INT60693

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Context Info
Confidence 0.02
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.73
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pglyrp1) extracellular region (Pglyrp1) cytoplasm (Pglyrp1)
Anatomy Link Frequency
acinar cells 4
peritoneal cavity 2
skin 2
Pglyrp1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 47 100.00 Very High Very High Very High
chemokine 3 100.00 Very High Very High Very High
Pain 15 97.52 Very High Very High Very High
Inflammation 41 94.92 High High
Thermal hyperalgesia 18 92.92 High High
Inflammatory response 2 75.00 Quite High
IPN 16 67.96 Quite High
Chronic pancreatitis 2 56.68 Quite High
Hyperalgesia 8 54.16 Quite High
cINOD 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 36 99.26 Very High Very High Very High
Cancer 3 97.64 Very High Very High Very High
Pain 14 97.52 Very High Very High Very High
Necrosis 3 97.40 Very High Very High Very High
INFLAMMATION 43 94.92 High High
Severe Combined Immunodeficiency 9 94.28 High High
Hyperalgesia 33 92.92 High High
Inflammatory Pain 17 67.96 Quite High
Pancreatitis 2 56.68 Quite High
Pancreatic Cancer 2 55.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At 24 hr, a massive neutrophil recruitment and an induced expression of a wide spectrum of murine cytokine mRNA (i.e., interleukin [IL]-1 beta, IL-4, IL-6, IL-10, IL-12, tumor necrosis factor [TNF]-alpha and interferon [IFN]-gamma) occurred in the huPBL-SCID mouse peritoneal cavity.
Positive_regulation (induced) of Gene_expression (expression) of cytokine mRNA in peritoneal cavity associated with necrosis, cancer, severe combined immunodeficiency and cytokine
1) Confidence 0.02 Published 1995 Journal Transplantation Section Abstract Doc Link 8525526 Disease Relevance 0.68 Pain Relevance 0.13
CFA increases both NOS and cytokine gene expression in plantar skin
Positive_regulation (increases) of Gene_expression (expression) of cytokine gene in skin associated with cytokine
2) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2838835 Disease Relevance 1.00 Pain Relevance 1.02
NF-kappaB activity was induced in transgenic acinar cells compared with controls contributing to high levels of chemokine and cytokine gene expression such as CCR-1 and CCL3.
Positive_regulation (levels) of Gene_expression (expression) of cytokine gene in acinar cells associated with targeted disruption, chemokine and cytokine
3) Confidence 0.00 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17546589 Disease Relevance 0.52 Pain Relevance 0.28
NF-kappaB activity was induced in transgenic acinar cells compared with controls contributing to high levels of chemokine and cytokine gene expression such as CCR-1 and CCL3.
Positive_regulation (contributing) of Gene_expression (expression) of cytokine gene in acinar cells associated with targeted disruption, chemokine and cytokine
4) Confidence 0.00 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17546589 Disease Relevance 0.53 Pain Relevance 0.29

General Comments

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