INT60694

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 1995
Last Reported 2011
Negated 14
Speculated 15
Reported most in Abstract
Documents 567
Total Number 584
Disease Relevance 369.48
Pain Relevance 143.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10) extracellular region (Il10) intracellular (Il10)
Anatomy Link Frequency
T cells 53
macrophages 28
lung 15
Kupffer cells 11
monocytes 10
Il10 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 9816 100.00 Very High Very High Very High
cytokine 9772 100.00 Very High Very High Very High
chemokine 823 100.00 Very High Very High Very High
antagonist 363 100.00 Very High Very High Very High
Dismenorea 12 100.00 Very High Very High Very High
Spinal cord 853 99.98 Very High Very High Very High
Inflammatory mediators 416 99.96 Very High Very High Very High
Arthritis 855 99.84 Very High Very High Very High
Opioid 17 99.84 Very High Very High Very High
methotrexate 239 99.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 10626 100.00 Very High Very High Very High
Cancer 3804 100.00 Very High Very High Very High
Targeted Disruption 2368 100.00 Very High Very High Very High
Fibrosis 1670 100.00 Very High Very High Very High
Necrosis 682 100.00 Very High Very High Very High
Dysmenorrhea 10 100.00 Very High Very High Very High
Epstein-barr Virus 608 99.92 Very High Very High Very High
Arthritis 849 99.84 Very High Very High Very High
Diabetes Mellitus 675 99.84 Very High Very High Very High
Atherosclerosis 215 99.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our aim was to investigate the role of adrenoceptors in the modulation of in vivo interleukin-10 (IL-10) production in lipopolysaccharide (LPS)-treated mice.
Gene_expression (production) of interleukin-10
1) Confidence 0.78 Published 2000 Journal Neuroreport Section Abstract Doc Link 11095519 Disease Relevance 0 Pain Relevance 0.20
Our aim was to investigate the role of adrenoceptors in the modulation of in vivo interleukin-10 (IL-10) production in lipopolysaccharide (LPS)-treated mice.
Gene_expression (production) of IL-10
2) Confidence 0.78 Published 2000 Journal Neuroreport Section Abstract Doc Link 11095519 Disease Relevance 0 Pain Relevance 0.20
Our results provide the first in vivo evidence that, in addition to beta-adrenoceptors; alpha-adrenoceptors play also a very important role in the regulation of IL-10 production under endotoxaemic conditions.
Gene_expression (production) of IL-10
3) Confidence 0.78 Published 2000 Journal Neuroreport Section Abstract Doc Link 11095519 Disease Relevance 0 Pain Relevance 0.26
Our results confirmed the involvement of beta-adrenoceptors since the beta-agonist isoproterenol significantly increased the IL-10 production in response to LPS stimulation, whereas the beta-antagonists propranolol decreased it.
Gene_expression (production) of IL-10 associated with antagonist and agonist
4) Confidence 0.78 Published 2000 Journal Neuroreport Section Abstract Doc Link 11095519 Disease Relevance 0 Pain Relevance 0.27
Opposite role of alpha2- and beta-adrenoceptors in the modulation of interleukin-10 production in endotoxaemic mice.
Gene_expression (production) of interleukin-10
5) Confidence 0.78 Published 2000 Journal Neuroreport Section Title Doc Link 11095519 Disease Relevance 0 Pain Relevance 0.23
Therefore, the absence of IL-10 expression accelerates the kinetics of lesion expansion, the onset of pain behaviors, and the peripheral immune response to spinal cord injury.
Gene_expression (expression) of IL-10 in spinal cord associated with pain and spinal cord
6) Confidence 0.78 Published 2004 Journal Neuroscience Section Abstract Doc Link 15026134 Disease Relevance 1.22 Pain Relevance 0.63
However, the role of endogenous production of IL-10 has not been considered.
Gene_expression (production) of IL-10
7) Confidence 0.78 Published 2004 Journal Neuroscience Section Abstract Doc Link 15026134 Disease Relevance 0.72 Pain Relevance 0.36
OBJECTIVE: To investigate the expression of interleukin-10 (IL-10) in adenomyosis.
