INT60626

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Context Info
Confidence 0.54
First Reported 1995
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 2.30
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh, Pomc) extracellular region (Crh, Pomc) cytoplasm (Crh, Pomc)
signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) cell-cell signaling (Pomc)
Anatomy Link Frequency
pituitary 4
anterior pituitary 2
Crh (Mus musculus)
Pomc (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 2 99.16 Very High Very High Very High
Pain 2 98.56 Very High Very High Very High
Opioid 8 86.92 High High
Dopamine 4 84.84 Quite High
alcohol 8 83.36 Quite High
addiction 4 81.36 Quite High
Neuropeptide 20 80.56 Quite High
depression 6 79.36 Quite High
antidepressant 6 75.00 Quite High
Neurotransmitter 4 69.84 Quite High
Disease Link Frequency Relevance Heat
Stress 60 99.08 Very High Very High Very High
INFLAMMATION 8 98.76 Very High Very High Very High
Pain 2 98.56 Very High Very High Very High
Increased Venous Pressure Under Development 2 97.20 Very High Very High Very High
Pituitary Cancer 4 95.16 Very High Very High Very High
Frailty 4 84.64 Quite High
Alcohol Addiction 4 81.36 Quite High
Depression 6 79.36 Quite High
Targeted Disruption 30 75.76 Quite High
Anxiety Disorder 8 34.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In times of stress the hypothalamic-pituitary-adrenal (HPA) axis is activated and releases two neurohormones, corticotropin-releasing hormone (Crh) and arginine vasopressin (Avp), to synergistically stimulate the secretion of adrenocorticotropin hormone (ACTH) from the anterior pituitary, culminating in a rise in circulating glucocorticoids.
corticotropin-releasing hormone Positive_regulation (stimulate) of Localization (secretion) of ACTH in pituitary associated with stress
1) Confidence 0.54 Published 2008 Journal Psychoneuroendocrinology Section Abstract Doc Link 18243568 Disease Relevance 0.26 Pain Relevance 0.21
The basal secretion of adrenocorticotropin (ACTH) as well as the corticotropin-releasing factor (CRF)-stimulated ACTH released remained unchanged after R(+)- and S(-)-SAL treatment.
corticotropin-releasing factor Positive_regulation (-stimulated) of Localization (secretion) of ACTH
2) Confidence 0.52 Published 1995 Journal Alcohol Section Abstract Doc Link 8519440 Disease Relevance 0.18 Pain Relevance 0.32
The basal secretion of adrenocorticotropin (ACTH) as well as the corticotropin-releasing factor (CRF)-stimulated ACTH released remained unchanged after R(+)- and S(-)-SAL treatment.
corticotropin-releasing factor Positive_regulation (-stimulated) of Localization (secretion) of ACTH
3) Confidence 0.52 Published 1995 Journal Alcohol Section Abstract Doc Link 8519440 Disease Relevance 0.18 Pain Relevance 0.32
The basal secretion of adrenocorticotropin (ACTH) as well as the corticotropin-releasing factor (CRF)-stimulated ACTH released remained unchanged after R(+)- and S(-)-SAL treatment.
corticotropin-releasing factor Positive_regulation (-stimulated) of Localization (secretion) of ACTH
4) Confidence 0.52 Published 1995 Journal Alcohol Section Abstract Doc Link 8519440 Disease Relevance 0.18 Pain Relevance 0.32
The basal secretion of adrenocorticotropin (ACTH) as well as the corticotropin-releasing factor (CRF)-stimulated ACTH released remained unchanged after R(+)- and S(-)-SAL treatment.
corticotropin-releasing factor Positive_regulation (-stimulated) of Localization (released) of ACTH
5) Confidence 0.52 Published 1995 Journal Alcohol Section Abstract Doc Link 8519440 Disease Relevance 0.17 Pain Relevance 0.32
In times of stress the hypothalamic-pituitary-adrenal (HPA) axis is activated and releases two neurohormones, corticotropin-releasing hormone (Crh) and arginine vasopressin (Avp), to synergistically stimulate the secretion of adrenocorticotropin hormone (ACTH) from the anterior pituitary, culminating in a rise in circulating glucocorticoids.
Crh Positive_regulation (stimulate) of Localization (secretion) of ACTH in pituitary associated with stress
6) Confidence 0.36 Published 2008 Journal Psychoneuroendocrinology Section Abstract Doc Link 18243568 Disease Relevance 0.26 Pain Relevance 0.21
On the other hand, CRH stimulates the rapid release of adrenocorticotropic hormone (ACTH) from the anterior pituitary (Rivier and Plotsky, 1986; Orth, 1992).
CRH Positive_regulation (stimulates) of Localization (release) of ACTH in anterior pituitary
7) Confidence 0.22 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.37 Pain Relevance 0.16
This result indicates that CRH plays an indispensable role in the induction of the ACTH release, especially under the stress condition.
CRH Positive_regulation (induction) of Localization (release) of ACTH associated with stress
8) Confidence 0.15 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.71 Pain Relevance 0.13

General Comments

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