INT60672

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Context Info
Confidence 0.61
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.76
Pain Relevance 2.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CALCA) aging (CALCA) extracellular region (CALCA)
nucleus (CALCA) intracellular (CALCA) cell-cell signaling (CALCA)
Anatomy Link Frequency
endothelial cell 2
bowel 2
CALCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 37 100.00 Very High Very High Very High
substance P 27 100.00 Very High Very High Very High
Calcitonin gene-related peptide 19 100.00 Very High Very High Very High
calcitonin gene related peptide 16 100.00 Very High Very High Very High
Clonidine 9 100.00 Very High Very High Very High
burning pain 1 100.00 Very High Very High Very High
anesthesia 3 98.12 Very High Very High Very High
qutenza 6 87.72 High High
antagonist 19 80.72 Quite High
TRP channel 2 73.32 Quite High
Disease Link Frequency Relevance Heat
Esophageal Disease 22 100.00 Very High Very High Very High
Natriuresis 2 100.00 Very High Very High Very High
Neurogenic Inflammation 2 100.00 Very High Very High Very High
Disease 2 100.00 Very High Very High Very High
Inflammatory Bowel Disease 1 100.00 Very High Very High Very High
Pain 1 100.00 Very High Very High Very High
INFLAMMATION 48 99.64 Very High Very High Very High
Gastroesophageal Reflux Disease 12 92.20 High High
Pressure And Volume Under Development 1 90.52 High High
Colitis 1 55.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of clonidine on endothelial cell-derived CGRP synthesis and secretion was attenuated in the presence of yohimbine.
Regulation (effect) of Gene_expression (synthesis) of CGRP in endothelial cell associated with calcitonin gene-related peptide and clonidine
1) Confidence 0.61 Published 2009 Journal Peptides Section Abstract Doc Link 19520131 Disease Relevance 0 Pain Relevance 1.21
[Calcitonin gene-related peptide and human atrial natriuretic hormone levels in response to cardiac operation under high dose fentanyl anesthesia].
Regulation (response) of Gene_expression (levels) of gene-related peptide associated with natriuresis, anesthesia and calcitonin gene-related peptide
2) Confidence 0.39 Published 1995 Journal Masui Section Title Doc Link 8523650 Disease Relevance 0.28 Pain Relevance 0.65
TRPV1 is now believed to function as a molecular integrator of noxious stimuli, including acids, heat, pollutants with negative electric charge and endogenous pro-inflammatory substances.16 Up-regulated TRPV1 expression has been demonstrated in disease states of the gastrointestinal tract such as inflammatory bowel disease,17 irritable bowel syndrome18 and, more recently, esophagitis.19,20 TRPV1 activation in primary afferent neurons evokes the sensation of burning pain and induces neurogenic inflammation by the release of substance P (SP) and calcitonin-gene-related peptide (CGRP).17,21

2.

Regulation (regulated) of Gene_expression (expression) of CGRP in bowel associated with calcitonin gene related peptide, esophageal disease, inflammation, neurogenic inflammation, disease, substance p and burning pain
3) Confidence 0.18 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 1.48 Pain Relevance 0.99

General Comments

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