INT60725

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Context Info
Confidence 0.42
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.49
Pain Relevance 4.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal 1
Tens1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
transcutaneous nerve stimulation 21 100.00 Very High Very High Very High
Analgesic 14 99.98 Very High Very High Very High
tolerance 11 99.64 Very High Very High Very High
Hyperalgesia 2 99.48 Very High Very High Very High
Cholecystokinin 10 99.08 Very High Very High Very High
Pain 72 98.28 Very High Very High Very High
withdrawal 2 97.84 Very High Very High Very High
Inflammation 4 92.40 High High
Pain management 1 88.48 High High
Spinal cord 2 87.40 High High
Disease Link Frequency Relevance Heat
Arthritis 2 99.84 Very High Very High Very High
Hyperalgesia 2 99.48 Very High Very High Very High
Pressure And Volume Under Development 4 98.48 Very High Very High Very High
Nociception 2 97.72 Very High Very High Very High
Pain 73 96.40 Very High Very High Very High
INFLAMMATION 5 92.40 High High
Sleep Disorders 1 68.44 Quite High
Vomiting 2 68.04 Quite High
Constipation 1 67.32 Quite High
Hemorrhage 1 64.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results suggest that TENS stimulation-induced reduction of c-fos expression may reflect an inhibition of spinal nociception.
Negative_regulation (reduction) of TENS in spinal associated with nociception and transcutaneous nerve stimulation
1) Confidence 0.42 Published 1995 Journal Neuroreport Section Abstract Doc Link 8527736 Disease Relevance 0.17 Pain Relevance 0.70
Both low- and high-frequency TENS inhibited by 100% the hyperalgesia but not the edema response.
Negative_regulation (inhibited) of TENS associated with pressure and volume under development and hyperalgesia
2) Confidence 0.38 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15541425 Disease Relevance 0.95 Pain Relevance 0.61
Cholecystokinin receptors mediate tolerance to the analgesic effect of TENS in arthritic rats.
Negative_regulation (effect) of TENS associated with analgesic, tolerance, cholecystokinin and arthritis
3) Confidence 0.35 Published 2010 Journal Pain Section Title Doc Link 19944533 Disease Relevance 0.42 Pain Relevance 1.97
However, the clinical effectiveness of TENS is controversial, with some studies supporting and others refuting its clinical use [11,16].
Negative_regulation (effectiveness) of TENS associated with transcutaneous nerve stimulation
4) Confidence 0.16 Published 2007 Journal BMC Anesthesiol Section Body Doc Link PMC1887521 Disease Relevance 0.95 Pain Relevance 1.59

General Comments

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