INT60758

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Context Info
Confidence 0.20
First Reported 1995
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 4.12
Pain Relevance 4.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkce) Golgi apparatus (Prkce) endoplasmic reticulum (Prkce)
enzyme binding (Prkce) cytoplasm (Prkce) cytosol (Prkce)
Anatomy Link Frequency
myocytes 1
neurons 1
DRG 1
nociceptors 1
Prkce (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hyperalgesia 19 100.00 Very High Very High Very High
Kinase C 14 100.00 Very High Very High Very High
nociceptor 14 99.92 Very High Very High Very High
dorsal root ganglion 16 99.84 Very High Very High Very High
Eae 4 97.72 Very High Very High Very High
Lasting pain 1 96.88 Very High Very High Very High
agonist 13 96.32 Very High Very High Very High
Inflammation 14 94.84 High High
Spinal cord 2 94.44 High High
qutenza 10 94.00 High High
Disease Link Frequency Relevance Heat
Hyperalgesia 20 100.00 Very High Very High Very High
Herpes Simplex Virus 1 99.58 Very High Very High Very High
Ganglion Cysts 18 99.36 Very High Very High Very High
Injury 5 97.72 Very High Very High Very High
Pain 4 96.88 Very High Very High Very High
Nociception 6 96.44 Very High Very High Very High
INFLAMMATION 10 94.84 High High
Neuropathic Pain 4 93.68 High High
Shock 1 82.56 Quite High
Nervous System Injury 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The epsilon-isozyme of protein kinase C (PKCepsilon) and the vanilloid receptor 1 (VR1) are both expressed in dorsal root ganglion (DRG) neurons and are reported to be predominantly and specifically involved in nociceptive function.
Gene_expression (expressed) of PKCepsilon in DRG associated with nociception, ganglion cysts, dorsal root ganglion and kinase c
1) Confidence 0.20 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12694383 Disease Relevance 0.70 Pain Relevance 0.39
A double-labeling study showed that phosphorylation of PKCepsilon was expressed predominantly in VR1 immunoreactivity positive small diameter DRG neurons mediating the nociceptive information from peripheral tissue to spinal cord.
Gene_expression (expressed) of PKCepsilon in neurons associated with nociception, dorsal root ganglion and spinal cord
2) Confidence 0.20 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12694383 Disease Relevance 1.38 Pain Relevance 0.88
Only protein kinase C-delta and protein kinase C-epsilon were expressed in nuclei that have been isolated from control myocytes, suggesting that these two isotypes of the enzyme may be part of the signal transduction pathway involved in the effect elicited by the phorbol ester on opioid gene transcription in isolated nuclei.
Gene_expression (expressed) of C-epsilon in myocytes associated with kinase c and opioid
3) Confidence 0.19 Published 1995 Journal J. Biol. Chem. Section Abstract Doc Link 8530417 Disease Relevance 0 Pain Relevance 0.58
Here, we employ a highly defective herpes simplex virus vector (vHDNP) that expresses dominant negative PKCepsilon (DNPKCepsilon) as a strategy to demonstrate that PKCepsilon is essential for: (i) maintenance of basal phosphorylation and normal TRPV1 responses to capsaicin (CAPS), a TRPV1 agonist and (ii) enhancement of TRPV1 responses by phorbol esters.
Neg (negative) Gene_expression (expresses) of PKCepsilon associated with qutenza, herpes simplex virus and agonist
4) Confidence 0.18 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18973552 Disease Relevance 0.40 Pain Relevance 0.82
We evaluated the signalling pathway by which estrogen acts in peripheral tissue to produce protein kinase Cepsilon (PKCepsilon)-dependent mechanical hyperalgesia.
Gene_expression (produce) of PKCepsilon associated with hyperalgesia
5) Confidence 0.17 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18371086 Disease Relevance 0.17 Pain Relevance 0.36
We evaluated the signalling pathway by which estrogen acts in peripheral tissue to produce protein kinase Cepsilon (PKCepsilon)-dependent mechanical hyperalgesia.
Gene_expression (produce) of protein kinase Cepsilon associated with hyperalgesia
6) Confidence 0.17 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18371086 Disease Relevance 0.17 Pain Relevance 0.36
We evaluated the role of lipoxygenase products of arachidonic acid metabolism in mechanical hyperalgesia induced by epinephrine, an agent that directly sensitizes nociceptors to produce mechanical hyperalgesia via three second messenger signaling pathways, protein kinase A (PKA), protein kinase C epsilon (PKCepsilon), and mitogen activated protein kinase (MAPK).
Gene_expression (produce) of PKCepsilon in nociceptors associated with kinase c, hyperalgesia and nociceptor
7) Confidence 0.08 Published 2003 Journal Exp Brain Res Section Abstract Doc Link 12582831 Disease Relevance 0.55 Pain Relevance 0.64
Moreover, real-time quantitative RT-PCR experiments indicated that CCD-induced increase in protein levels was associated with an up-regulation of annexin A2 and PKCepsilon gene expression.
Gene_expression (expression) of PKCepsilon
8) Confidence 0.06 Published 2008 Journal Exp Brain Res Section Abstract Doc Link 18493752 Disease Relevance 0.73 Pain Relevance 0.55

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