INT6076

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Context Info
Confidence 0.31
First Reported 1986
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 3.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pomc, Penk) signal transduction (Pomc) generation of precursor metabolites and energy (Pomc)
extracellular space (Pomc) molecular_function (Pomc) cell-cell signaling (Pomc)
Anatomy Link Frequency
spinal 2
Pomc (Rattus norvegicus)
Penk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 21 100.00 Very High Very High Very High
Spinal cord 6 99.28 Very High Very High Very High
antinociception 12 97.52 Very High Very High Very High
intrathecal 5 92.48 High High
tail-flick 5 89.84 High High
antagonist 1 85.72 High High
analgesia 1 80.24 Quite High
Cholecystokinin 2 75.00 Quite High
opioid receptor 1 64.92 Quite High
Analgesic 3 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The stereoisomer N(omega)-nitro-D-arginine given intrathecally, however, did not inhibit the release of Met-enkephalin induced by intraventricularly administered beta-endorphin. beta-Endorphin (4 microg) given intraventricularly produced antinociception in rats pretreated intrathecally with saline.
Negative_regulation (inhibit) of beta-endorphin Positive_regulation (induced) of Met-enkephalin associated with antinociception and enkephalin
1) Confidence 0.31 Published 1997 Journal Neuroscience Section Abstract Doc Link 9145802 Disease Relevance 0 Pain Relevance 1.52
This release of Met-enkephalin induced by beta-endorphin was significantly reduced by beta-endorphin-(1-27), 60 micrograms, injected intraventricularly.
Negative_regulation (reduced) of beta-endorphin Positive_regulation (induced) of Met-enkephalin associated with enkephalin
2) Confidence 0.25 Published 1986 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 2940195 Disease Relevance 0 Pain Relevance 0.63
CCK8s at concentrations from 1 x 10(-9) to 1 x 10(-6) M added into the spinal perfusate decreased the release of Met-enkephalin induced by beta-endorphin given i.vt. in a dose-dependent manner.
Negative_regulation (decreased) of beta-endorphin Positive_regulation (induced) of Met-enkephalin in spinal associated with enkephalin
3) Confidence 0.23 Published 1992 Journal Neuropeptides Section Abstract Doc Link 1321361 Disease Relevance 0 Pain Relevance 1.00

General Comments

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