INT60719

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Context Info
Confidence 0.03
First Reported 1995
Last Reported 1995
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.23
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Fos) DNA binding (Fos) transcription factor binding (Fos)
kinase activity (Insrr)
Anatomy Link Frequency
striatum 1
Insrr (Mus musculus)
Fos (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 4 100.00 Very High Very High Very High
antagonist 4 99.96 Very High Very High Very High
Dopamine 6 98.48 Very High Very High Very High
Substantia nigra 6 94.12 High High
Enkephalin 4 25.00 Low Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 12 99.20 Very High Very High Very High
Disease 8 95.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The induction of the immediate early gene c-fos by the dopamine D2 receptor antagonist haloperidol was not altered, while the selective D1 receptor agonist SKF 38393 failed to induce c-fos in the striatum of MPTP-treated mice.
receptor Neg (failed) Positive_regulation (induce) of c-fos in striatum associated with parkinson's disease, dopamine, antagonist and agonist
1) Confidence 0.03 Published 1995 Journal J Neural Transm Park Dis Dement Sect Section Abstract Doc Link 8527000 Disease Relevance 0.63 Pain Relevance 0.42
In the striata of 6-OHDA-lesioned rats, PENK gene is upregulated, PDYN gene is down-regulated and the induction of c-fos gene by D2 receptor antagonists is abolished, whereas selective D1 receptor agonists induce c-fos gene, which does not occur in non-lesioned rats.
receptor Positive_regulation (induction) of c-fos gene associated with antagonist and agonist
2) Confidence 0.01 Published 1995 Journal J Neural Transm Park Dis Dement Sect Section Abstract Doc Link 8527000 Disease Relevance 0.60 Pain Relevance 0.42

General Comments

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