INT6073

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Context Info
Confidence 0.59
First Reported 1981
Last Reported 2008
Negated 4
Speculated 1
Reported most in Abstract
Documents 63
Total Number 64
Disease Relevance 8.67
Pain Relevance 53.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk)
Anatomy Link Frequency
spinal cord 10
brain 10
spinal 8
nucleus 4
pancreas 4
Penk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 355 100.00 Very High Very High Very High
Opioid 66 100.00 Very High Very High Very High
narcan 63 100.00 Very High Very High Very High
Dynorphin 47 100.00 Very High Very High Very High
antinociception 34 100.00 Very High Very High Very High
medulla 22 100.00 Very High Very High Very High
tail-flick 21 100.00 Very High Very High Very High
Somatostatin 15 100.00 Very High Very High Very High
amygdala 11 100.00 Very High Very High Very High
substance P 4 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 9 100.00 Very High Very High Very High
Hepatic Encephalopathy 10 99.52 Very High Very High Very High
Hypotension 8 99.52 Very High Very High Very High
Necrosis 12 99.32 Very High Very High Very High
Arthritis 6 99.16 Very High Very High Very High
Cancer 12 99.14 Very High Very High Very High
Hypoxia 9 98.28 Very High Very High Very High
Injury 5 95.88 Very High Very High Very High
Sprains And Strains 2 95.44 Very High Very High Very High
Pain 6 95.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro superfusion of GABA (100 microM) produced a approximately equal to 63% decrease in IR-Met-enkephalin released from striatal slices in both saline and acute PTZ-treated rats.
Negative_regulation (decrease) of Localization (released) of enkephalin associated with gaba and enkephalin
1) Confidence 0.59 Published 1985 Journal Brain Res. Section Abstract Doc Link 4075166 Disease Relevance 0.24 Pain Relevance 0.86
Increased GABA-mediated neurotransmission, reported to occur in hepatic encephalopathy (HE), is associated with a decrease in the release of Met-enkephalin and the expression of its coding gene in the brain.
Negative_regulation (decrease) of Localization (release) of Met-enkephalin in brain associated with gaba, hepatic encephalopathy and enkephalin
2) Confidence 0.59 Published 2002 Journal Life Sci. Section Abstract Doc Link 11991257 Disease Relevance 0.73 Pain Relevance 0.59
CRF, however, failed to modify beta-END and DYN release in hypothalami of FA-treated rats, whereas ENK release was markedly reduced.
Neg (failed) Negative_regulation (reduced) of Localization (release) of ENK associated with dynorphin and enkephalin
3) Confidence 0.58 Published 1991 Journal Brain Res. Section Abstract Doc Link 1686211 Disease Relevance 0.33 Pain Relevance 1.13
In response to CRF (10(-10) M) the release of both Met-enkephalin and dynorphin were significantly diminished in slices of 6-OHDA-lesioned striata.
Negative_regulation (diminished) of Localization (release) of Met-enkephalin associated with dynorphin and enkephalin
4) Confidence 0.57 Published 1990 Journal Brain Res. Section Abstract Doc Link 1981853 Disease Relevance 0 Pain Relevance 0.95
Similarly, a high concentration (5 microM) of SNC80 suppressed enkephalin release.
Negative_regulation (suppressed) of Localization (release) of enkephalin associated with enkephalin
5) Confidence 0.57 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9618438 Disease Relevance 0 Pain Relevance 1.40
High concentrations of morphine (100 nM to 100 microM) had little or no effect, whereas M6G (10 microM) suppressed enkephalin release, an effect that was reversed by beta-FNA.
Negative_regulation (suppressed) of Localization (release) of enkephalin associated with enkephalin and morphine
6) Confidence 0.57 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9618438 Disease Relevance 0 Pain Relevance 1.43
The impairment may be ascribed to the diminished enkephalin release detected in rat striatum after chronic ethanol consumption.
Negative_regulation (diminished) of Localization (release) of enkephalin in striatum associated with enkephalin
7) Confidence 0.57 Published 1984 Journal Brain Res. Section Abstract Doc Link 6320974 Disease Relevance 0 Pain Relevance 0.57
The release of immunoreactive Met-enkephalin was not blocked by the pretreatment with 5 mg/kg naloxone, i.p.
Negative_regulation (blocked) of Localization (release) of Met-enkephalin associated with narcan and enkephalin
8) Confidence 0.56 Published 1985 Journal Brain Res. Section Abstract Doc Link 2864105 Disease Relevance 0 Pain Relevance 1.33
Naloxone treatment inhibited the spontaneous fall of adrenal ENK release during the hypotensive phase; the ENK values remained elevated 20- to 35-fold.
Negative_regulation (inhibited) of Localization (release) of ENK associated with hypotension and narcan
9) Confidence 0.55 Published 1984 Journal Res Exp Med (Berl) Section Abstract Doc Link 6089283 Disease Relevance 0.57 Pain Relevance 0.61
Atropine, yohimbine but not naloxone significantly (p < 0.05) inhibited Leu-Enk-evoked glucagon release from normal rat pancreas.
