INT60710

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Context Info
Confidence 0.78
First Reported 1995
Last Reported 2011
Negated 6
Speculated 1
Reported most in Abstract
Documents 217
Total Number 218
Disease Relevance 113.20
Pain Relevance 35.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Col7a1) cell adhesion (Col7a1) proteinaceous extracellular matrix (Col7a1)
Anatomy Link Frequency
lung 19
fibroblast 15
skin 7
joints 5
platelet 4
Col7a1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1371 100.00 Very High Very High Very High
metalloproteinase 513 100.00 Very High Very High Very High
agonist 65 99.92 Very High Very High Very High
fibrosis 2555 99.80 Very High Very High Very High
Arthritis 1043 99.60 Very High Very High Very High
rheumatoid arthritis 886 99.46 Very High Very High Very High
Chronic pancreatitis 120 99.46 Very High Very High Very High
Inflammation 2815 99.20 Very High Very High Very High
Catecholamine 1 99.20 Very High Very High Very High
anesthesia 132 98.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Immunization 152 100.00 Very High Very High Very High
Hepatitis 36 100.00 Very High Very High Very High
Urological Neuroanatomy 4 100.00 Very High Very High Very High
Hyperplasia 103 99.96 Very High Very High Very High
Apoptosis 591 99.90 Very High Very High Very High
Fibrosis 2096 99.84 Very High Very High Very High
Adenoma 2 99.84 Very High Very High Very High
Disease 1122 99.80 Very High Very High Very High
Asthma 252 99.80 Very High Very High Very High
Osteoporosis 144 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A significant increase of collagen synthesis was observed in group L compared with C (168 +/- 20 vs 63 +/- 8 mm(2)).
Gene_expression (synthesis) of collagen
1) Confidence 0.78 Published 2007 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 17581688 Disease Relevance 0.53 Pain Relevance 0.26
Collagen biosynthesis was analyzed in C57BL/6J mice homozygous for the high-growth locus.
Spec (analyzed) Gene_expression (biosynthesis) of Collagen
2) Confidence 0.69 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8853393 Disease Relevance 0 Pain Relevance 0.11
Collagen, expressed per weight of tissue, was significantly increased in all tissues from high-growth mice, as was collagen cross-linking, expressed as moles of cross-link per mole of collagen.
Gene_expression (expressed) of Collagen
3) Confidence 0.69 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8853393 Disease Relevance 0 Pain Relevance 0.18
In summary, elevated levels of IGF-1 appear to affect collagen both quantitatively and qualitatively, primarily through their effects on gene expression of collagen and of those enzymes responsible for posttranslational modifications of collagen.
Gene_expression (expression) of collagen
4) Confidence 0.69 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8853393 Disease Relevance 0 Pain Relevance 0.11
Intense disorganisation of collagen fibres was observed 1 min after the venom injection, particularly at regions near vessels and nerves.
Gene_expression (fibres) of collagen in nerves
5) Confidence 0.65 Published 2000 Journal Mediators Inflamm Section Abstract Doc Link PMC1781750 Disease Relevance 0.37 Pain Relevance 0.13
These results suggest that 1) elevated circulating IGF-1 may increase collagen deposition both in normal tissue as well as in granulation tissue by increasing collagen gene expression, 2) IGF-1 may increase collagen cross-linking by stimulating expression of lysyl oxidase, and 3) the preferential increase in dihydroxylated cross-links observed in high-growth mice may be due to the stimulation of lysyl hydroxylase expression by IGF-1.
Gene_expression (expression) of collagen in granulation
6) Confidence 0.60 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8853393 Disease Relevance 0 Pain Relevance 0.15
Expression of types I and III collagen, lysyl oxidase, and lysyl hydroxylase was increased in all tissues analyzed.
Gene_expression (Expression) of collagen
7) Confidence 0.60 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8853393 Disease Relevance 0 Pain Relevance 0.18
Thus, type VI collagen is abundant in the synovium of the mouse mandibular joint and is associated with proteoglycans or glycosaminoglycans, which might have a role in its formation.
Gene_expression (abundant) of collagen in joint
8) Confidence 0.57 Published 1995 Journal Arch. Oral Biol. Section Abstract Doc Link 8526809 Disease Relevance 0.07 Pain Relevance 0.07
We have not studied the COL1A1 gene in our population, but the increased Smax, which indicates altered collagen properties in CI-patients, could reflect the findings by Warren et al.
Gene_expression (properties) of collagen
9) Confidence 0.54 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2927597 Disease Relevance 0.09 Pain Relevance 0
The biomechanical properties of a tissue are determined not only by the collagen concentration but also by the collagen composition, the cross links, and the presence of other extracellular macromolecules like decorin and versican [26] whereas muscle cells only contribute insignificantly [27].
Gene_expression (composition) of collagen in muscle cells
10) Confidence 0.54 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2927597 Disease Relevance 0.05 Pain Relevance 0
The biomechanical properties of a tissue are determined not only by the collagen concentration but also by the collagen composition, the cross links, and the presence of other extracellular macromolecules like decorin and versican [26] whereas muscle cells only contribute insignificantly [27].
Gene_expression (composition) of collagen in muscle cells
11) Confidence 0.54 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2927597 Disease Relevance 0.05 Pain Relevance 0
In order to describe the tensile strength of cervical collagen, maximum load was divided by collagen content in mg of collagen per mm of specimen length.
Gene_expression (content) of collagen
12) Confidence 0.54 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2927597 Disease Relevance 0 Pain Relevance 0
Determination of collagen orientation
Gene_expression (orientation) of collagen
13) Confidence 0.54 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2927597 Disease Relevance 0 Pain Relevance 0.05
In order to describe the tensile strength of cervical collagen, maximum load was divided by collagen content in mg of collagen per mm of specimen length.
Gene_expression (content) of collagen
14) Confidence 0.54 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2927597 Disease Relevance 0 Pain Relevance 0
Collagen, expressed per weight of tissue, was significantly increased in all tissues from high-growth mice, as was collagen cross-linking, expressed as moles of cross-link per mole of collagen.
Gene_expression (expressed) of collagen
15) Confidence 0.54 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8853393 Disease Relevance 0 Pain Relevance 0.18
Collagen, expressed per weight of tissue, was significantly increased in all tissues from high-growth mice, as was collagen cross-linking, expressed as moles of cross-link per mole of collagen.
Gene_expression (expressed) of collagen
16) Confidence 0.54 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8853393 Disease Relevance 0 Pain Relevance 0.18
Therefore in this study the results by low dose collagen aggregometry might be influenced by not only aspirin resistance but also the difference of the preoperative disease activity expressed on both baseline myocardial enzyme and low dose collagen aggregometry.
Gene_expression (expressed) of collagen associated with aspirin and disease
17) Confidence 0.48 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872863 Disease Relevance 0.38 Pain Relevance 0.33
Damaged endothelium exposes the subendothelial collagen, a platelet agonist, and activated platelet generates microemboli, which may be an important mechanism of myocardial injury [8].
Gene_expression (exposes) of collagen in platelet associated with injury and agonist
18) Confidence 0.48 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872863 Disease Relevance 0.55 Pain Relevance 0.16
A human skin substitute consisting of human cultured keratinocytes, collagen dermis, and fibrin was evaluated in athymic mice.
Gene_expression (dermis) of collagen in dermis
19) Confidence 0.41 Published 1999 Journal Ann Plast Surg Section Abstract Doc Link 10560869 Disease Relevance 0.22 Pain Relevance 0.08
Ulrich et al35 found that the balance between MMPs and TIMPs is disturbed in patients with capsule contracture thus causing alteration in synthesis and deposition of collagen surrounding implants.36
Gene_expression (synthesis) of collagen in capsule associated with metalloproteinase and contracture
20) Confidence 0.38 Published 2010 Journal Eplasty Section Body Doc Link PMC2948451 Disease Relevance 0.70 Pain Relevance 0.42

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