INT6067

Context Info Confidence 0.69 First Reported 1984 Last Reported 2010 Negated 1 Speculated 3 Reported most in Abstract Documents 37 Total Number 40 Disease Relevance 6.56 Pain Relevance 36.58

plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)

Anatomy Link Frequency medulla 3 spinal cord 2 spike 2 brain 2 dorsal horn 2 Oprd1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat opioid receptor 182 100.00 Morphine 148 100.00 agonist 71 100.00 Opioid 62 100.00 Enkephalin 59 100.00 narcan 28 100.00 medulla 22 100.00 Spinal cord 16 100.00 Delta opioid receptors 15 100.00 adenocard 15 100.00

Disease Link Frequency Relevance Heat Nociception 23 100.00 Hyperalgesia 4 99.98 INFLAMMATION 16 99.64 Pheochromocytoma 6 99.48 Appetite Loss 4 99.44 Cv Unclassified Under Development 3 99.12 Injury 11 99.08 Pain 72 99.00 Parkinson's Disease 3 98.08 Disease 11 97.16

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Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

NGF treatment of PC12h cells also results in the induction of delta opioid receptor (DOR-1) mRNA.

Positive_regulation (results) of Positive_regulation (induction) of delta opioid receptor associated with nerve growth factor and opioid receptor

1) Confidence 0.69 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7562535 Disease Relevance 0.16 Pain Relevance 0.60

NGF treatment of PC12h cells also results in the induction of delta opioid receptor (DOR-1) mRNA.

Positive_regulation (results) of Positive_regulation (induction) of DOR-1 associated with nerve growth factor and opioid receptor

2) Confidence 0.49 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7562535 Disease Relevance 0.16 Pain Relevance 0.61

The results show that opioid receptor activation in the LPBN induces hypertonic sodium intake in satiated and normohydrated rats, an effect not due to general ingestive behavior facilitation.

Positive_regulation (induces) of Positive_regulation (activation) of opioid receptor in LPBN associated with opioid receptor

3) Confidence 0.49 Published 2008 Journal Neuroscience Section Abstract Doc Link 18602454 Disease Relevance 0 Pain Relevance 0.52

These results provide evidence that naltrex-one-induced upregulation of the opioid receptor complex might occur indirectly as a consequence of interactions at beta-funaltrexamine-insensitive opioid receptors and that morphine-induced upregulation (increased Bmax) of the opioid receptor complex is a relevant in vitro marker related to the development of tolerance and dependence.

Positive_regulation (naltrex-one-induced) of Positive_regulation (upregulation) of opioid receptor associated with addiction, tolerance, opioid receptor and morphine

4) Confidence 0.48 Published 1991 Journal Peptides Section Abstract Doc Link 1646998 Disease Relevance 0 Pain Relevance 1.49

These results provide evidence that naltrex-one-induced upregulation of the opioid receptor complex might occur indirectly as a consequence of interactions at beta-funaltrexamine-insensitive opioid receptors and that morphine-induced upregulation (increased Bmax) of the opioid receptor complex is a relevant in vitro marker related to the development of tolerance and dependence.

Positive_regulation (morphine-induced) of Positive_regulation (upregulation) of opioid receptor associated with addiction, tolerance, opioid receptor and morphine

5) Confidence 0.48 Published 1991 Journal Peptides Section Abstract Doc Link 1646998 Disease Relevance 0 Pain Relevance 1.36

These results provide evidence that naltrex-one-induced upregulation of the opioid receptor complex might occur indirectly as a consequence of interactions at beta-funaltrexamine-insensitive opioid receptors and that morphine-induced upregulation (increased Bmax) of the opioid receptor complex is a relevant in vitro marker related to the development of tolerance and dependence.

Positive_regulation (increased) of Positive_regulation (upregulation) of opioid receptor associated with addiction, tolerance, opioid receptor and morphine

6) Confidence 0.48 Published 1991 Journal Peptides Section Abstract Doc Link 1646998 Disease Relevance 0 Pain Relevance 1.35

Both peptides concentration dependently (1 nM-1 microM) inhibited the release of radiolabeled acetylcholine (ACh) from striatal slices (pD2 7.6-7.9), an effect exclusively mediated by delta-opioid receptor activation.

Positive_regulation (mediated) of Positive_regulation (activation) of delta-opioid receptor associated with opioid receptor

7) Confidence 0.48 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2575993 Disease Relevance 0 Pain Relevance 0.68

Therefore, the purpose of the present study was to test the hypothesis that ischemia- and morphine-induced cardioprotection are mediated via stimulation of the delta-opioid receptor in the rat heart.

Positive_regulation (mediated) of Positive_regulation (stimulation) of delta-opioid receptor in heart associated with ischemia, opioid receptor and morphine

8) Confidence 0.46 Published 1997 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 9281450 Disease Relevance 0.26 Pain Relevance 0.95

Although it is still unclear about the cellular and molecular mechanisms of morphine analgesia, evidence supported that morphine-induced opioid-receptor activation results in the enhancement of phosphorylation of mitogen-activated protein kinase (MAPK) in ACC, SI and locus ceruleus [38].

Positive_regulation (induced) of Positive_regulation (activation) of opioid-receptor associated with primary somatosensory cortex, locus ceruleus, anterior cingulate cortex, opioid, analgesia and morphine

9) Confidence 0.45 Published 2009 Journal Mol Pain Section Body Doc Link PMC2770513 Disease Relevance 0.86 Pain Relevance 2.45

On the contrary, activation of both mu- or delta-opioid receptors in the ventral tegmental area significantly increased self-stimulation and decreased spontaneous motor activity, supporting the view that different mechanisms underlie the behavioural effects, resulting from enhancement of endogenous enkephalins and from activation of specific opioid receptors in the ventral mesencephalon.

Positive_regulation (increased) of Positive_regulation (activation) of delta-opioid in mesencephalon associated with ventral tegmentum, opioid receptor, enkephalin and delta opioid receptors

10) Confidence 0.44 Published 1992 Journal Neuropharmacology Section Abstract Doc Link 1321359 Disease Relevance 0 Pain Relevance 0.96

The antihyperalgesic potency of the mu opioid receptor agonist [D-Ala(2),N-Me-Phe(4),Gly(5)-ol]enkephalin (DAMGO), determined for the inflamed hindpaw, was enhanced 4 d and 2 weeks after injury.

Positive_regulation (enhanced) of Spec (determined) Positive_regulation (potency) of opioid receptor associated with antihyperalgesic, injury, agonist, mu opioid receptor, enkephalin and potency

11) Confidence 0.43 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10648729 Disease Relevance 0.85 Pain Relevance 1.09

Furthermore, both DSTBULET and BUBU caused a strong inhibition (pD2 8.2-8.3) of D-1 dopamine receptor-stimulated cyclic AMP efflux from striatal slices, an effect known to be mediated by mu- and/or delta-opioid receptor activation.

Positive_regulation (mediated) of Positive_regulation (activation) of delta-opioid receptor associated with dopamine receptor and opioid receptor

12) Confidence 0.42 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2575993 Disease Relevance 0 Pain Relevance 0.82

The interactions between dopamine receptors and opioid receptors coupled to adenylate cyclase in rat neostriatum were investigated. cAMP efflux from neostriatal slices induced by simultaneous activation of (stimulatory) D-1 and (inhibitory) D-2 dopamine receptors with 30 microM dopamine was inhibited by the preferential delta-opioid receptor agonist [D-Ala2-D-Leu5] enkephalin (DADLE) and the mu-opioid receptor agonist morphine with an EC50 of 100 and 800 nM, respectively.

Positive_regulation (induced) of Positive_regulation (activation) of D-1 associated with dopamine, dopamine receptor, agonist, enkephalin, opioid receptor and morphine

13) Confidence 0.37 Published 1986 Journal J. Neurosci. Section Abstract Doc Link 3018189 Disease Relevance 0 Pain Relevance 0.94

Inflammation and hyperalgesia induce a dramatic up-regulation of opioid messenger RNA and peptide levels in nociceptive neurons of the spinal dorsal horn.

Positive_regulation (induce) of Positive_regulation (up-regulation) of opioid messenger RNA in dorsal horn associated with nociception, hyperalgesia, inflammation, spinal dorsal horn and opioid

14) Confidence 0.36 Published 1999 Journal Neuroscience Section Abstract Doc Link 10197770 Disease Relevance 0.97 Pain Relevance 0.85

This finding is contradictory to the generally held view that antagonist-induced opioid receptor up-regulation in brain increases asymptotically, leveling off after a relatively brief treatment period.

Positive_regulation (induced) of Positive_regulation (up-regulation) of opioid receptor in brain associated with antagonist and opioid receptor

15) Confidence 0.36 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2173747 Disease Relevance 0 Pain Relevance 0.32

These results clearly indicate that activation of the mu opioid receptor increases the number of spike-wave discharges, and that modulation of delta receptors is not effective.

Positive_regulation (increases) of Positive_regulation (activation) of opioid receptor in spike associated with mu opioid receptor

16) Confidence 0.35 Published 1994 Journal Neuropharmacology Section Abstract Doc Link 8035901 Disease Relevance 0.34 Pain Relevance 0.56

PERSPECTIVE: Although the role of adenosine release in the spinal cord for opioid receptor activation in subsequent analgesia from opioids is controversial in laboratory studies, these clinical data suggest that local opioid receptor stimulation in the spinal cord of humans does release adenosine.

Positive_regulation (role) of Positive_regulation (activation) of opioid receptor in spinal cord associated with adenocard, opioid receptor, opioid, analgesia and spinal cord

17) Confidence 0.34 Published 2004 Journal J Pain Section Abstract Doc Link 14975380 Disease Relevance 0 Pain Relevance 2.51

An alternative hypothesis is that opioid receptors remain operative following repeated opiate administration but that opioid receptor activation rapidly induces a prolonged increase in pain sensitivity which opposes the predominant opiate analgesic effect following repeated opiate administration.

Positive_regulation (induces) of Positive_regulation (activation) of opioid receptor associated with pain, analgesic, opiate and opioid receptor

18) Confidence 0.29 Published 1999 Journal Neuroscience Section Abstract Doc Link 10199599 Disease Relevance 0.37 Pain Relevance 1.54

Chronic fentanyl treatments induce the up-regulation of mu opioid receptor mRNA in rat pheochromocytoma cells.

Positive_regulation (induce) of Positive_regulation (induce) of opioid receptor associated with mu opioid receptor and pheochromocytoma

19) Confidence 0.21 Published 2000 Journal Brain Res. Section Title Doc Link 10719067 Disease Relevance 0.18 Pain Relevance 0.64

These results indicate that vasodilator responses to TAPP and endomorphin 2 are mediated by the activation of a naloxone-sensitive opioid receptor and the release of nitric oxide from the endothelium within the hindquarter vascular bed of the rat.

Positive_regulation (mediated) of Positive_regulation (activation) of opioid receptor in endothelium associated with narcan and opioid receptor

20) Confidence 0.21 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9612381 Disease Relevance 0.06 Pain Relevance 0.36

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