INT60759

Context Info Confidence 0.01 First Reported 1995 Last Reported 1995 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.52

endoplasmic reticulum (Ikbip) plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)

Anatomy Link Frequency myocytes 2 Ikbip (Rattus norvegicus) Oprd1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Kinase C 6 100.00 Opioid 4 100.00 Dynorphin 1 73.12 Kinase C inhibitor 1 61.52 Enkephalin 1 25.00

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The phorbol ester-induced increase in prodynorphin gene transcription was prevented by pretreatment of myocytes or isolated nuclei with staurosporine, suggesting that myocardial opioid gene expression may be regulated by nuclear protein kinase C.

nuclear protein kinase Regulation (regulated) of Gene_expression (expression) of myocardial opioid gene in myocytes associated with kinase c and opioid

1) Confidence 0.01 Published 1995 Journal J. Biol. Chem. Section Abstract Doc Link 8530417 Disease Relevance 0 Pain Relevance 0.52

General Comments

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