INT60695

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1995
Last Reported 2011
Negated 4
Speculated 1
Reported most in Body
Documents 154
Total Number 159
Disease Relevance 120.28
Pain Relevance 43.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10) extracellular region (Il10) intracellular (Il10)
Anatomy Link Frequency
macrophage 23
T cells 21
lung 14
monocytes 8
brain 7
Il10 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 2784 100.00 Very High Very High Very High
cytokine 2489 100.00 Very High Very High Very High
antagonist 96 100.00 Very High Very High Very High
metalloproteinase 70 100.00 Very High Very High Very High
methotrexate 65 99.98 Very High Very High Very High
Arthritis 361 99.84 Very High Very High Very High
adenocard 90 99.84 Very High Very High Very High
fibrosis 605 99.76 Very High Very High Very High
cINOD 106 99.68 Very High Very High Very High
Paracetamol 35 99.58 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2943 100.00 Very High Very High Very High
Cancer 934 100.00 Very High Very High Very High
Fibrosis 488 100.00 Very High Very High Very High
Necrosis 127 100.00 Very High Very High Very High
Infection 1550 99.98 Very High Very High Very High
Targeted Disruption 883 99.98 Very High Very High Very High
Pulmonary Fibrosis 437 99.96 Very High Very High Very High
Renal Cancer 2 99.96 Very High Very High Very High
Arthritis 348 99.84 Very High Very High Very High
Atherosclerosis 44 99.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results confirmed the involvement of beta-adrenoceptors since the beta-agonist isoproterenol significantly increased the IL-10 production in response to LPS stimulation, whereas the beta-antagonists propranolol decreased it.
Positive_regulation (increased) of Gene_expression (production) of IL-10 associated with antagonist and agonist
1) Confidence 0.70 Published 2000 Journal Neuroreport Section Abstract Doc Link 11095519 Disease Relevance 0 Pain Relevance 0.27
Finally, two independent reports have demonstrated that blockade of the IL-10 receptor during chronic lymphocytic choriomeningitis virus infection led to clearance of the infection with enhanced IL-10 production by dendritic cells [63],[64].
Positive_regulation (enhanced) of Gene_expression (production) of IL-10 in dendritic cells associated with lymphocytic choriomeningitis and infection
2) Confidence 0.68 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.89 Pain Relevance 0.12
Similar differences to the in vivo results were observed in LPS-induced IL-10 production of Kupffer cells between GF and CV mice.
Positive_regulation (-) of Gene_expression (production) of IL-10 in Kupffer cells
3) Confidence 0.68 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2243250 Disease Relevance 0.12 Pain Relevance 0.19
LPS-induced IL-10 production in Kupffer cells
Positive_regulation (-) of Gene_expression (production) of IL-10 in Kupffer cells
4) Confidence 0.68 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2243250 Disease Relevance 0.07 Pain Relevance 0.07
These facts suggest that since oral administration of LPS or bacterial flora might alter the IL-10 production, serum IL-10 production could be enhanced in GF mice.
Positive_regulation (enhanced) of Gene_expression (production) of IL-10
5) Confidence 0.68 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2243250 Disease Relevance 0 Pain Relevance 0.13
First, the IL-10 production into M phi culture fluids was temporarily increased around days 1 to 3, thereafter gradually declined, and returned to normal by day 14.
Positive_regulation (increased) of Gene_expression (production) of IL-10
6) Confidence 0.67 Published 1997 Journal Kansensh?gaku Zasshi Section Abstract Doc Link 9339628 Disease Relevance 0.67 Pain Relevance 0.74
Thirdly, the majority of test anti-inflammatory drugs, not only glucocorticoids but also NSAID, were found to up-regulate the IL-10 production of MAC-infected M phi s, suggesting some possible roles of IL-10 in the expression of the anti-inflammatory activities of these agents.
Positive_regulation (up-regulate) of Gene_expression (production) of IL-10 associated with inflammation and cinod
7) Confidence 0.67 Published 1997 Journal Kansensh?gaku Zasshi Section Abstract Doc Link 9339628 Disease Relevance 0.61 Pain Relevance 0.70
In conclusion, these findings suggest that an important feature of the normal response to drug-induced liver injury may be the increased expression of anti-inflammatory factors such as IL-10.
Positive_regulation (increased) of Gene_expression (expression) of IL-10 in liver associated with inflammation and injury
8) Confidence 0.66 Published 2002 Journal Hepatology Section Abstract Doc Link 11826401 Disease Relevance 1.37 Pain Relevance 0.89
Overexpression of IL-10 in a transgenic mouse model leads to macrophage-mediated demyelinating polyneuropathy.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of IL-10 in macrophage associated with neuropathy, targeted disruption and demyelinating disease
9) Confidence 0.65 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2743195 Disease Relevance 1.58 Pain Relevance 0.21
First, overexpression of IL-10 results in upregulation of ICAM-1 on sciatic nerve tissue.
Positive_regulation (overexpression) of Gene_expression (overexpression) of IL-10 in sciatic nerve associated with sciatic nerve
10) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743195 Disease Relevance 1.06 Pain Relevance 0.28
S2G), despite the increased expression of VMD2 and IL-10 in the eyes of these animals.
Positive_regulation (increased) of Gene_expression (expression) of IL-10 in eyes
11) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743195 Disease Relevance 0.53 Pain Relevance 0.19
Although IL-10 is an immunosuppressive cytokine at normal levels, overexpression of IL-10 exacerbates inflammation.
Positive_regulation (overexpression) of Gene_expression (overexpression) of IL-10 associated with inflammation and cytokine
12) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743195 Disease Relevance 1.46 Pain Relevance 0.53
Collectively, our results are consistent with a model in which absence of MMP-8 results in increased inflammation, but also increased levels of IL-10.
Positive_regulation (increased) of Gene_expression (levels) of IL-10 associated with inflammation
13) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2951918 Disease Relevance 0.68 Pain Relevance 0.26
Under physiological conditions, adrenergic stimulation has been shown to be a negative regulator of proinflammatory cytokine production through increasing IL-10 production.
Positive_regulation (increasing) of Gene_expression (production) of IL-10 associated with cytokine
14) Confidence 0.61 Published 2004 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 15151906 Disease Relevance 0.33 Pain Relevance 0.21
As already observed, a persisting increase of IL-10 production was observed in the FA model (silica) which paralleled the establishment of lung fibrosis (Figure 5 A).
Positive_regulation (increase) of Gene_expression (production) of IL-10 in lung associated with fibrosis and pulmonary fibrosis
15) Confidence 0.58 Published 2005 Journal Respir Res Section Body Doc Link PMC1274346 Disease Relevance 1.70 Pain Relevance 0.51
A significant and dose-dependent increase of IL-10 production was observed in lung homogenates of silica-treated mice at day 60 (Figure 4 D).
Positive_regulation (increase) of Gene_expression (production) of IL-10 in lung
16) Confidence 0.58 Published 2005 Journal Respir Res Section Body Doc Link PMC1274346 Disease Relevance 0.34 Pain Relevance 0.22
These observations also suggested that the limited lung inflammation observed in mice could be related, at least in part, to their increased expression of IL-10.


