INT60691

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Context Info
Confidence 0.78
First Reported 1995
Last Reported 2011
Negated 6
Speculated 4
Reported most in Body
Documents 331
Total Number 335
Disease Relevance 208.03
Pain Relevance 75.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il12a) extracellular region (Il12a) cytoplasm (Il12a)
Anatomy Link Frequency
macrophages 40
dendritic cells 16
T cells 12
monocytes 11
CD86 6
Il12a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 7070 100.00 Very High Very High Very High
Inflammation 4524 100.00 Very High Very High Very High
rheumatoid arthritis 886 100.00 Very High Very High Very High
chemokine 739 100.00 Very High Very High Very High
agonist 1178 99.92 Very High Very High Very High
Opioid 15 99.84 Very High Very High Very High
antagonist 402 99.80 Very High Very High Very High
Morphine 91 99.80 Very High Very High Very High
Central nervous system 939 99.72 Very High Very High Very High
Multiple sclerosis 696 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 4980 100.00 Very High Very High Very High
Cancer 3571 100.00 Very High Very High Very High
Rheumatoid Arthritis 966 100.00 Very High Very High Very High
Necrosis 428 100.00 Very High Very High Very High
Adhesions 262 100.00 Very High Very High Very High
Infection 9330 99.98 Very High Very High Very High
Cytomegalovirus Infection 249 99.96 Very High Very High Very High
Mycobacterial Infection 2768 99.92 Very High Very High Very High
Autoimmune Disease 426 99.92 Very High Very High Very High
Cold Sores 6651 99.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since we originally planned to administer recombinant murine IL-12 expressed in tomato fruits (tIL-12) without purification, and considering that when free IL-12 beta chain is found in excess, it has the capacity to form homodimers that function as specific IL-12 antagonists, we decided to express a single-chain IL-12 molecule encoded by only one gene, ensuring this way that there would be equivalent amounts of both IL-12 chains [10].
Gene_expression (expressed) of IL-12 associated with antagonist
1) Confidence 0.78 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2888828 Disease Relevance 0.16 Pain Relevance 0.13
AGO developed the transgenic tomato line expressing mouse IL-12, helped in conceiving the experiment and drafted the manuscript.
Gene_expression (expressing) of IL-12 associated with targeted disruption
2) Confidence 0.78 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2888828 Disease Relevance 0.19 Pain Relevance 0
Here we describe the in vivo activity of a single-chain IL-12 expressed in an edible crop, the tomato.
Gene_expression (expressed) of IL-12 in crop
3) Confidence 0.78 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2888828 Disease Relevance 0.15 Pain Relevance 0.06
CSH prepared extracts from transgenic tomato line expressing mouse IL-12, carried out most of the experimental work and helped in manuscript drafting.
Gene_expression (expressing) of IL-12 associated with targeted disruption
4) Confidence 0.78 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2888828 Disease Relevance 0.19 Pain Relevance 0.05
However, a mild toxicity was observed in mice treated with plant-expressed IL-12 as well as recombinant IL-12, according to a slight weight loss in both treatments (data not shown).
Gene_expression (expressed) of IL-12 associated with toxicity and weight loss
5) Confidence 0.78 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2888828 Disease Relevance 0.53 Pain Relevance 0.03
This opens the possibility of using crude extracts prepared from tomatoes expressing IL-12 for certain immunotherapies where the induction of a Th1 response is necessary.
Gene_expression (expressing) of IL-12
6) Confidence 0.78 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2888828 Disease Relevance 0.46 Pain Relevance 0.13
Effects of in vitro and in vivo opioids on the production of IL-12 and IL-10 by murine macrophages.
Gene_expression (production) of IL-12 in macrophages associated with pain and opioid
7) Confidence 0.73 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Title Doc Link 12794053 Disease Relevance 0 Pain Relevance 1.13
We evaluated the ability of the specific micro opioid receptor agonist DAMGO, the kappa-specific agonist U-50488 in vitro, and exogenous opioid morphine administered in vivo both acutely and chronically to modulate IL-12 and IL-10 production by murine peritoneal macrophages.
Gene_expression (production) of IL-12 in peritoneal macrophages associated with agonist, opioid receptor, opioid and morphine
8) Confidence 0.73 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12794053 Disease Relevance 0 Pain Relevance 0.65
Damgo and U-50488 at the concentrations of 10(-6) and 10(-8) M decreased the production of IL-12 without affecting IL-10.
Gene_expression (production) of IL-12
9) Confidence 0.73 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12794053 Disease Relevance 0 Pain Relevance 0.72
