INT60741

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Context Info
Confidence 0.16
First Reported 1994
Last Reported 2011
Negated 0
Speculated 3
Reported most in Body
Documents 9
Total Number 12
Disease Relevance 6.98
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
macrophages 4
T-cell 4
NK cells 2
IFNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 184 100.00 Very High Very High Very High
aspirin 3 83.52 Quite High
agonist 1 83.04 Quite High
Inflammation 90 80.56 Quite High
cINOD 6 75.00 Quite High
corticosteroid 2 73.40 Quite High
withdrawal 2 72.64 Quite High
dexamethasone 1 72.52 Quite High
Opioid 1 69.60 Quite High
antagonist 4 66.64 Quite High
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 72 99.54 Very High Very High Very High
Disease 302 98.76 Very High Very High Very High
Cancer 233 96.92 Very High Very High Very High
Necrosis 22 96.68 Very High Very High Very High
Toxicity 36 96.20 Very High Very High Very High
Lymphangitis 3 94.40 High High
Infection 241 91.84 High High
Cold Sores 214 91.44 High High
Parkinson's Disease 20 86.48 High High
Apoptosis 75 82.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These studies support the view that ACTH released from the pituitary gland is involved in the up-regulation of IFN-alpha, which in turn stimulates the NK cells in the spleen.
Regulation (involved) of Positive_regulation (up-regulation) of IFN-alpha in NK cells
1) Confidence 0.16 Published 1994 Journal Neuroimmunomodulation Section Abstract Doc Link 8528888 Disease Relevance 0 Pain Relevance 0.14
Interestingly, DC from HCV-infected patients are unresponsive to exogenous IFN-?
Regulation (unresponsive) of Positive_regulation (exogenous) of IFN associated with hepatitis c virus infection
2) Confidence 0.14 Published 2010 Journal J Transl Med Section Body Doc Link PMC2991329 Disease Relevance 1.22 Pain Relevance 0.12
In this study, we combined several agents and examined their suppressive effects on the combined lipopolysaccharide (LPS)- and interferon(IFN)-gamma-induced formation of proinflammatory mediators, including prostaglandin (PG) E2 and tumor necrosis factor (TNF)-alpha, in RAW264.7 murine macrophages.
Spec (examined) Regulation (effects) of Positive_regulation (-gamma-induced) of interferon in macrophages associated with necrosis and cancer
3) Confidence 0.10 Published 2003 Journal Biosci. Biotechnol. Biochem. Section Abstract Doc Link 12834283 Disease Relevance 0.51 Pain Relevance 0.12
In this study, we combined several agents and examined their suppressive effects on the combined lipopolysaccharide (LPS)- and interferon(IFN)-gamma-induced formation of proinflammatory mediators, including prostaglandin (PG) E2 and tumor necrosis factor (TNF)-alpha, in RAW264.7 murine macrophages.
Spec (examined) Regulation (effects) of Positive_regulation (-gamma-induced) of IFN in macrophages associated with necrosis and cancer
4) Confidence 0.10 Published 2003 Journal Biosci. Biotechnol. Biochem. Section Abstract Doc Link 12834283 Disease Relevance 0.51 Pain Relevance 0.12
Taken together these results confirm the importance of IFN?
Regulation (confirm) of Positive_regulation (importance) of IFN
5) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.19 Pain Relevance 0
For calculation of the IFN/STAT1 pathway expression score (ES) we used the equation , where Gi?
Regulation (calculation) of Positive_regulation (/) of IFN
6) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0 Pain Relevance 0
In addition, levels of serum and CSF neopterin, a pteridine marker of IFN-?
Regulation (serum) of Positive_regulation (marker) of IFN
7) Confidence 0.05 Published 2011 Journal Parkinson's Disease Section Body Doc Link PMC3018622 Disease Relevance 1.35 Pain Relevance 0.09
The main end-point of this study is to investigate whether the increase of dose intensity, and the related increase in IFN concentration, obtained by the exclusive intravenous administration of IFN?
Spec (whether) Regulation (obtained) of Spec (whether) Positive_regulation (administration) of IFN
8) Confidence 0.05 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1421423 Disease Relevance 0.76 Pain Relevance 0.10
Among other transcription factors involved in induction of the various IFN-?
Regulation (involved) of Positive_regulation (induction) of IFN
9) Confidence 0.03 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.58 Pain Relevance 0
Therefore, this opposite correlation arises due to a parallel increase in both IFN-?
Regulation (arises) of Positive_regulation (increase) of IFN
10) Confidence 0.02 Published 2007 Journal Malar J Section Body Doc Link PMC1781948 Disease Relevance 0.47 Pain Relevance 0.08
Imiqui-mod has indirect effects on T-cells and T-cell cytokines (eg, IL-2, IL-4, IL-5) by the induction of IFN-?
Regulation (effects) of Positive_regulation (induction) of IFN in T-cell associated with cytokine
11) Confidence 0.02 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621408 Disease Relevance 0.69 Pain Relevance 0.24
Imiqui-mod has indirect effects on T-cells and T-cell cytokines (eg, IL-2, IL-4, IL-5) by the induction of IFN-?
Regulation (effects) of in T-cells Positive_regulation (induction) of IFN in T-cell associated with cytokine
12) Confidence 0.01 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621408 Disease Relevance 0.69 Pain Relevance 0.24

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