Positive_regulation (increased) of Gene_expression (expression) of IL-10 in lung associated with inflammation and pneumonia
17) Confidence 0.58 Published 2005 Journal Respir Res Section Body Doc Link PMC1274346 Disease Relevance 0.74 Pain Relevance 0.41
Recent work from this laboratory showed that, in mice treated with silica, lung overexpression of IL-10 upregulated the production of other Th2 cytokines such as IL-4 and IL-13.
Positive_regulation (overexpression) of Gene_expression (overexpression) of IL-10 in lung associated with cytokine
18) Confidence 0.58 Published 2005 Journal Respir Res Section Body Doc Link PMC1274346 Disease Relevance 0.61 Pain Relevance 0.31
Together with our previous observations demonstrating a pro-fibrotic activity of IL-10 in the lung of mice treated with silica particles [14,24,49], we can conclude that the overexpression of IL-10 documented in the lung of mice in the present study contributed to the establishment of the fibrotic response.
Positive_regulation (overexpression) of Gene_expression (overexpression) of IL-10 in lung associated with fibrosis
19) Confidence 0.58 Published 2005 Journal Respir Res Section Body Doc Link PMC1274346 Disease Relevance 1.09 Pain Relevance 0.21
An obvious association between the extent of IL-10 overexpression and the amplitude of fibrosis was shown in this study.
Positive_regulation (overexpression) of Gene_expression (overexpression) of IL-10 associated with fibrosis
20) Confidence 0.58 Published 2005 Journal Respir Res Section Body Doc Link PMC1274346 Disease Relevance 1.47 Pain Relevance 0.55

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox