INT60667

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Context Info
Confidence 0.67
First Reported 1996
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 0.44
Pain Relevance 3.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (HTR2A) aging (HTR2A) plasma membrane (HTR2A)
response to stress (HTR2A) cytoplasm (HTR2A) signal transducer activity (HTR2A)
Anatomy Link Frequency
brain 3
beta cell 1
HTR2A (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 30 97.76 Very High Very High Very High
Serotonin 7 97.08 Very High Very High Very High
fifth nerve 1 90.36 High High
antagonist 7 88.72 High High
headache 3 88.24 High High
Migraine 7 87.88 High High
Sumatriptan 4 83.44 Quite High
Potency 2 71.16 Quite High
agonist 4 67.76 Quite High
Triptan 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Migraine Disorders 7 88.24 High High
Cluster Headache 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Constitutive mRNA for 5-HT2A receptors was present in control and transfected C6 glial/5-HT1D beta cells, whereas mRNA for 5-HT1D beta receptor sites was only present in the transfected C6 glial/5-HT1D beta cell line. 5-HT inhibited forskolin-stimulated cyclic AMP formation and promoted cell growth, in contrast to the absence of any measurable effect in pcDNA3 plasmid-transfected and nontransfected C6 glial cells.
Transcription (present) of 5-HT2A in beta cell
1) Confidence 0.67 Published 1996 Journal J. Neurochem. Section Abstract Doc Link 8522991 Disease Relevance 0 Pain Relevance 0.15
In the present study the cultures were found by RT-PCR to express mRNA for 5-HT2A and 5-HT2B receptors, but not for the 5-HT2C receptor, identifying the 5-HT2 receptor activated by fluoxetine as the 5-HT2B receptor, the most recently cloned 5-Ht2 receptor and a 5-HT receptor known to be more abundant in human, than in rodent, brain.
Transcription (express) of 5-HT2 in brain associated with fluoxetine
2) Confidence 0.67 Published 2002 Journal Neurochem. Res. Section Abstract Doc Link 11930908 Disease Relevance 0 Pain Relevance 0.78
In the present study the cultures were found by RT-PCR to express mRNA for 5-HT2A and 5-HT2B receptors, but not for the 5-HT2C receptor, identifying the 5-HT2 receptor activated by fluoxetine as the 5-HT2B receptor, the most recently cloned 5-Ht2 receptor and a 5-HT receptor known to be more abundant in human, than in rodent, brain.
Transcription (express) of 5-HT2 in brain associated with fluoxetine
3) Confidence 0.67 Published 2002 Journal Neurochem. Res. Section Abstract Doc Link 11930908 Disease Relevance 0 Pain Relevance 0.79
In the present study the cultures were found by RT-PCR to express mRNA for 5-HT2A and 5-HT2B receptors, but not for the 5-HT2C receptor, identifying the 5-HT2 receptor activated by fluoxetine as the 5-HT2B receptor, the most recently cloned 5-Ht2 receptor and a 5-HT receptor known to be more abundant in human, than in rodent, brain.
Transcription (express) of 5-HT2 in brain associated with fluoxetine
4) Confidence 0.67 Published 2002 Journal Neurochem. Res. Section Abstract Doc Link 11930908 Disease Relevance 0 Pain Relevance 0.77
All tissues expressed 5-HT1Dbeta, 5-HT2A, 5-HT2B, 5-HT4 and 5-HT7 mRNAs.
Transcription (expressed) of 5-HT2A
5) Confidence 0.52 Published 1996 Journal Eur. J. Neurosci. Section Abstract Doc Link 8743744 Disease Relevance 0.44 Pain Relevance 0.94
Expression of 5-HT1F and 5-HT2A receptor mRNAs was never detected in any of the microvascular cell cultures.
Transcription (Expression) of 5-HT2A
6) Confidence 0.52 Published 1999 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 10458598 Disease Relevance 0 Pain Relevance 0.14
Expression of 5-HT1F and 5-HT2A receptor mRNAs was never detected in any of the microvascular cell cultures.
Transcription (detected) of 5-HT2A
7) Confidence 0.52 Published 1999 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 10458598 Disease Relevance 0 Pain Relevance 0.15

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