Negative_regulation (inhibited) of Localization (release) of Leu-Enk-evoked in pancreas associated with narcan
10) Confidence 0.55 Published 2001 Journal Arch. Physiol. Biochem. Section Abstract Doc Link 11880925 Disease Relevance 0.30 Pain Relevance 0.30
Such in vivo and in vitro findings suggest that the GABA-induced inhibition of Met-enkephalin release took place via the stimulation of specific GABA A and GABA B receptors within the caudate nucleus, whereas the GABA-induced increase of the peptide release might involve some intracellular regulatory processes in striatal neurones containing both GABA and enkephalins.
Negative_regulation (inhibition) of Localization (release) of Met-enkephalin in caudate nucleus associated with gaba and enkephalin
11) Confidence 0.52 Published 1985 Journal Brain Res. Section Abstract Doc Link 3936593 Disease Relevance 0 Pain Relevance 1.30
One week after denervation which inhibits release of leucine-enkephalin (L-ENK), but not synthesis and processing of the L-ENK precursor, L-ENK increased with the same relative extent in both strains of rats, starting from a lower basal concentration in 7 weeks old SHRSP.
Negative_regulation (inhibits) of Localization (release) of L-ENK associated with enkephalin and sprains and strains
12) Confidence 0.51 Published 1984 Journal Clin Exp Hypertens A Section Abstract Doc Link 6532590 Disease Relevance 0.17 Pain Relevance 0.31
Several organic calcium antagonists, including nimodipine, nifedipine, nicardipine, gallopamil and flunarizine, are able to inhibit the potassium-evoked met-enkephalin release both in vitro and ex vivo.
Negative_regulation (inhibit) of Localization (release) of met-enkephalin associated with antagonist and enkephalin
13) Confidence 0.51 Published 1990 Journal J. Neural Transm. Gen. Sect. Section Abstract Doc Link 1689585 Disease Relevance 0 Pain Relevance 0.58
In addition, in each of the two brain sites, the release of both Met-enkephalin and dynorphin in response to CRF (10(-8) M) was completely blocked by alpha-helical CRF9-41 (10(-6) M).
Negative_regulation (blocked) of Localization (release) of Met-enkephalin in brain associated with dynorphin and enkephalin
14) Confidence 0.49 Published 1989 Journal Brain Res. Section Abstract Doc Link 2569903 Disease Relevance 0 Pain Relevance 1.34
Chronic treatment with lithium in vivo (10 days) had no effect on the basal release or hypothalamic content of any of the opioids, but prevented the naloxone-stimulated release of dynorphin and Met-enkephalin in vitro.
Negative_regulation (prevented) of Localization (release) of Met-enkephalin associated with dynorphin, narcan, enkephalin and opioid
15) Confidence 0.45 Published 1990 Journal Neuroscience Section Abstract Doc Link 2172862 Disease Relevance 0.09 Pain Relevance 1.61
A topical application of dibucaine abolished the formalin-induced increase in the release of immunoreactive Met-enkephalin.
Negative_regulation (abolished) of Localization (release) of Met-enkephalin associated with enkephalin
16) Confidence 0.43 Published 1984 Journal Brain Res. Bull. Section Abstract Doc Link 6713210 Disease Relevance 0 Pain Relevance 0.50
One week after denervation which inhibits release of leucine-enkephalin (L-ENK), but not synthesis and processing of the L-ENK precursor, L-ENK increased with the same relative extent in both strains of rats, starting from a lower basal concentration in 7 weeks old SHRSP.
Negative_regulation (inhibits) of Localization (release) of leucine-enkephalin associated with enkephalin and sprains and strains
17) Confidence 0.43 Published 1984 Journal Clin Exp Hypertens A Section Abstract Doc Link 6532590 Disease Relevance 0.17 Pain Relevance 0.31
This study describes the ultrastructural localization of the opioid peptide enkephalin (ENK) in the preoptic nucleus of the goldfish.
Negative_regulation (describes) of Localization (localization) of opioid peptide enkephalin in nucleus associated with enkephalin and opioid
18) Confidence 0.43 Published 1981 Journal Neurosci. Lett. Section Abstract Doc Link 6173823 Disease Relevance 0 Pain Relevance 0.62
This study describes the ultrastructural localization of the opioid peptide enkephalin (ENK) in the preoptic nucleus of the goldfish.
Negative_regulation (describes) of Localization (localization) of ENK in nucleus associated with enkephalin and opioid
19) Confidence 0.43 Published 1981 Journal Neurosci. Lett. Section Abstract Doc Link 6173823 Disease Relevance 0 Pain Relevance 0.62
Treatment of the cultures with the cytotoxic agent, cytosine arabinoside, attenuated this temporal increase of ECP secretion, whilst leaving the stimulated release of free met-enkephalin relatively unaffected.
Neg (unaffected) Negative_regulation (unaffected) of Localization (release) of met-enkephalin associated with enkephalin
20) Confidence 0.43 Published 1993 Journal Neuroendocrinology Section Abstract Doc Link 8413825 Disease Relevance 0 Pain Relevance 0.80

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