INT60627

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Context Info
Confidence 0.11
First Reported 1995
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.44
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Mc2r) extracellular space (Crh) extracellular region (Crh)
plasma membrane (Mc2r) signal transducer activity (Mc2r) response to stress (Crh)
Anatomy Link Frequency
pituitary 2
Crh (Mus musculus)
Mc2r (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 2 86.92 High High
Dopamine 1 84.84 Quite High
alcohol 2 83.36 Quite High
addiction 1 81.36 Quite High
depression 1 78.88 Quite High
antidepressant 3 75.00 Quite High
sSRI 3 68.48 Quite High
tricyclic antidepressant 3 64.40 Quite High
fluoxetine 5 46.56 Quite Low
Desipramine 2 44.08 Quite Low
Disease Link Frequency Relevance Heat
Stress 2 98.16 Very High Very High Very High
Pituitary Cancer 1 95.16 Very High Very High Very High
Alcohol Addiction 1 81.36 Quite High
Depression 1 78.88 Quite High
Targeted Disruption 5 30.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The basal secretion of adrenocorticotropin (ACTH) as well as the corticotropin-releasing factor (CRF)-stimulated ACTH released remained unchanged after R(+)- and S(-)-SAL treatment.
corticotropin-releasing factor Positive_regulation (-stimulated) of Localization (secretion) of adrenocorticotropin
1) Confidence 0.11 Published 1995 Journal Alcohol Section Abstract Doc Link 8519440 Disease Relevance 0.18 Pain Relevance 0.32
In times of stress the hypothalamic-pituitary-adrenal (HPA) axis is activated and releases two neurohormones, corticotropin-releasing hormone (Crh) and arginine vasopressin (Avp), to synergistically stimulate the secretion of adrenocorticotropin hormone (ACTH) from the anterior pituitary, culminating in a rise in circulating glucocorticoids.
corticotropin-releasing hormone Positive_regulation (stimulate) of Localization (secretion) of adrenocorticotropin hormone in pituitary associated with stress
2) Confidence 0.08 Published 2008 Journal Psychoneuroendocrinology Section Abstract Doc Link 18243568 Disease Relevance 0.26 Pain Relevance 0.21

General Comments

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