INT60692

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Context Info
Confidence 0.10
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 8.47
Pain Relevance 6.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pglyrp1) extracellular region (Pglyrp1) cytoplasm (Pglyrp1)
Anatomy Link Frequency
bladder 3
skin 3
urinary bladder 1
liver 1
blood 1
Pglyrp1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 531 100.00 Very High Very High Very High
Inflammation 403 100.00 Very High Very High Very High
chemokine 122 99.90 Very High Very High Very High
cva 42 97.04 Very High Very High Very High
Inflammatory stimuli 33 96.96 Very High Very High Very High
Pain 46 96.60 Very High Very High Very High
Chronic pancreatitis 3 96.48 Very High Very High Very High
tolerance 2 95.32 Very High Very High Very High
ischemia 101 94.80 High High
Inflammatory response 37 93.88 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 478 100.00 Very High Very High Very High
Targeted Disruption 97 98.68 Very High Very High Very High
Nervous System Injury 9 98.56 Very High Very High Very High
Cancer 51 97.64 Very High Very High Very High
Necrosis 32 97.40 Very High Very High Very High
Cv General 3 Under Development 26 97.04 Very High Very High Very High
Pressure And Volume Under Development 67 96.64 Very High Very High Very High
Pain 43 96.60 Very High Very High Very High
Pancreatitis 4 96.48 Very High Very High Very High
Cv Unclassified Under Development 101 94.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The calpain inhibitor MDL-28710 blocks the early local pro-inflammatory cytokine gene expression in mice after chronic constriction nerve injury (CCI).
Gene_expression (expression) of cytokine gene in nerve associated with nervous system injury, inflammation and cytokine
1) Confidence 0.10 Published 2010 Journal Molecules Section Abstract Doc Link 20657463 Disease Relevance 0.67 Pain Relevance 0.38
At 24 hr, a massive neutrophil recruitment and an induced expression of a wide spectrum of murine cytokine mRNA (i.e., interleukin [IL]-1 beta, IL-4, IL-6, IL-10, IL-12, tumor necrosis factor [TNF]-alpha and interferon [IFN]-gamma) occurred in the huPBL-SCID mouse peritoneal cavity.
Gene_expression (expression) of cytokine mRNA in peritoneal cavity associated with necrosis, cancer, severe combined immunodeficiency and cytokine
2) Confidence 0.03 Published 1995 Journal Transplantation Section Abstract Doc Link 8525526 Disease Relevance 0.68 Pain Relevance 0.13
Cytokine gene expression in plantar skin is lower in NOS-KO mice after CFA compared to WT mice
Gene_expression (expression) of Cytokine gene in skin associated with targeted disruption and cytokine
3) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2838835 Disease Relevance 0.39 Pain Relevance 0.09
CFA increases both NOS and cytokine gene expression in plantar skin
Gene_expression (expression) of cytokine gene in skin associated with cytokine
4) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2838835 Disease Relevance 0.99 Pain Relevance 1.01
Pretreatment with 7-NINA, AG, L-NIO, or L-NAME at a dose of 50 mg/kg did not significantly alter cytokine gene expression in plantar skin of control mice (data not shown).
Gene_expression (expression) of cytokine gene in skin associated with cytokine
5) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2838835 Disease Relevance 0.23 Pain Relevance 0.23
Next, we used CHIP/Q-PCR to investigate whether acute BCG (24 hours after a single instillation) and chronic BCG (7 days after four weekly instillations) would also alter cytokine gene expression in the whole mouse bladder.
Gene_expression (expression) of cytokine gene in bladder associated with cytokine
6) Confidence 0.02 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.28 Pain Relevance 0.61
No appreciable levels of cytokine mRNA expression were observed in liver tissues of the matching sham-operated mice.
Gene_expression (expression) of cytokine mRNA in liver associated with cytokine
7) Confidence 0.01 Published 2006 Journal BMC Clin Pathol Section Body Doc Link PMC1382240 Disease Relevance 0.16 Pain Relevance 0.54
To determine whether intravesical BCG treatment would alter bladder cytokine gene expression, we used chromatin immunoprecipitation combined with Q-PCR.
Gene_expression (expression) of cytokine gene in bladder associated with cytokine
8) Confidence 0.01 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.20 Pain Relevance 0.28
In addition, chromatin immune precipitation combined with real-time polymerase chain reaction assay (CHIP/Q-PCR) was used to test whether intravesical BCG would alter bladder cytokine gene expression.


Gene_expression (expression) of cytokine gene in bladder associated with cytokine
9) Confidence 0.01 Published 2007 Journal BMC Immunol Section Abstract Doc Link PMC1891101 Disease Relevance 0.67 Pain Relevance 0.50
We went further to determine whether BCG treatment alters cytokine gene expression in the urinary bladder.


Gene_expression (expression) of cytokine gene in urinary bladder associated with cytokine
10) Confidence 0.01 Published 2007 Journal BMC Immunol Section Abstract Doc Link PMC1891101 Disease Relevance 0.56 Pain Relevance 0.46
It is unclear from the present study why SMTP-7 suppresses inflammatory cytokine mRNA expression.
Gene_expression (expression) of cytokine mRNA associated with inflammation and cytokine
11) Confidence 0.01 Published 2010 Journal Naunyn Schmiedebergs Arch Pharmacol Section Body Doc Link PMC2926440 Disease Relevance 1.53 Pain Relevance 0.82
Furthermore, the expressions of inflammatory cytokine mRNA (IL-1?
Gene_expression (expressions) of cytokine mRNA associated with inflammation and cytokine
12) Confidence 0.01 Published 2010 Journal Naunyn Schmiedebergs Arch Pharmacol Section Abstract Doc Link PMC2926440 Disease Relevance 1.04 Pain Relevance 0.29
In summary, parthenolide selectively modulated proinflammatory cytokine gene expression in vivo.
Gene_expression (expression) of cytokine gene associated with cytokine
13) Confidence 0.01 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1185559 Disease Relevance 0.15 Pain Relevance 0.18
Parthenolide's effects on specific cytokine gene expression have been documented in vitro, but, to our knowledge, few data are available regarding effects on mRNA expression of cytokines or other inflammatory genes such as COX-2 in vivo.
Gene_expression (expression) of cytokine gene associated with inflammation and cytokine
14) Confidence 0.01 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1185559 Disease Relevance 0.31 Pain Relevance 0.37
NF-kappaB activity was induced in transgenic acinar cells compared with controls contributing to high levels of chemokine and cytokine gene expression such as CCR-1 and CCL3.
Gene_expression (expression) of cytokine gene in acinar cells associated with targeted disruption, chemokine and cytokine
15) Confidence 0.01 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17546589 Disease Relevance 0.52 Pain Relevance 0.28
Cytokine gene expression in peripheral blood mononuclear cells reflects a systemic immune response in alcoholic chronic pancreatitis.
Gene_expression (expression) of Cytokine gene in blood associated with chronic pancreatitis and cytokine
16) Confidence 0.00 Published 1999 Journal Int. J. Pancreatol. Section Title Doc Link 10732290 Disease Relevance 0.10 Pain Relevance 0.33

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