In this study, we investigated the capacity of in vivo acute and chronic morphine treatment to modulate interleukin (IL)-10 and IL-12 production by LPS and interferon-gamma-stimulated resident and thioglycollate-elicited murine peritoneal macrophages and the development of tolerance to these effects.
Gene_expression (production) of IL-12 in peritoneal macrophages associated with tolerance and morphine
10) Confidence 0.73 Published 2002 Journal J. Leukoc. Biol. Section Abstract Doc Link 12101261 Disease Relevance 0 Pain Relevance 0.62
Stimulation of interleukin-12 production in mouse macrophages via activation of p38 mitogen-activated protein kinase by alpha2-adrenoceptor agonists.
Gene_expression (production) of interleukin-12 in macrophages associated with agonist
11) Confidence 0.71 Published 2003 Journal Eur. J. Pharmacol. Section Title Doc Link 12706479 Disease Relevance 0 Pain Relevance 0.41
Interleukin-12 is a cytokine primarily produced by monocytes and macrophages.
Gene_expression (produced) of Interleukin-12 in macrophages associated with cytokine
12) Confidence 0.71 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12706479 Disease Relevance 0 Pain Relevance 0.27
Inhibitors of p38 MAPK prevented the stimulatory effects of alpha(2)-adrenoceptor agonists on IL-12 production.
Gene_expression (production) of IL-12 associated with agonist
13) Confidence 0.71 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12706479 Disease Relevance 0 Pain Relevance 0.56
This study was designed to determine if alpha(2)-adrenoceptor agonists are involved in the induction of interleukin-12 production by macrophages. alpha(2)-adrenoceptor agonists such as clonidine, guanfacine, and oxymetazoline significantly induced interleukin-12 secretion and interleukin-12 mRNA expression by macrophages in a concentration-dependent manner.
Gene_expression (production) of interleukin-12 in macrophages associated with agonist and clonidine
14) Confidence 0.71 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12706479 Disease Relevance 0 Pain Relevance 0.37
Morphine enhances interleukin-12 and the production of other pro-inflammatory cytokines in mouse peritoneal macrophages.
Gene_expression (production) of interleukin-12 in peritoneal macrophages associated with inflammation, cytokine and morphine
15) Confidence 0.67 Published 2000 Journal J. Leukoc. Biol. Section Title Doc Link 11073113 Disease Relevance 0.23 Pain Relevance 0.83
It is important to mention that the results presented here are from a single dose of 100 ng IL-12; nevertheless, we first tested a dose-response relationship between IL-12 administration and IFN-?
Gene_expression (administration) of IL-12
16) Confidence 0.67 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2888828 Disease Relevance 0.50 Pain Relevance 0.16
Since we originally planned to administer recombinant murine IL-12 expressed in tomato fruits (tIL-12) without purification, and considering that when free IL-12 beta chain is found in excess, it has the capacity to form homodimers that function as specific IL-12 antagonists, we decided to express a single-chain IL-12 molecule encoded by only one gene, ensuring this way that there would be equivalent amounts of both IL-12 chains [10].
Gene_expression (expressed) of tIL-12 associated with antagonist
17) Confidence 0.67 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2888828 Disease Relevance 0.17 Pain Relevance 0.13
levels increased significantly at 4 and 8 h in mice treated with IL-12; tIL-12 and rIL-12 induced INF-?
Gene_expression (treated) of IL-12
18) Confidence 0.67 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2888828 Disease Relevance 0.25 Pain Relevance 0
The inability of PTU to reduce CD1a expression in biopsy samples of patients with psoriasis suggests that the mechanism of action of this drug is psoriasis is not due to any effect on skin antigen-presenting cells or production of IL-12, a motive cytokine that is responsible for initiation and maintenance of the cytokine stimulatory cascade that leads to formation of the psoriatic plaque [16].
Gene_expression (production) of IL-12 in skin associated with psoriasis and cytokine
19) Confidence 0.67 Published 2003 Journal BMC Dermatol Section Body Doc Link PMC169161 Disease Relevance 0.52 Pain Relevance 0.23
Additional studies are being performed which address whether PTU treatment of patients with plaque psoriasis leads to reduced in situ IL-12 expression, alters production of the IL-35 or IL-40 components of the IL-70 heterodimer, as well as exerts an effect by enhancing apoptosis in the proliferated keratinocytes that make up the psoriatic plaque which would result in clinical improvement.


Gene_expression (expression) of IL-12 in keratinocytes associated with psoriasis and apoptosis
20) Confidence 0.67 Published 2003 Journal BMC Dermatol Section Body Doc Link PMC169161 Disease Relevance 0.53 Pain Relevance 0.21

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