INT6063

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Context Info
Confidence 0.66
First Reported 1990
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 17
Total Number 18
Disease Relevance 6.07
Pain Relevance 3.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Bche) endoplasmic reticulum (Bche)
Anatomy Link Frequency
brain 2
terminal Schwann cells 2
plasma 1
cerebrospinal fluid 1
central nervous system 1
Bche (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 12 100.00 Very High Very High Very High
Pain 5 100.00 Very High Very High Very High
Central nervous system 4 100.00 Very High Very High Very High
anesthesia 2 99.40 Very High Very High Very High
sSRI 96 99.36 Very High Very High Very High
Serotonin 15 99.36 Very High Very High Very High
cerebral cortex 2 99.36 Very High Very High Very High
cINOD 4 99.28 Very High Very High Very High
imagery 4 98.88 Very High Very High Very High
antidepressant 4 97.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 17 100.00 Very High Very High Very High
Stress 7 100.00 Very High Very High Very High
Pain 3 100.00 Very High Very High Very High
Drug Induced Neurotoxicity 2 99.76 Very High Very High Very High
Disease 181 99.58 Very High Very High Very High
Chills 2 99.44 Very High Very High Very High
Poisoning 2 99.20 Very High Very High Very High
INFLAMMATION 2 99.08 Very High Very High Very High
Amyloid Plaque 9 98.72 Very High Very High Very High
Cancer 6 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Biochemical examination showed increases in total and free cholesterol levels in males given 600 mg/kg/day or more, an increased cholinesterase and decreased levels of triglyceride and cholesterol ester ratio in males given 1800 mg/kg/day.
Positive_regulation (increased) of cholinesterase
1) Confidence 0.66 Published 1992 Journal J Toxicol Sci Section Abstract Doc Link 1321257 Disease Relevance 0.59 Pain Relevance 0.09
BACKGROUND: Cholinesterase inhibitors which reach the central nervous system produce pain relief but are poorly tolerated because of gastrointestinal side effects.
Positive_regulation (tolerated) of Cholinesterase in central nervous system associated with pain and central nervous system
2) Confidence 0.50 Published 2007 Journal Anesthesiology Section Abstract Doc Link 17457135 Disease Relevance 0.25 Pain Relevance 0.28
The data suggest that some alterations in the brain functional state may outlast the CVP induced depression of cholinesterase activity.
Positive_regulation (induced) of cholinesterase in brain associated with depression
3) Confidence 0.47 Published 1990 Journal Pol J Occup Med Section Abstract Doc Link 2130875 Disease Relevance 0.18 Pain Relevance 0.13
Cholinesterase inhibitors increase secretion of APPs in rat brain cortex.
Positive_regulation (increase) of Cholinesterase in brain
4) Confidence 0.45 Published 1995 Journal Neuroreport Section Title Doc Link 7605915 Disease Relevance 0.16 Pain Relevance 0.07
Arginine administration decreases cerebral cortex acetylcholinesterase and serum butyrylcholinesterase probably by oxidative stress induction.
Positive_regulation (induction) of butyrylcholinesterase in cerebral cortex associated with stress and cerebral cortex
5) Confidence 0.43 Published 2004 Journal Neurochem. Res. Section Title Doc Link 15002734 Disease Relevance 0.25 Pain Relevance 0.16
Mesulam and Geula (1994) hypothesized a two-stage evolution of ß-amyloid plaques with a secondary development of local neurotoxicity due to the increase of butyrylcholinesterase at the plaque level.
Positive_regulation (increase) of butyrylcholinesterase in plaque associated with drug induced neurotoxicity and amyloid plaque
6) Confidence 0.43 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684084 Disease Relevance 0.55 Pain Relevance 0.13
Statistically significant elevations in cerebrospinal fluid/serum albumin ratio, acetylcholinesterase, butyrylcholinesterase activity, and total protein concentration were observed in lumbar cerebrospinal fluid of patients.
Positive_regulation (elevations) of butyrylcholinesterase in cerebrospinal fluid
7) Confidence 0.37 Published 2002 Journal Orthopade Section Abstract Doc Link 12149929 Disease Relevance 0.23 Pain Relevance 0.10
[Forensic-biochemical indices of serum amilase and cholinesterase activity in lethal poisoning with heroin].
Positive_regulation (indices) of cholinesterase associated with poisoning
8) Confidence 0.19 Published 2006 Journal Sud. Med. Ekspert. Section Title Doc Link 17191723 Disease Relevance 0.19 Pain Relevance 0.09
They deactivate cholinesterase, resulting in neurological dysfunction.
Positive_regulation (deactivate) of cholinesterase associated with anesthesia
9) Confidence 0.17 Published 2007 Journal Environ. Pollut. Section Abstract Doc Link 17218044 Disease Relevance 0.15 Pain Relevance 0.10
Increased acetylcholinesterase and butyrylcholinesterase activity point to pathophysiological impairment of neural tissues or meninges.
Positive_regulation (Increased) of butyrylcholinesterase in neural
10) Confidence 0.16 Published 2002 Journal Orthopade Section Abstract Doc Link 12149929 Disease Relevance 0.32 Pain Relevance 0.12
Although clinically significant elevations of aminotransferases and reductions of cholinesterase, and shaking chills were observed more often in group A than in group B (P<0.0001), these factors had little influence on the clinical outcome.
Positive_regulation (elevations) of cholinesterase associated with chills
11) Confidence 0.08 Published 2000 Journal J. Gastroenterol. Section Abstract Doc Link 10632537 Disease Relevance 0.96 Pain Relevance 0.08
Inactivation of cholinesterase induced by non-steroidal anti-inflammatory drugs with horseradish peroxidase: implication for Alzheimer's disease.
Positive_regulation (induced) of cholinesterase associated with inflammation, cinod and disease
12) Confidence 0.07 Published 2009 Journal Life Sci. Section Title Doc Link 19111561 Disease Relevance 0.20 Pain Relevance 0.37
In the multiple-dose study, the cholinesterase activity was gradually increased and reached above the normal range on day 8 in 3 of 6 subjects given Z-321 and gradually returned to the normal range after completion of dosing.
Positive_regulation (increased) of cholinesterase
13) Confidence 0.05 Published 1999 Journal J Clin Pharmacol Section Abstract Doc Link 10234593 Disease Relevance 0.35 Pain Relevance 0.14
It is not clear whether SSRIs enhance AD patient function by enhancing cholinesterase inhibitor effects or vice versa.
Spec (whether) Positive_regulation (enhancing) of cholinesterase associated with disease and ssri
14) Confidence 0.05 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656299 Disease Relevance 0.72 Pain Relevance 0.53
The elevation of plasma cholinesterase activity was considered to be an action of Z-321, but this remains to be verified.
Positive_regulation (elevation) of cholinesterase in plasma
15) Confidence 0.04 Published 1999 Journal J Clin Pharmacol Section Abstract Doc Link 10234593 Disease Relevance 0.42 Pain Relevance 0.17
Histochemically, the axon terminals are reactive for cytochrome oxidase activity, and the terminal Schwann cells have both non-specific cholinesterase and acid phosphatase activity.
Positive_regulation (reactive) of cholinesterase in terminal Schwann cells
16) Confidence 0.03 Published 1999 Journal Crit. Rev. Oral Biol. Med. Section Abstract Doc Link 10759411 Disease Relevance 0.05 Pain Relevance 0.13
As histochemical marker enzymes for the periodontal Ruffini endings, the axon terminals and terminal Schwann cells are reactive for cytochrome oxidase activity and both acid phosphatase activity and non-specific cholinesterase activity, respectively.
Positive_regulation (reactive) of cholinesterase in terminal Schwann cells
17) Confidence 0.03 Published 1998 Journal Kaibogaku Zasshi Section Abstract Doc Link 9617078 Disease Relevance 0 Pain Relevance 0.07
The best evidence currently exists for cholinesterase inhibitors and serotonin-specific reuptake inhibitor antidepressants.
Positive_regulation (exists) of cholinesterase associated with antidepressant and serotonin
18) Confidence 0.02 Published 2008 Journal Drugs Aging Section Abstract Doc Link 18447403 Disease Relevance 0.51 Pain Relevance 0.34

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