INT60610

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.26
First Reported 1993
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 6.88
Pain Relevance 3.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gsr) mitochondrion (Gsr) oxidoreductase activity (Gsr)
cytoplasm (Gsr)
Anatomy Link Frequency
neutrophils 2
lungs 1
Gsr (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 174 99.68 Very High Very High Very High
lidocaine 102 98.58 Very High Very High Very High
Inflammation 262 98.36 Very High Very High Very High
Pain 2 97.24 Very High Very High Very High
Paracetamol 11 97.12 Very High Very High Very High
rheumatoid arthritis 150 96.28 Very High Very High Very High
cytokine 62 80.04 Quite High
chemokine 39 77.92 Quite High
agonist 22 62.40 Quite High
aspirin 4 53.60 Quite High
Disease Link Frequency Relevance Heat
Infection 227 99.90 Very High Very High Very High
Arthritis 168 99.68 Very High Very High Very High
Sprains And Strains 4 99.12 Very High Very High Very High
Mycobacterial Infection 292 98.40 Very High Very High Very High
INFLAMMATION 283 98.36 Very High Very High Very High
Disease 75 97.76 Very High Very High Very High
Apoptosis 20 97.56 Very High Very High Very High
Pain 4 97.24 Very High Very High Very High
Rheumatoid Arthritis 154 96.28 Very High Very High Very High
Injury 113 93.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with 1,3-bis(chloroethyl)-1-nitrosourea (BCNU) (0.1 mM) for 30 min, which irreversibly inhibited glutathione reductase (GSSG-Rd) activity, increased the extent of GSSG formation produced by APAP exposure and potentiated its cell killing.
Negative_regulation (inhibited) of glutathione reductase associated with paracetamol
1) Confidence 0.26 Published 1993 Journal Biochem. Pharmacol. Section Abstract Doc Link 8517869 Disease Relevance 0.22 Pain Relevance 0.77
Finally, depletion of Gr-1+ cells eliminates the effect of sH4.
Negative_regulation (depletion) of Gr-1
2) Confidence 0.12 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 0.90 Pain Relevance 0.22
In arthritis animal models, depletion of Gr-1+ neutrophils resulted in a decrease of arthritis severity [9]–[14].
Negative_regulation (depletion) of Gr-1 in neutrophils associated with arthritis
3) Confidence 0.12 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 1.80 Pain Relevance 0.75
Experimental infection and Gr1 depletion
Negative_regulation (depletion) of Gr1 associated with infection
4) Confidence 0.10 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 0.88 Pain Relevance 0.12
Interestingly, in vivo depletion of Gr1+ neutrophils between days 10–15 results in decreased accumulation of Th1 cells on day 21 in M.tuberculosis-infected lungs without impacting overall protective outcomes.
Negative_regulation (depletion) of Gr1 in lungs associated with mycobacterial infection
5) Confidence 0.10 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3020951 Disease Relevance 0.93 Pain Relevance 0.17
Peritoneal cells collected from mice receiving lidocaine (at both 0.08% and 0.008%) together with zymosan showed significantly decreased annexin-V+Gr-1+ cells by 50% and 64%, respectively, indicating reduced PMN apoptosis (Fig. 3A).
Negative_regulation (decreased) of Gr-1 associated with apoptosis and lidocaine
6) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.49 Pain Relevance 0.82
The decrease in Gr-1-positive cell count, which showed a larger effect for melatonin, is indeed a better indicator of the robust anti-inflammatory actions of melatonin than overall labeling intensity, as the former reflects the actual change in the total number of infiltrating Gr-1 immunopositive cells (presumably neutrophils) while the latter averages overall color intensity of cellular, non-cellular, and background labeling.
Negative_regulation (decrease) of Gr-1 in neutrophils associated with inflammation
7) Confidence 0.01 Published 2010 Journal International Journal of Biological Sciences Section Body Doc Link PMC2878173 Disease Relevance 0.79 Pain Relevance 0.24
Here, we quantified and statistically analyzed the degree of inflammation and found approximately 40% drop in Gr-1 immunopositive cell counts and over 20% decrease in Gr-1 labeling intensity (Fig. 3) both of which were statistically significant (p<0.01, N=3 to 7).
Negative_regulation (decrease) of Gr-1 associated with inflammation
8) Confidence 0.01 Published 2010 Journal International Journal of Biological Sciences Section Body Doc Link PMC2878173 Disease Relevance 0.86 Pain Relevance 0.24

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox