INT60724

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Context Info
Confidence 0.72
First Reported 1995
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 30
Total Number 38
Disease Relevance 27.00
Pain Relevance 5.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Psen2) endoplasmic reticulum (Psen2) embryo development (Psen2)
protein complex (Psen2) cytosol (Psen2) peptidase activity (Psen2)
Anatomy Link Frequency
brain 3
MCF-7 1
duct 1
neural 1
pancreas 1
Psen2 (Mus musculus)
Psen2 - N141I (4)
Pain Link Frequency Relevance Heat
bDMF 40 100.00 Very High Very High Very High
Chronic pancreatitis 12 99.98 Very High Very High Very High
Opioid 20 99.34 Very High Very High Very High
Inflammation 242 99.28 Very High Very High Very High
Hippocampus 76 99.24 Very High Very High Very High
Immobilon 14 98.96 Very High Very High Very High
Abeta 19 89.96 High High
Pyramidal cell 9 88.40 High High
Serotonin 46 86.00 High High
medulla 4 80.56 Quite High
Disease Link Frequency Relevance Heat
Disease 1592 100.00 Very High Very High Very High
Targeted Disruption 385 99.98 Very High Very High Very High
Cancer 57 99.98 Very High Very High Very High
Pancreatitis 12 99.98 Very High Very High Very High
Pancreatic Cancer 8 99.84 Very High Very High Very High
Alzheimer's Dementia 393 99.72 Very High Very High Very High
Body Weight 20 99.66 Very High Very High Very High
INFLAMMATION 352 99.28 Very High Very High Very High
Adenocarcinoma 8 99.26 Very High Very High Very High
Cognitive Disorder 216 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During mouse development, PS1 mRNA expression is particularly high in neural organs, whereas PS2 is barely expressed.
Gene_expression (expressed) of PS2 in neural
1) Confidence 0.72 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 0 Pain Relevance 0.21
40 ratio in cells or transgenic mice expressing mutant PS1 or PS2 genes (Selkoe, 2002).
Gene_expression (expressing) of PS2 associated with targeted disruption
2) Confidence 0.72 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 0.66 Pain Relevance 0
The finding of pS2 expression in more than 50% of pancreatic and ampullary carcinomas in contrast to the findings seen in chronic pancreatitis and normal pancreas suggests that pS2 may play an important role in the growth of these highly malignant tumours.
Gene_expression (expression) of pS2 in pancreas associated with malignant neoplastic disease, carcinoma and chronic pancreatitis
3) Confidence 0.71 Published 1995 Journal J. Gastroenterol. Hepatol. Section Abstract Doc Link 8527704 Disease Relevance 1.20 Pain Relevance 0.27
To address the potential impact of presenilin mutations on the prostaglandin metabolism in a neurodegenerative model of glutamatergic excitotoxicity, we injected kainic acid intraperitoneally (30mg/kg body weight) into mice over-expressing the human N141I mutation of presenilin-2, which is known to cause an early-onset form of Alzheimer's disease.
Gene_expression (expressing) of presenilin-2 (N141I) in body associated with body weight, disease and neurodegenerative disease
4) Confidence 0.69 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19560505 Disease Relevance 0.72 Pain Relevance 0.03
PS2M1 mice, which express human presenilin-2 (PS2) proteins containing the N141I mutation on a C57BL/6JJcl background, were also used [17].
Gene_expression (express) of presenilin-2
5) Confidence 0.68 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3018662 Disease Relevance 0.73 Pain Relevance 0
PS2M1 mice, which express human presenilin-2 (PS2) proteins containing the N141I mutation on a C57BL/6JJcl background, were also used [17].
Gene_expression (express) of PS2
6) Confidence 0.68 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3018662 Disease Relevance 0.73 Pain Relevance 0
The PS2 transgene is expressed under control of a ubiquitous CAGGS promoter consisting of cytomegalovirus early enhancer coupled with chicken ?
Gene_expression (expressed) of PS2 associated with cytomegalovirus infection
7) Confidence 0.68 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3018662 Disease Relevance 0.66 Pain Relevance 0
However, expression of chimeric PS1/PS2 holoprotein is endoproteolysed and forms heteromeric assemblies made of PS1NTF•PS2CTF [21].
Gene_expression (expression) of PS2
8) Confidence 0.68 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.14 Pain Relevance 0
In cells co-expressing PS1 and PS2, the assemblies consist of either of PS1 derivatives or PS2 derivatives but not mixed assemblies (for example, PS1NTF•PS2CTF).
Gene_expression (derivatives) of PS2
9) Confidence 0.65 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.15 Pain Relevance 0
By contrast, PS1 and PS2 mRNAs are highly expressed in neurons of the hippocampus and entorhinal cortex in adult mouse brain (Lee et al., 1996).
Gene_expression (expressed) of PS2 in cortex associated with hippocampus
10) Confidence 0.63 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 0 Pain Relevance 0.22
The aim of this study was to examine the expression of pS2 in pancreatic cancer.
Spec (examine) Gene_expression (expression) of pS2 associated with pancreatic cancer
11) Confidence 0.62 Published 1995 Journal J. Gastroenterol. Hepatol. Section Abstract Doc Link 8527704 Disease Relevance 0.79 Pain Relevance 0.15
No immunostaining was seen in normal pancreas, with the exception of one area of ductular proliferation, and although 8/10 cases of chronic pancreatitis expressed pS2, it was focal and confined to the occasional duct.
Gene_expression (expressed) of pS2 in duct associated with chronic pancreatitis
12) Confidence 0.62 Published 1995 Journal J. Gastroenterol. Hepatol. Section Abstract Doc Link 8527704 Disease Relevance 1.11 Pain Relevance 0.27
In the absence of PS1, transgenic expression of wild type PS2 neither increases A?
Gene_expression (expression) of PS2 associated with targeted disruption
13) Confidence 0.59 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.85 Pain Relevance 0
Here, we demonstrate that the PS2 mutation induced the early deposition of amyloid ?
Gene_expression (mutation) of PS2 associated with alzheimer's dementia
14) Confidence 0.59 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC3018662 Disease Relevance 0.86 Pain Relevance 0
The PS2 mutation also accelerated learning and memory impairment associated with A?
Gene_expression (mutation) of PS2 associated with cognitive disorder
15) Confidence 0.59 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC3018662 Disease Relevance 0.84 Pain Relevance 0
-secretase containing PS1 or PS2.
Gene_expression (containing) of PS2
16) Confidence 0.59 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.77 Pain Relevance 0
In contrast to PS1, not much information is available on the functions of PS2 or PS2-mediated ?
Gene_expression (functions) of PS2
17) Confidence 0.59 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.83 Pain Relevance 0.06
The lesser frequency of FAD-linked PS2 mutations compared to that of PS1 also suggests a redundant role for PS2 containing ?
Gene_expression (containing) of PS2 associated with disease
18) Confidence 0.59 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.84 Pain Relevance 0
In contrast to PS1, not much information is available on the functions of PS2 or PS2-mediated ?
Gene_expression (functions) of PS2
19) Confidence 0.59 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.82 Pain Relevance 0.06
Given that the AD genes PS1 and PS2 are also expressed in the heart [11], it may be speculated that mutations in these genes in familial AD affect cardiac function.
Gene_expression (expressed) of PS2 in heart associated with disease
20) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696039 Disease Relevance 2.22 Pain Relevance 0

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