INT60749

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Context Info
Confidence 0.78
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 12.57
Pain Relevance 1.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IAPP) extracellular region (IAPP) cell-cell signaling (IAPP)
Anatomy Link Frequency
pancreas 3
beta cell 3
urinary bladder 1
blood 1
B-cells 1
IAPP (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 1 100.00 Very High Very High Very High
Cholecystokinin 1 100.00 Very High Very High Very High
Neuropeptide 11 99.80 Very High Very High Very High
Calcitonin gene-related peptide 11 97.40 Very High Very High Very High
Inflammation 61 95.16 Very High Very High Very High
abdominal pain 4 90.52 High High
Migraine 1 81.76 Quite High
Nucleus accumbens 12 78.08 Quite High
aspirin 8 75.00 Quite High
cINOD 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 697 100.00 Very High Very High Very High
Alzheimer's Dementia 37 100.00 Very High Very High Very High
Critical Illness 23 99.84 Very High Very High Very High
Toxicity 50 98.92 Very High Very High Very High
Disease 49 97.52 Very High Very High Very High
INFLAMMATION 68 95.16 Very High Very High Very High
Aging 20 93.20 High High
Stress 139 92.76 High High
Vomiting 155 92.44 High High
Sleep Disorders 6 90.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Centrally and /or peripherally injected neuropeptides, such as amylin, adrenomedullin, bombesin, cholecystokinin, neurotensin, opioid peptides, thyreotropin releasing hormone and vasoactive intestinal peptide, influence both the acid secretion and the gastric mucosal lesions induced by different ulcerogens.
Localization (secretion) of amylin associated with neuropeptide, opioid and cholecystokinin
1) Confidence 0.78 Published 2004 Journal Curr Top Med Chem Section Abstract Doc Link 14754377 Disease Relevance 0.16 Pain Relevance 0.61
Islet amyloid polypeptide (amylin), cosecreted with insulin by the pancreatic beta-cells, has an important role in the regulation of islet cell hormone homeoastasis.
Localization (cosecreted) of amylin) associated with alzheimer's dementia
2) Confidence 0.68 Published 2003 Journal Exp. Clin. Endocrinol. Diabetes Section Abstract Doc Link 12605343 Disease Relevance 0.67 Pain Relevance 0.11
Thus the bladder may not always behave like a passive elastic structure, leading to inaccurate estimation of IAP.
Localization (estimation) of IAP in bladder
3) Confidence 0.64 Published 2007 Journal Crit Care Section Body Doc Link PMC2206509 Disease Relevance 0.20 Pain Relevance 0
Islet amyloid polypeptide (amylin), cosecreted with insulin by the pancreatic beta-cells, has an important role in the regulation of islet cell hormone homeoastasis.
Localization (cosecreted) of Islet amyloid polypeptide associated with alzheimer's dementia
4) Confidence 0.62 Published 2003 Journal Exp. Clin. Endocrinol. Diabetes Section Abstract Doc Link 12605343 Disease Relevance 0.67 Pain Relevance 0.11
Bedside measurement of IAP has been accomplished by transduction of pressures from indwelling femoral vein, rectal, gastric and urinary bladder catheters.
Localization (measurement) of IAP in urinary bladder
5) Confidence 0.48 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2992055 Disease Relevance 0.35 Pain Relevance 0
On the other hand, release of IAP may increase splanchnic blood flow at lower pressures [22].
Localization (release) of IAP in blood
6) Confidence 0.47 Published 2008 Journal Crit Care Section Body Doc Link PMC2374626 Disease Relevance 0.11 Pain Relevance 0
CGRP is a 37-amino acid neuropeptide, primarily released from sensory nerves, whilst AM is produced by stimulated vascular cells, and amylin is secreted from the pancreas.
Localization (secreted) of amylin in pancreas associated with neuropeptide and calcitonin gene-related peptide
7) Confidence 0.46 Published 2004 Journal Physiol. Rev. Section Abstract Doc Link 15269340 Disease Relevance 0.16 Pain Relevance 0.39
In the patients with type 2 diabetes who did not reach normoglycemia on a combination therapy of sulfonylurea and metformin, adjunctive exenatide or insulin glargine each reduced A1C by 1.1%, with about 46% of patients on each therapy achieving A1C ?
Localization (type) of diabetes associated with diabetes mellitus
8) Confidence 0.45 Published 2008 Journal Osteopath Med Prim Care Section Body Doc Link PMC2276216 Disease Relevance 0.39 Pain Relevance 0
An analog of amylin, a pancreatic peptide secreted by ?
Localization (secreted) of amylin
9) Confidence 0.42 Published 2008 Journal Osteopath Med Prim Care Section Body Doc Link PMC2276216 Disease Relevance 0.99 Pain Relevance 0.09
Amylin, also termed islet amyloid polypeptide (IAPP) is a 37 amino acid polypeptide co-synthesized, co-packaged, and co-secreted by the islet beta cell with insulin.
Localization (secreted) of IAPP in beta cell associated with alzheimer's dementia
10) Confidence 0.37 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 1.52 Pain Relevance 0.09
Islet amyloid is formed from the islet amyloid polypeptide (IAPP), a normal constituent of B-cells, co-secreted with insulin.
Localization (secreted) of IAPP in B-cells associated with alzheimer's dementia
11) Confidence 0.35 Published 1995 Journal Diabetes Res. Clin. Pract. Section Abstract Doc Link 8529518 Disease Relevance 2.18 Pain Relevance 0.11
Amylin, also termed islet amyloid polypeptide (IAPP) is a 37 amino acid polypeptide co-synthesized, co-packaged, and co-secreted by the islet beta cell with insulin.
Localization (secreted) of amyloid polypeptide in beta cell associated with alzheimer's dementia
12) Confidence 0.33 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 1.53 Pain Relevance 0.09
It may be speculated that enteral feeding itself produces an increase in IAP in critically ill patients, but we did not observe such an association in a preliminary study [32].
Localization (increase) of IAP associated with critical illness
13) Confidence 0.11 Published 2008 Journal Crit Care Section Body Doc Link PMC2575570 Disease Relevance 0.57 Pain Relevance 0
This means that at similar levels of glucose, less amylin is secreted in patients with type 2 diabetes compared with subjects without diabetes (Koda et al 1992).
Localization (secreted) of amylin associated with diabetes mellitus
14) Confidence 0.05 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761191 Disease Relevance 0.65 Pain Relevance 0.08
Amylin is a 37 amino acid peptide neurohormone that is cosecreted from the beta cells of the pancreas along with insulin in response to meals (Cooper et al 1987; Koda et al 1992).
Localization (cosecreted) of Amylin in beta cells
15) Confidence 0.05 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761191 Disease Relevance 0.80 Pain Relevance 0
Amylin is a neurohormone that is cosecreted with insulin from the beta cells of the pancreas, and its concentrations are abnormally low in patients with diabetes (Koda et al 1992).
Localization (cosecreted) of Amylin in pancreas associated with diabetes mellitus
16) Confidence 0.04 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761191 Disease Relevance 1.28 Pain Relevance 0
Amylin is a 37 amino acid peptide neurohormone cosecreted from the beta cells of the pancreas, along with insulin, in response to meals.
Localization (cosecreted) of Amylin in pancreas
17) Confidence 0.04 Published 2008 Journal Drug design, development and therapy Section Abstract Doc Link PMC2761191 Disease Relevance 0.31 Pain Relevance 0

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