INT60700

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Context Info
Confidence 0.71
First Reported 1995
Last Reported 2011
Negated 4
Speculated 3
Reported most in Body
Documents 93
Total Number 97
Disease Relevance 51.89
Pain Relevance 6.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgax)
Anatomy Link Frequency
T cells 22
lung 12
macrophage 4
N418 4
spleen 4
Itgax (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 7 99.80 Very High Very High Very High
narcan 2 99.60 Very High Very High Very High
Inflammation 715 98.24 Very High Very High Very High
cytokine 480 97.20 Very High Very High Very High
opiate 2 96.76 Very High Very High Very High
Central nervous system 131 96.08 Very High Very High Very High
Chronic pancreatitis 10 95.92 Very High Very High Very High
chemokine 93 93.08 High High
Analgesic 6 90.64 High High
vincristine 5 90.64 High High
Disease Link Frequency Relevance Heat
Respiratory Syncytial Virus 2358 99.80 Very High Very High Very High
Infection 2208 99.80 Very High Very High Very High
Bites And Stings 10 99.60 Very High Very High Very High
Mycobacterial Infection 302 99.56 Very High Very High Very High
Candida Infection 137 99.08 Very High Very High Very High
Lymphatic System Cancer 83 98.80 Very High Very High Very High
Amyloid Plaque 23 98.64 Very High Very High Very High
Chronic Lymphoid Leukemia 25 98.60 Very High Very High Very High
Pneumonia 45 98.44 Very High Very High Very High
Leukemia 15 98.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Having observed striking increases of CD8+ T cells expressing CD11c in the lung following RSV infection we asked if these cells are phenotypically different regarding their activation status compared to CD11c- CD8+ T cells.
Gene_expression (expressing) of CD11c in T cells associated with infection and respiratory syncytial virus
1) Confidence 0.71 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 0.72 Pain Relevance 0.09
Since both CD11c and CD80 are expressed widely on murine APC we asked whether the presence of CD11c on CD8+ T cells is due to expression by T cells rather than to membrane transfer from APC during T cell priming.
Gene_expression (expressed) of CD11c in T cell
2) Confidence 0.71 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 0.47 Pain Relevance 0
Again CD11c expression was much lower in MLN, spleen or blood and was not increased on CD3+CD8- cells (data not shown).
Gene_expression (expression) of CD11c in spleen
3) Confidence 0.71 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 1.19 Pain Relevance 0.11
To analyze if CD11c is also expressed on T cells in other organs than the lung during RSV infection, CD8+ T cells were monitored in MLN, spleen and blood.
Gene_expression (expressed) of CD11c in spleen associated with infection and respiratory syncytial virus
4) Confidence 0.71 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 1.05 Pain Relevance 0
CD11c mRNA seems to be expressed constitutively in CD8+ T cells while expression of CD11c protein on the cell surface requires activation.
Gene_expression (expression) of CD11c in T cells
5) Confidence 0.71 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 0.37 Pain Relevance 0.03
Here, we demonstrate that following RSV infection a population of CTL co-expresses CD11ahi, CD11b and CD11c.
Gene_expression (expresses) of CD11c associated with infection and respiratory syncytial virus
6) Confidence 0.71 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 0.81 Pain Relevance 0.07
In this setting, only 3.8 ± 1.0% of CD8+ T cells expressed CD11c and no changes were observed in the CD3+ CD8- population.
Gene_expression (expressed) of CD11c in T cells
7) Confidence 0.71 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 1.05 Pain Relevance 0.14
In naïve (Figure 1a, c) as well as mock-infected mice (data not shown) only as little as 0.7 ± 0.3% of pulmonary CD8+ T cells expressed CD11c.
Gene_expression (expressed) of CD11c in T cells
8) Confidence 0.71 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 0.93 Pain Relevance 0
Only in MLN, numbers of CD8+ T cells expressing CD11c remained significantly elevated on dpi 10 (Figure 1c).
Gene_expression (expressing) of CD11c in T cells
9) Confidence 0.71 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 1.12 Pain Relevance 0
Interestingly, expression of CD11c was hardly increased on CD3+ CD8- cells (Figure 1a), consisting mostly of CD4+ T cells (data not shown).
Gene_expression (expression) of CD11c in T cells
10) Confidence 0.71 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 0.90 Pain Relevance 0
CD8+ cells were purified from lungs and spleens of RSV-infected or naïve mice, RNA was isolated and the expression of CD11c analyzed by quantitative PCR.
Spec (analyzed) Gene_expression (expression) of CD11c in spleens associated with respiratory syncytial virus
11) Confidence 0.71 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 0.59 Pain Relevance 0
Following RSV infection, numbers of CD11c+ CD8+ T cells increased significantly until dpi 8 when 45.9 ± 4.8% of CD8+ T cells expressed CD11c and declined thereafter.
Gene_expression (expressed) of CD11c in T cells associated with infection and respiratory syncytial virus
12) Confidence 0.71 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 0.91 Pain Relevance 0
Kinetics of CD11b expression on T cells paralleled CD11c expression, with lower percentages of CD11b+ CD8+ T cells in the lungs on dpi 8 and 10 (Figure 1c).
Gene_expression (expression) of CD11c in lungs
13) Confidence 0.71 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 1.05 Pain Relevance 0.12
Since both primary and secondary RSV infection resulted in appearance of CD8+ CD11c+ T cells we asked if CD11c expression on T cells is a general phenomenon in lung inflammation irrespective of etiology.
Gene_expression (expression) of CD11c in lung associated with inflammation, pneumonia, infection and respiratory syncytial virus
14) Confidence 0.71 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 1.22 Pain Relevance 0.14
We hypothesized that CD11c is a marker of antigen-specific cytotoxic T cells, which is expressed following activation, rather than being transferred from APC during cell-cell interactions.
Gene_expression (expressed) of CD11c in cytotoxic T cells
15) Confidence 0.71 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 0.78 Pain Relevance 0
In two separate experiments, expression levels of CD11c normalized to GAPDH were nearly equal in CD11c+ (relative expression = 1.05 ± 0.06, n = 4) and CD8+ (relative expression = 1.08 ± 0.03) cells from the lung following RSV infection.
Gene_expression (expression) of CD11c in lung associated with infection and respiratory syncytial virus
16) Confidence 0.71 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 0.71 Pain Relevance 0
Next, we asked if expression of CD11c on CD8+ T cells is unique to primary infection.
Gene_expression (expression) of CD11c in T cells associated with infection
17) Confidence 0.71 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 1.23 Pain Relevance 0.06
As CD11c expression is associated with activation of virus-specific T cells but does not seem to have a specific, non-redundant function in cytotoxic activity, we asked if CD11c may be involved in migration of these cells to the lung.
Gene_expression (expression) of CD11c in lung
18) Confidence 0.71 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 0.89 Pain Relevance 0
The cells were stained with the following rat anti-mouse monoclonal antibodies: APC anti-CD11c (clone N418) and PE anti-NK 1.1 (clone PK136) from eBioscience; R-R-PE anti-CD8?
Gene_expression (anti) of N418 in N418
19) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776531 Disease Relevance 0 Pain Relevance 0
The cells were stained with the following rat anti-mouse monoclonal antibodies: APC anti-CD11c (clone N418) and PE anti-NK 1.1 (clone PK136) from eBioscience; R-R-PE anti-CD8?
Gene_expression (stained) of N418 in N418
20) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776531 Disease Relevance 0 Pain Relevance 0

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