INT6066

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Context Info
Confidence 0.43
First Reported 1987
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 1.36
Pain Relevance 16.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)
Anatomy Link Frequency
neurons 2
tail 2
caudate putamen 2
brainstem nucleus 2
hippocampus 2
Oprd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 49 100.00 Very High Very High Very High
Opioid 34 100.00 Very High Very High Very High
Morphine 31 100.00 Very High Very High Very High
Enkephalin 23 100.00 Very High Very High Very High
Delta opioid receptors 20 100.00 Very High Very High Very High
Kappa opioid receptor 7 100.00 Very High Very High Very High
medulla 4 100.00 Very High Very High Very High
dopamine receptor 4 100.00 Very High Very High Very High
Analgesic 3 100.00 Very High Very High Very High
Endogenous opioid 2 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diarrhoea 1 97.12 Very High Very High Very High
Tremor 1 95.96 Very High Very High Very High
Opiate Addiction 5 95.88 Very High Very High Very High
Urological Neuroanatomy 1 94.44 High High
Increased Venous Pressure Under Development 2 94.28 High High
Hypothermia 1 92.28 High High
Injury 1 86.68 High High
Aging 1 75.16 Quite High
Headache 3 71.04 Quite High
Menstral Migraine 1 62.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the enhanced inhibitory effect of opioid receptor activation in the presence of yohimbine is not found for all opioid receptors.
Negative_regulation (effect) of Positive_regulation (activation) of opioid receptor associated with opioid receptor
1) Confidence 0.43 Published 1991 Journal Life Sci. Section Abstract Doc Link 1671792 Disease Relevance 0 Pain Relevance 0.78
Inhibition of enkephalin metabolism and activation of mu- or delta-opioid receptors elicit opposite effects on reward and motility in the ventral mesencephalon.
Negative_regulation (Inhibition) of Positive_regulation (activation) of delta-opioid in ventral associated with delta opioid receptors and enkephalin
2) Confidence 0.37 Published 1992 Journal Neuropharmacology Section Title Doc Link 1321359 Disease Relevance 0 Pain Relevance 1.17
Previous investigations have shown that the activation of delta-opioid receptors depresses the release of acetylcholine (ACh) in the rat caudate putamen.
Negative_regulation (depresses) of Positive_regulation (activation) of delta-opioid in caudate putamen associated with delta opioid receptors
3) Confidence 0.36 Published 1991 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 1647849 Disease Relevance 0 Pain Relevance 0.23
From a behavioral perspective, activation of delta-opioid receptors in the brainstem nucleus, lacking an effect in opioid naive rats, became analgesic in morphine-tolerant rats and significantly reduced morphine tolerance.
Negative_regulation (reduced) of Positive_regulation (activation) of delta-opioid in brainstem nucleus associated with medulla, analgesic, tolerance, delta opioid receptors, opioid and morphine
4) Confidence 0.31 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16399848 Disease Relevance 0.18 Pain Relevance 2.30
Namely, the activation of kappa opioid receptor led to the decrease in this stimulation, but activation of mu opioid receptor was without any effect.
Negative_regulation (decrease) of Positive_regulation (activation) of opioid receptor associated with mu opioid receptor and kappa opioid receptor
5) Confidence 0.30 Published 1995 Journal Pol J Pharmacol Section Abstract Doc Link 8688884 Disease Relevance 0 Pain Relevance 0.84
Upon simultaneous activation of D-1 dopamine receptors and delta-opioid receptors the (mu-receptor-mediated) inhibitory effect of morphine was abolished, while it was not changed following simultaneous activation of D-1 and (inhibitory) D-2 dopamine receptors.
Negative_regulation (abolished) of Positive_regulation (activation) of delta-opioid associated with dopamine receptor, delta opioid receptors and morphine
6) Confidence 0.29 Published 1987 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 3035383 Disease Relevance 0 Pain Relevance 1.31
In contrast, a highly specific decrease in kappa(2)-, but increase in kappa(1)-, opioid receptor binding was noted in the hippocampus of rats in both butorphanol-dependent and-withdrawal groups.
Negative_regulation (decrease) of Positive_regulation (increase) of opioid receptor in hippocampus associated with butorphanol, hippocampus, opioid receptor and withdrawal
7) Confidence 0.25 Published 2002 Journal Brain Res. Section Abstract Doc Link 12470863 Disease Relevance 0.09 Pain Relevance 1.86
Other interactions between progesterone and neurotransmitter systems include stimulation of dopamine release in striatal tissue, stimulation of GnRH release from hypothalamic neurons and inhibition of opioid receptor binding and activation.
Negative_regulation (inhibition) of Positive_regulation (activation) of opioid receptor in neurons associated with dopamine, neurotransmitter and opioid receptor
8) Confidence 0.25 Published 2003 Journal Maturitas Section Abstract Doc Link 14670648 Disease Relevance 0.20 Pain Relevance 0.49
These data suggest that an increase in opioid receptor occupancy by endogenous opioid peptides, protected from biotransformation specially by mixed inhibitors reduced the severity of the morphine abstinence symptoms in rats.
Negative_regulation (reduced) of Positive_regulation (increase) of opioid receptor associated with endogenous opioid, opioid receptor and morphine
9) Confidence 0.21 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2776828 Disease Relevance 0.53 Pain Relevance 0.72
So, in light of the previous findings and the present experimental data it can be said that: (1) supersensitivity to opioids may be a downregulation of NMDA as well as an upregulation of the opioid receptor; (2) either upregulation or downregulation of NMDA receptors may facilitate subsequent development of opioid dependence; (3) tolerance to opioid may necessitate both upregulation of NMDA receptors and downregulation of opioid receptors; and (4) beneficial effects of opioid antagonists in the treatment of opiate dependence and CNS injuries may be strongly related to the down regulation of NMDA receptors.
Negative_regulation (downregulation) of Positive_regulation (upregulation) of opioid receptor associated with nmda receptor, opioid receptor, addiction, antagonist, tolerance, injury, opiate and opioid
10) Confidence 0.14 Published 1999 Journal Pharmacol. Res. Section Abstract Doc Link 10208762 Disease Relevance 0.27 Pain Relevance 1.43
In both CHO-micro cells and CHO-micro/IRAS cells, agmatine (0.01-10 microM) did not affect the desensitization of micro opioid receptor induced by [d-Ala(2), N-Me-Phe(4),Gly(5)-ol]-enkephalin (DAMGO) (10 microM) treatment for 30 min.
Negative_regulation (desensitization) of Positive_regulation (induced) of micro opioid receptor associated with enkephalin and opioid receptor
11) Confidence 0.12 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18845140 Disease Relevance 0 Pain Relevance 0.54
It is concluded that opioids reduce CAP peak amplitudes in a manner being independent of opioid-receptor activation and with an efficacy being much less than that of cocaine.
Negative_regulation (reduce) of Positive_regulation (activation) of opioid-receptor associated with opioid and cocaine
12) Confidence 0.11 Published 2008 Journal Life Sci. Section Abstract Doc Link 18593589 Disease Relevance 0 Pain Relevance 2.28
The EPSPs were reduced by mu- but not delta-opioid receptor activation.
Neg (not) Negative_regulation (reduced) of Neg (not) Positive_regulation (activation) of delta-opioid receptor associated with opioid receptor
13) Confidence 0.06 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 8126561 Disease Relevance 0 Pain Relevance 0.80
This suggests that prenatal morphine exposure disrupts LTP via disruption of opioid mechanisms involved in LTP maintenance or via disruption of opioid receptor activation during LTP induction, which can subsequently alter LTP maintenance.
Negative_regulation (disruption) of Positive_regulation (activation) of opioid receptor associated with opioid receptor, long-term potentiation, opioid and morphine
14) Confidence 0.01 Published 2008 Journal J. Neurophysiol. Section Abstract Doc Link 18199817 Disease Relevance 0.08 Pain Relevance 1.51
Sequestration of free G protein beta gamma dimers by transient transfection of cells with a beta gamma binding protein (residues 495-689 of the C terminal tail of G protein-coupled receptor kinase 2) reduced the ability of delta opioid receptor activation to elevate [Ca(2+)](i).
Negative_regulation (reduced) of Positive_regulation (activation) of opioid receptor in tail associated with opioid receptor
15) Confidence 0.01 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11259487 Disease Relevance 0 Pain Relevance 0.34

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