer Section Abstract Doc Link 15170665 Disease Relevance 1.05 Pain Relevance 0
However, tumor cell proliferation through the regulation of COX-2 in gastric cancer may not be dependent on p53 status.



Neg (not) Spec (may) Regulation (dependent) of p53 associated with cancer and stomach cancer
10) Confidence 0.41 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721998 Disease Relevance 0.80 Pain Relevance 0
These novel molecular markers have been chosen from the viewpoint of involvement in the regulation of the p53 and RB tumor suppressor pathways, DNA damage response, and angiogenesis/metastasis, which play critical roles in human breast cancer development.
Regulation (regulation) of p53 associated with cancer, breast cancer and metastasis
11) Confidence 0.40 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 1.02 Pain Relevance 0
Increased NO production after treatment uniformly stimulated p53 and Bax expression through Mdm2 down-regulation in p53-WT cells, whereas all were unaffected in p53-null cells.
Regulation (regulation) of p53 in null cells
12) Confidence 0.40 Published 2009 Journal Anticancer Res. Section Abstract Doc Link 19846903 Disease Relevance 0.86 Pain Relevance 0.30
Increased NO production after treatment uniformly stimulated p53 and Bax expression through Mdm2 down-regulation in p53-WT cells, whereas all were unaffected in p53-null cells.
Neg (unaffected) Regulation (unaffected) of p53 in null cells
13) Confidence 0.40 Published 2009 Journal Anticancer Res. Section Abstract Doc Link 19846903 Disease Relevance 0.87 Pain Relevance 0.30
The TP53 tumor suppressor gene, which is located on chromosome 17, encodes the nuclear protein p53, which regulates proliferation of normal cells [8].
Regulation (located) of TP53 associated with cancer
14) Confidence 0.40 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410751 Disease Relevance 1.10 Pain Relevance 0
With regards to the TP53 gene, sequencing detected no mutations in either the patient's tumor or lymphocyte samples, or in the two control samples.
Regulation (regards) of TP53 in lymphocyte associated with cancer
15) Confidence 0.39 Published 2010 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2991767 Disease Relevance 0.76 Pain Relevance 0
Correlation of p53 Status and miRNA expression
Regulation (Correlation) of p53
16) Confidence 0.37 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.57 Pain Relevance 0
Therefore, we unfortunately have to conclude an immunohistochemical evaluation using bcl-2 or p53 in gangliocytic paraganglioma has a limited prognostic value mostly due to its rarity.
Regulation (using) of p53 associated with paraganglioma
17) Confidence 0.36 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2874790 Disease Relevance 1.18 Pain Relevance 0.04
To elucidate the mechanisms of ALA causing apoptosis selectively, we have examined the effect of ALA on p53 mRNA levels.
Spec (examined) Regulation (effect) of p53 mRNA associated with apoptosis
18) Confidence 0.36 Published 2002 Journal BMC Cancer Section Body Doc Link PMC101407 Disease Relevance 0.61 Pain Relevance 0
The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response.
Regulation (regulator) of p53 associated with stress, dna damage and cancer
19) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.74 Pain Relevance 0.17
The p53 pathway was also found to be affected by bucillamine, which, as said above, is mainly used as a treatment in Japan to reduce pain in RA patients [45].


Regulation (affected) of p53 associated with pain and arthritis
20) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.76 Pain Relevance 0.27

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox