INT60751

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Context Info
Confidence 0.49
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.50
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (HNF4A) nucleoplasm (HNF4A) nucleus (HNF4A)
DNA binding (HNF4A) cytoplasm (HNF4A)
Anatomy Link Frequency
B-cell 2
HNF4A (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 2 81.60 Quite High
fibrosis 1 69.44 Quite High
metalloproteinase 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 7 98.40 Very High Very High Very High
Amyloidosis 1 98.32 Very High Very High Very High
Obesity 1 95.76 Very High Very High Very High
Diabetes Mellitus 20 95.32 Very High Very High Very High
Disease 2 83.96 Quite High
Pancreatitis 2 81.60 Quite High
Cancer 48 77.96 Quite High
Necrosis 1 74.96 Quite High
Cystic Fibrosis 1 70.00 Quite High
Colon Cancer 66 67.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A mutation of the glucokinase gene in MODY leads to diminished B-cell secretion but not amyloid formation.
Positive_regulation (leads) of Gene_expression (mutation) of MODY in B-cell associated with alzheimer's dementia
1) Confidence 0.49 Published 1995 Journal Diabetes Res. Clin. Pract. Section Abstract Doc Link 8529518 Disease Relevance 2.65 Pain Relevance 0.19
Using site-directed mutagenesis and the ChIP assay, we were able to define two functional TCF binding sites on the PLD2 promoter, suggesting that the PLD2 gene is a direct transcriptional target of ?
Positive_regulation (functional) of Gene_expression (sites) of TCF
2) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.42 Pain Relevance 0
Using site-directed mutagenesis and the ChIP assay, we were able to define two functional TCF binding sites on the PLD2 promoter, suggesting that the PLD2 gene is a direct transcriptional target of ?
Positive_regulation (two) of Gene_expression (sites) of TCF
3) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.42 Pain Relevance 0

General Comments

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