Spec (investigate) Gene_expression (expression) of interleukin-10 associated with dismenorea
8) Confidence 0.78 Published 2009 Journal Fertil. Steril. Section Abstract Doc Link 18439592 Disease Relevance 0.17 Pain Relevance 0.17
Expression of interleukin-10 in patients with adenomyosis.
Gene_expression (Expression) of interleukin-10 associated with dismenorea
9) Confidence 0.78 Published 2009 Journal Fertil. Steril. Section Title Doc Link 18439592 Disease Relevance 0.10 Pain Relevance 0.20
OBJECTIVE: To investigate the expression of interleukin-10 (IL-10) in adenomyosis.
Spec (investigate) Gene_expression (expression) of IL-10 associated with dismenorea
10) Confidence 0.78 Published 2009 Journal Fertil. Steril. Section Abstract Doc Link 18439592 Disease Relevance 0.17 Pain Relevance 0.17
MAIN OUTCOME MEASURE(S): Microscopic evaluation to assess the presence and localization of IL-10 throughout the menstrual cycle in both eutopic endometrial and adenomyotic tissues of women with adenomyosis and compare it with IL-10 expression in the normal endometrium.
Gene_expression (expression) of IL-10 in endometrium
11) Confidence 0.78 Published 2009 Journal Fertil. Steril. Section Body Doc Link 18439592 Disease Relevance 0.08 Pain Relevance 0
Some IL-10 was produced but only from non-T cells.
Gene_expression (produced) of IL-10 in T cells
12) Confidence 0.78 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15246967 Disease Relevance 0.62 Pain Relevance 0.34
Epstein-Barr virus (EBV) takes advantage of the immunomodulatory effects of IL-10 by expressing a viral homolog of IL-10 during infections [6].
Gene_expression (expressing) of IL-10 associated with epstein-barr virus and infection
13) Confidence 0.78 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2749443 Disease Relevance 0.75 Pain Relevance 0.11
We found that CD4+ T cells produce a significant amount of IL-10 and may be a major cellular source of IL-10 in vivo during WNV infection.
Gene_expression (produce) of IL-10 in T cells associated with infection
14) Confidence 0.78 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2749443 Disease Relevance 0.54 Pain Relevance 0
Our data also indicate that macrophages produce IL-10 when exposed to WNV ex vivo (Figure 1 A and B), which is consistent with in vivo results showing that CD11b+ macrophages produce low levels of IL-10.
Gene_expression (produce) of IL-10 in macrophages
15) Confidence 0.78 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2749443 Disease Relevance 0.39 Pain Relevance 0
Our data also indicate that macrophages produce IL-10 when exposed to WNV ex vivo (Figure 1 A and B), which is consistent with in vivo results showing that CD11b+ macrophages produce low levels of IL-10.
Gene_expression (produce) of IL-10 in macrophages
16) Confidence 0.78 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2749443 Disease Relevance 0.44 Pain Relevance 0
However, excessive IL-10 production suppresses host immune responses and can inadvertently facilitate the ability of intracellular pathogens to escape host innate immune defenses.
Gene_expression (production) of IL-10
17) Confidence 0.78 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2749443 Disease Relevance 0.73 Pain Relevance 0.09
In addition, recent studies showed that lymphocytic choriomeningitis virus (LCMV) clone 13 elicits high levels of IL-10 production from the infected host, thereby resulting in exhaustion of virus-specific T cells and viral persistence [7]–[9].
Gene_expression (production) of IL-10 in T cells associated with lymphocytic choriomeningitis
18) Confidence 0.78 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2749443 Disease Relevance 0.67 Pain Relevance 0.11
Intrapancreatic IL-10 gene expression was assessed by semiquantitative RT-PCR, and intrapancreatic collagen content was assessed by picrosirius staining.
Gene_expression (expression) of IL-10 gene
19) Confidence 0.76 Published 2002 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12016137 Disease Relevance 1.08 Pain Relevance 0.30
Finally, two independent reports have demonstrated that blockade of the IL-10 receptor during chronic lymphocytic choriomeningitis virus infection led to clearance of the infection with enhanced IL-10 production by dendritic cells [63],[64].
Gene_expression (production) of IL-10 in dendritic cells associated with lymphocytic choriomeningitis and infection
20) Confidence 0.76 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.88 Pain Relevance 0.12

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox