INT60687

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Context Info
Confidence 0.20
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.20
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

COS (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 3 98.80 Very High Very High Very High
Morphine 8 98.60 Very High Very High Very High
opiate 2 88.04 High High
Analgesic 2 86.80 High High
mu opioid receptor 1 83.52 Quite High
Opioid 1 75.00 Quite High
narcan 1 67.60 Quite High
Enkephalin 1 25.00 Low Low
Bile 1 21.20 Low Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 9 78.80 Quite High
Unconsciousness 1 47.28 Quite Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Myocardial Infarction 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Coronary Artery Disease 1 5.00 Very Low Very Low Very Low
Alcohol Intoxication 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite the lack of scientific grounds, this theory had great success, above all in the aristocratic and high-bourgeois classes of Paris as well as widely spread and followed, as its quotation in Mozart’s opera Così fan tutte.11
Gene_expression (tutte.11) of Cos
1) Confidence 0.20 Published 2010 Journal Journal of multidisciplinary healthcare Section Body Doc Link PMC3004608 Disease Relevance 0.20 Pain Relevance 0
To determine if these sequence differences produced significant changes in ligand-selectivity profiles, we assessed these profiles in expressing COS and CHO cell lines using the agonist ligand [125I]IOXY-AGO (6 beta-[125Iodo]-3,14-dihydroxy-17-methyl-4,5 alpha- epoxymorphinan).
Gene_expression (expressing) of COS associated with agonist
2) Confidence 0.10 Published 1995 Journal Synapse Section Abstract Doc Link 8525463 Disease Relevance 0 Pain Relevance 0.55
Addition of CYP3A4 to untreated COS microsomes expressing UGT2B7 had no or minor effects on morphine glucuronidation.
Neg (no) Gene_expression (expressing) of COS associated with morphine
3) Confidence 0.03 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15611481 Disease Relevance 0 Pain Relevance 0.54

General Comments

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