INT60750

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Context Info
Confidence 0.65
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 8.29
Pain Relevance 2.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (HNF4A) nucleoplasm (HNF4A) nucleus (HNF4A)
DNA binding (HNF4A) cytoplasm (HNF4A)
Anatomy Link Frequency
colon 3
B-cell 1
adipose tissue 1
A549 1
small intestine 1
HNF4A (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 21 99.20 Very High Very High Very High
antagonist 25 98.70 Very High Very High Very High
diclofenac 7 98.56 Very High Very High Very High
cINOD 44 97.70 Very High Very High Very High
Chronic pancreatitis 2 81.12 Quite High
local anesthetic 2 79.76 Quite High
fibrosis 3 68.96 Quite High
Crohn's disease 160 63.80 Quite High
Inflammation 40 56.48 Quite High
ischemia 4 50.40 Quite High
Disease Link Frequency Relevance Heat
Repression 5 100.00 Very High Very High Very High
Colon Cancer 102 99.84 Very High Very High Very High
Amyloidosis 1 98.32 Very High Very High Very High
Alzheimer's Dementia 7 98.16 Very High Very High Very High
Obesity 81 98.10 Very High Very High Very High
Lung Cancer 18 95.48 Very High Very High Very High
Diabetes Mellitus 26 95.32 Very High Very High Very High
Colorectal Cancer 54 90.40 High High
INFLAMMATION 44 90.32 High High
Familial Adenomatous Polyposis 27 87.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A mutation of the glucokinase gene in MODY leads to diminished B-cell secretion but not amyloid formation.
Gene_expression (mutation) of MODY in B-cell associated with alzheimer's dementia
1) Confidence 0.65 Published 1995 Journal Diabetes Res. Clin. Pract. Section Abstract Doc Link 8529518 Disease Relevance 2.64 Pain Relevance 0.19
We show that the NSAID diclofenac inhibits Wnt/beta-catenin signaling without altering the level of beta-catenin protein and reduces the expression of beta-catenin/TCF-dependent genes.
Gene_expression (expression) of TCF associated with cinod and diclofenac
2) Confidence 0.58 Published 2005 Journal FEBS Lett. Section Abstract Doc Link 16051228 Disease Relevance 0.35 Pain Relevance 0.45
This implicates that, in addition to liver, HNF4-alpha could be an important regulator of gene expression and energy metabolism in adipose tissue, at least in lean subjects.Fig. 5Network of direct interactions between transcription factors HNF4alpha, SREBP1 and PPARA and genes involved in energy metabolism that were differentially expressed in lean subjects in response to intervention spread compared to control spread.
Gene_expression (expressed) of HNF4alpha in adipose tissue associated with obesity
3) Confidence 0.58 Published 2008 Journal Genes Nutr Section Body Doc Link PMC2593008 Disease Relevance 0.28 Pain Relevance 0.06
-catenin/Tcf signaling in colon cancer cells by disrupting nuclear ?
Gene_expression (signaling) of Tcf in colon associated with colon cancer
4) Confidence 0.09 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.60 Pain Relevance 0.41
-catenin/Tcf signaling in colon cancer cells by disrupting nuclear ?
Gene_expression (/) of Tcf in colon associated with colon cancer
5) Confidence 0.09 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.60 Pain Relevance 0.41
-catenin/Tcf-responsive genes by modulating Tcf activity without disrupting ?
Gene_expression (/) of Tcf
6) Confidence 0.09 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.99 Pain Relevance 0.56
Using site-directed mutagenesis and the ChIP assay, we were able to define two functional TCF binding sites on the PLD2 promoter, suggesting that the PLD2 gene is a direct transcriptional target of ?
Gene_expression (sites) of TCF
7) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.37 Pain Relevance 0
Moreover, we found that TCF binding sites on the PLD2 promoter are conserved across species (Figure 4F).
Gene_expression (sites) of TCF
8) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.05 Pain Relevance 0
In this study, we demonstrate promoter demethylation of WIF-1; restoration of WIF-1 expression, and underexpression of cytosolic beta-catenin protein and TCF reporter activity, after procaine and procainamide treatment in H460 and A549 cell lines.
Gene_expression (underexpression) of TCF reporter in A549
9) Confidence 0.05 Published 2009 Journal Oncol. Rep. Section Abstract Doc Link 19885602 Disease Relevance 0.41 Pain Relevance 0.08
Kuhnert et al. [35] injected an adenovirus expressing Dick-kopf-1 (Dkk1), a soluble Wnt antagonist, into adult mice and were able to demonstrate an extensive Dkk1 repression of the TCF/LEF target genes and ablated epithelial proliferation in small intestine and colon accompanied with progressive architectural degeneration with loss of crypts, villi, and glandular structure to the extent of mucosal ulceration and lethality.
Gene_expression (repression) of TCF in colon associated with antagonist and repression
10) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2708910 Disease Relevance 0.80 Pain Relevance 0.22
For example, ZNF228 (ENSP00000346305) a Kruppel-like C2H2 zinc finger transcription factor expressed mainly in heart and haematopoietic tissue has a low (<1) dN/dS ratio with chimpanzee, but harbours three SNPs in the DNA binding domain.
Gene_expression (expressed) of transcription in heart
11) Confidence 0.03 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2587479 Disease Relevance 0 Pain Relevance 0
In this study, we demonstrate promoter demethylation of WIF-1; restoration of WIF-1 expression, and underexpression of cytosolic beta-catenin protein and TCF reporter activity, after procaine and procainamide treatment in H460 and A549 cell lines.
Gene_expression (underexpression) of TCF reporter in H460
12) Confidence 0.02 Published 2009 Journal Oncol. Rep. Section Abstract Doc Link 19885602 Disease Relevance 0.41 Pain Relevance 0.08
Kuhnert et al. [35] injected an adenovirus expressing Dick-kopf-1 (Dkk1), a soluble Wnt antagonist, into adult mice and were able to demonstrate an extensive Dkk1 repression of the TCF/LEF target genes and ablated epithelial proliferation in small intestine and colon accompanied with progressive architectural degeneration with loss of crypts, villi, and glandular structure to the extent of mucosal ulceration and lethality.
Gene_expression (repression) of TCF in small intestine associated with antagonist and repression
13) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2708910 Disease Relevance 0.80 Pain Relevance 0.22

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