INT60685

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Context Info
Confidence 0.53
First Reported 1995
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 21
Total Number 24
Disease Relevance 15.86
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Epo) aging (Epo) extracellular region (Epo)
Anatomy Link Frequency
megakaryocytes 6
bone marrow 6
Epo (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 185 98.88 Very High Very High Very High
Hippocampus 17 94.16 High High
bDMF 39 90.56 High High
cytokine 90 90.00 High High
headache 2 85.96 High High
positron emission tomography 7 77.20 Quite High
COX-2 inhibitor 1 70.72 Quite High
withdrawal 1 69.28 Quite High
aspirin 5 65.12 Quite High
Angina 2 57.76 Quite High
Disease Link Frequency Relevance Heat
Erythremia 9 100.00 Very High Very High Very High
Erythrocytosis 9 99.82 Very High Very High Very High
Anaemia 84 99.80 Very High Very High Very High
Hypoxia 238 99.56 Very High Very High Very High
Liver Cell Adenoma 1 99.08 Very High Very High Very High
Cv Unclassified Under Development 99 98.88 Very High Very High Very High
Chronic Renal Failure 3 98.88 Very High Very High Very High
Disease 29 98.80 Very High Very High Very High
Congenital Anomalies 4 98.68 Very High Very High Very High
Chronic Disease 4 97.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several solutions to the processes of anemia, such as blunted erythropoietin production and erythropoietin response and abnormalities in iron metabolism have been developed.
Positive_regulation (blunted) of Gene_expression (production) of erythropoietin associated with anaemia and congenital anomalies
1) Confidence 0.53 Published 2004 Journal Crit Care Clin Section Abstract Doc Link 15135458 Disease Relevance 1.00 Pain Relevance 0
PCNA was increased in the EPO and GM-CSF+ EPO groups, while there was no increase in the GM-CSF group.


Positive_regulation (increased) of Gene_expression (groups) of EPO
2) Confidence 0.50 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2917416 Disease Relevance 0 Pain Relevance 0
[Erythropoietin and transfusions in patients with anemia of chronic renal failure origin : an update view].
Positive_regulation (transfusions) of Gene_expression (transfusions) of Erythropoietin associated with chronic renal failure and anaemia
3) Confidence 0.50 Published 1995 Journal Rev Med Chil Section Title Doc Link 8525189 Disease Relevance 0.45 Pain Relevance 0.06
Immunohistochemistry demonstrated erythropoietin expression in the adenomatous cells.
Positive_regulation (demonstrated) of Gene_expression (expression) of erythropoietin
4) Confidence 0.50 Published 2009 Journal Acta Haematol. Section Abstract Doc Link 19339771 Disease Relevance 0.97 Pain Relevance 0.09
Future research can focus on the effect of these factors after hepatectomy when hepatic parenchymal disease coexists, as well as on the role of autologous transfusion inducing endogenous EPO production.
Positive_regulation (inducing) of Gene_expression (production) of EPO associated with disease
5) Confidence 0.46 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2917416 Disease Relevance 0.26 Pain Relevance 0
The anti-apoptotic protein Bcl-2 was significantly upregulated in EPO+G-CSF, EPO, and G-CSF groups, compared with control group (Fig. 4J), and the EPO+G-CSF combination induced significantly greater expression of Bcl-2 than EPO or G-CSF alone 24 hr after ischemia (Fig. 4J).
Positive_regulation (induced) of Gene_expression (expression) of EPO associated with ischemia and apoptosis
6) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852409 Disease Relevance 0.49 Pain Relevance 0.21
In contrast, G-CSF or EPO+G-CSF injection did not stimulate the additive upregulation of serum EPO in the Tg-HIF-1?
Neg (not) Positive_regulation (stimulate) of Gene_expression (injection) of EPO
7) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852409 Disease Relevance 0.40 Pain Relevance 0.16
Intraperitoneal injection of r-Hu-EPO following I-R
Positive_regulation (following) of Gene_expression (injection) of r-Hu-EPO
8) Confidence 0.43 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998786 Disease Relevance 0.20 Pain Relevance 0.08
PCNA was increased in the EPO and GM-CSF+ EPO groups, while there was no increase in the GM-CSF group.


Positive_regulation (increased) of Gene_expression (groups) of EPO
9) Confidence 0.43 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2917416 Disease Relevance 0 Pain Relevance 0
The expression of VEGF, Flk-1, and EPO were significantly upregulated following hypoxia.
Positive_regulation (upregulated) of Gene_expression (expression) of EPO associated with hypoxia
10) Confidence 0.42 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 0.88 Pain Relevance 0
Next, to examine increased EPO protein expression from HIF-1?
Positive_regulation (increased) of Gene_expression (expression) of EPO
11) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852409 Disease Relevance 0.15 Pain Relevance 0.10
and of EPO protein expression increased following G-CSF treatment (Fig. 1B–C).
Positive_regulation (increased) of Gene_expression (expression) of EPO
12) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852409 Disease Relevance 0.13 Pain Relevance 0.04
, which then binds to the EPO promoter and enhances EPO expression.
Positive_regulation (enhances) of Gene_expression (expression) of EPO
13) Confidence 0.41 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2852409 Disease Relevance 0.35 Pain Relevance 0.13
to upregulate EPO expression under normoxic conditions.
Positive_regulation (upregulate) of Gene_expression (expression) of EPO
14) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852409 Disease Relevance 0.37 Pain Relevance 0.08
bound to the HRE of the EPO promoter and turned on the expression of EPO.
Positive_regulation (turned) of Gene_expression (expression) of EPO
15) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852409 Disease Relevance 0.24 Pain Relevance 0.03
This and other studies of exogenous erythropoietin therapy in critically ill patients clearly demonstrate that the bone marrow in many of these patients will respond to the administration of erythropoietin despite their illness, suggesting a blunted production of erythropoietin rather than a blunted response to erythropoietin.
Spec (suggesting) Positive_regulation (suggesting) of Gene_expression (production) of erythropoietin in bone marrow associated with critical illness
16) Confidence 0.38 Published 2004 Journal Crit Care Clin Section Abstract Doc Link 15135458 Disease Relevance 1.20 Pain Relevance 0
This and other studies of exogenous erythropoietin therapy in critically ill patients clearly demonstrate that the bone marrow in many of these patients will respond to the administration of erythropoietin despite their illness, suggesting a blunted production of erythropoietin rather than a blunted response to erythropoietin.
Positive_regulation (response) of Gene_expression (production) of erythropoietin in bone marrow associated with critical illness
17) Confidence 0.38 Published 2004 Journal Crit Care Clin Section Abstract Doc Link 15135458 Disease Relevance 1.15 Pain Relevance 0
This and other studies of exogenous erythropoietin therapy in critically ill patients clearly demonstrate that the bone marrow in many of these patients will respond to the administration of erythropoietin despite their illness, suggesting a blunted production of erythropoietin rather than a blunted response to erythropoietin.
Positive_regulation (blunted) of Gene_expression (production) of erythropoietin in bone marrow associated with critical illness
18) Confidence 0.38 Published 2004 Journal Crit Care Clin Section Abstract Doc Link 15135458 Disease Relevance 1.14 Pain Relevance 0
Some results were able to correlate exercise-mediated EPC increase with increased levels of EPO in trained subjects (Steiner et al 2005).
Positive_regulation (increased) of Gene_expression (levels) of EPO
19) Confidence 0.23 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721378 Disease Relevance 0.28 Pain Relevance 0.07
Polycythemia vera is distinguished from reactive erythrocytosis through erythropoietin independent growth of erythroid progenitors in vitro, suppressed levels of endogenous erythropoietin, possible overexpression of PRV-1 (polycythemia rubra vera-1), decreased c-Mpl expression on megakaryocytes, as well as overexpression of bcl-xL, and potentially aberrant activity of the Jak-Stat pathway.
Spec (possible) Positive_regulation (overexpression) of Spec (possible) Gene_expression (overexpression) of erythropoietin in megakaryocytes associated with erythremia and erythrocytosis
20) Confidence 0.05 Published 2002 Journal Int. J. Hematol. Section Abstract Doc Link 12430925 Disease Relevance 1.66 Pain Relevance 0.03

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