INT60714

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.04
First Reported 1995
Last Reported 2008
Negated 2
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.64
Pain Relevance 3.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Homer1) cytoplasm (Homer1)
Anatomy Link Frequency
nucleus accumbens 2
neurons 2
striatum 2
Homer1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 14 100.00 Very High Very High Very High
Dopamine 11 100.00 Very High Very High Very High
Opioid 12 99.98 Very High Very High Very High
dopamine receptor 7 99.72 Very High Very High Very High
agonist 8 98.64 Very High Very High Very High
Enkephalin 20 98.56 Very High Very High Very High
Nucleus accumbens 51 98.40 Very High Very High Very High
narcan 6 98.22 Very High Very High Very High
projection neuron 6 92.44 High High
opioid receptor 7 88.96 High High
Disease Link Frequency Relevance Heat
Parkinson's Disease 6 96.24 Very High Very High Very High
Disease 4 83.52 Quite High
Hypersensitivity 2 5.00 Very Low Very Low Very Low
Drug Dependence 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The induction of the immediate early gene c-fos by the dopamine D2 receptor antagonist haloperidol was not altered, while the selective D1 receptor agonist SKF 38393 failed to induce c-fos in the striatum of MPTP-treated mice.
Neg (not) Regulation (altered) of Positive_regulation (induction) of immediate early gene in striatum associated with parkinson's disease, dopamine, antagonist and agonist
1) Confidence 0.04 Published 1995 Journal J Neural Transm Park Dis Dement Sect Section Abstract Doc Link 8527000 Disease Relevance 0.64 Pain Relevance 0.39
Sensitization of immediate-early gene activation in a specific neural population of the nucleus accumbens core
Regulation (Sensitization) of Positive_regulation (activation) of immediate-early gene in nucleus accumbens associated with nucleus accumbens
2) Confidence 0.03 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2362139 Disease Relevance 0 Pain Relevance 0.17
Naloxone reversed such behavioral recovery (i.e. reinstated akinesia), but did not significantly affect suppressed immediate-early gene induction.
Neg (not) Regulation (affect) of Neg (not) Positive_regulation (induction) of immediate-early gene associated with narcan
3) Confidence 0.01 Published 1999 Journal Neuroscience Section Abstract Doc Link 10363818 Disease Relevance 0 Pain Relevance 1.36
Here, we investigated whether enkephalin regulates the function of striatopallidal neurons, by analysing opioid effects on immediate-early gene induction by D2 dopamine receptor blockade that occurs in these neurons.
Spec (analysing) Regulation (effects) of Spec (analysing) Positive_regulation (induction) of immediate-early gene in neurons associated with dopamine receptor, enkephalin and opioid
4) Confidence 0.01 Published 1999 Journal Neuroscience Section Abstract Doc Link 10363818 Disease Relevance 0 Pain Relevance 1.54

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox