INT60610

Context Info Confidence 0.26 First Reported 1993 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 7 Total Number 8 Disease Relevance 6.88 Pain Relevance 3.32

cytosol (Gsr) mitochondrion (Gsr) oxidoreductase activity (Gsr) cytoplasm (Gsr)

Anatomy Link Frequency neutrophils 2 lungs 1 Gsr (Mus musculus)

Pain Link Frequency Relevance Heat Arthritis 174 99.68 lidocaine 102 98.58 Inflammation 262 98.36 Pain 2 97.24 Paracetamol 11 97.12 rheumatoid arthritis 150 96.28 cytokine 62 80.04 chemokine 39 77.92 agonist 22 62.40 aspirin 4 53.60

Disease Link Frequency Relevance Heat Infection 227 99.90 Arthritis 168 99.68 Sprains And Strains 4 99.12 Mycobacterial Infection 292 98.40 INFLAMMATION 283 98.36 Disease 75 97.76 Apoptosis 20 97.56 Pain 4 97.24 Rheumatoid Arthritis 154 96.28 Injury 113 93.44

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Pretreatment with 1,3-bis(chloroethyl)-1-nitrosourea (BCNU) (0.1 mM) for 30 min, which irreversibly inhibited glutathione reductase (GSSG-Rd) activity, increased the extent of GSSG formation produced by APAP exposure and potentiated its cell killing.

Negative_regulation (inhibited) of glutathione reductase associated with paracetamol

1) Confidence 0.26 Published 1993 Journal Biochem. Pharmacol. Section Abstract Doc Link 8517869 Disease Relevance 0.22 Pain Relevance 0.77

Finally, depletion of Gr-1+ cells eliminates the effect of sH4.

Negative_regulation (depletion) of Gr-1

2) Confidence 0.12 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 0.90 Pain Relevance 0.22

In arthritis animal models, depletion of Gr-1+ neutrophils resulted in a decrease of arthritis severity [9]–[14].

Negative_regulation (depletion) of Gr-1 in neutrophils associated with arthritis

3) Confidence 0.12 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 1.80 Pain Relevance 0.75

Experimental infection and Gr1 depletion

Negative_regulation (depletion) of Gr1 associated with infection

4) Confidence 0.10 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 0.88 Pain Relevance 0.12

Interestingly, in vivo depletion of Gr1+ neutrophils between days 10–15 results in decreased accumulation of Th1 cells on day 21 in M.tuberculosis-infected lungs without impacting overall protective outcomes.

Negative_regulation (depletion) of Gr1 in lungs associated with mycobacterial infection

5) Confidence 0.10 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3020951 Disease Relevance 0.93 Pain Relevance 0.17

Peritoneal cells collected from mice receiving lidocaine (at both 0.08% and 0.008%) together with zymosan showed significantly decreased annexin-V+Gr-1+ cells by 50% and 64%, respectively, indicating reduced PMN apoptosis (Fig. 3A).

Negative_regulation (decreased) of Gr-1 associated with apoptosis and lidocaine

6) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.49 Pain Relevance 0.82

The decrease in Gr-1-positive cell count, which showed a larger effect for melatonin, is indeed a better indicator of the robust anti-inflammatory actions of melatonin than overall labeling intensity, as the former reflects the actual change in the total number of infiltrating Gr-1 immunopositive cells (presumably neutrophils) while the latter averages overall color intensity of cellular, non-cellular, and background labeling.

Negative_regulation (decrease) of Gr-1 in neutrophils associated with inflammation

7) Confidence 0.01 Published 2010 Journal International Journal of Biological Sciences Section Body Doc Link PMC2878173 Disease Relevance 0.79 Pain Relevance 0.24

Here, we quantified and statistically analyzed the degree of inflammation and found approximately 40% drop in Gr-1 immunopositive cell counts and over 20% decrease in Gr-1 labeling intensity (Fig. 3) both of which were statistically significant (p<0.01, N=3 to 7).

Negative_regulation (decrease) of Gr-1 associated with inflammation

8) Confidence 0.01 Published 2010 Journal International Journal of Biological Sciences Section Body Doc Link PMC2878173 Disease Relevance 0.86 Pain Relevance 0.24

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