INT60766

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Context Info
Confidence 0.77
First Reported 1995
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 10
Total Number 17
Disease Relevance 13.46
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL4A4)
Anatomy Link Frequency
macrophages 3
extracellular matrix 3
lymph node 2
chondrocytes 1
stroma 1
COL4A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 149 100.00 Very High Very High Very High
Snapping jaw 6 98.80 Very High Very High Very High
Chronic pancreatitis 3 94.76 High High
Inflammation 40 82.56 Quite High
ischemia 45 76.60 Quite High
cytokine 21 62.96 Quite High
Osteoarthritis 27 55.04 Quite High
palliative 7 32.40 Quite Low
Neurotransmitter 8 27.92 Quite Low
eye pain 2 17.68 Low Low
Disease Link Frequency Relevance Heat
Prostate Cancer 174 99.84 Very High Very High Very High
Syndrome 9 99.72 Very High Very High Very High
Increased Venous Pressure Under Development 41 99.64 Very High Very High Very High
Cancer 898 99.56 Very High Very High Very High
Temporomandibular Joint Syndrome 6 98.80 Very High Very High Very High
Pancreatic Cancer 5 98.56 Very High Very High Very High
Deafness 6 98.16 Very High Very High Very High
Stomach Cancer 189 97.96 Very High Very High Very High
Metastasis 151 97.94 Very High Very High Very High
Disease 73 97.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The objective of this paper was to study the morphology of the articular disc and analyze the immunohistochemical expression of the marker of type IV collagen in the articular disc of the temporomandibular joint (TMJ) of human fetuses of different gestational ages.
Spec (analyze) Gene_expression (expression) of type IV collagen in articular associated with snapping jaw
1) Confidence 0.77 Published 2008 Journal Ital J Anat Embryol Section Abstract Doc Link 18702236 Disease Relevance 0.54 Pain Relevance 0.45
The main abnormality of this syndrome is deficient synthesis of type IV collagen, which is the main component of basement membranes in the human body.
Gene_expression (synthesis) of type IV collagen in body associated with syndrome
2) Confidence 0.71 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2430706 Disease Relevance 1.56 Pain Relevance 0
Immunohistochemical staining for type IV collagen and laminin in the stroma of human pancreatic cancer.
Gene_expression (staining) of type IV collagen in stroma associated with pancreatic cancer
3) Confidence 0.65 Published 1995 Journal Int. J. Pancreatol. Section Title Doc Link 8530835 Disease Relevance 0.60 Pain Relevance 0.18
The main abnormality is deficient synthesis of type IV collagen, the main component of basement membranes.
Gene_expression (synthesis) of type IV collagen in basement membranes
4) Confidence 0.55 Published 2008 Journal J Med Case Reports Section Abstract Doc Link PMC2430706 Disease Relevance 0.87 Pain Relevance 0
The expression of MMP9, MMP2 and type IV collagen, and macrophages infiltration in each slide were scored as the sum of intensity and positive rate scores.
Gene_expression (expression) of IV collagen in macrophages
5) Confidence 0.32 Published 2010 Journal J Transl Med Section Body Doc Link PMC2965128 Disease Relevance 0.33 Pain Relevance 0
In terms of DFS, the study did not reveal any correlation between DFS with expression levels of MMP9, MMP2, type IV collagen, or MVD.
Gene_expression (expression) of IV collagen
6) Confidence 0.32 Published 2010 Journal J Transl Med Section Body Doc Link PMC2965128 Disease Relevance 0.41 Pain Relevance 0
Serosa invasion, lymph node status, TNM stages, recurrence status and distant metastasis were the variables investigated in this study, all of which were not related to the level of MMP9 and IV collagen, but IV collagen expression was significantly decreased in older patients (P = 0.042).
Gene_expression (expression) of IV collagen in lymph node associated with metastasis and recurrence
7) Confidence 0.32 Published 2010 Journal J Transl Med Section Body Doc Link PMC2965128 Disease Relevance 1.02 Pain Relevance 0
Serosa invasion, lymph node status, TNM stages, recurrence status and distant metastasis were the variables investigated in this study, all of which were not related to the level of MMP9 and IV collagen, but IV collagen expression was significantly decreased in older patients (P = 0.042).
Gene_expression (expression) of IV collagen in lymph node associated with metastasis and recurrence
8) Confidence 0.32 Published 2010 Journal J Transl Med Section Body Doc Link PMC2965128 Disease Relevance 1.02 Pain Relevance 0
In contrast, Linear pattern may relate to the worst prognosis because cancer cells may have already deeply penetrated the ECM in spite of the density of the surrounding type IV collagen, and such cancer may have already become a potentially systemic disease even it is diagnosed as early stage by conventional pathology.
Gene_expression (penetrated) of IV collagen associated with cancer and disease
9) Confidence 0.28 Published 2010 Journal J Transl Med Section Body Doc Link PMC2965128 Disease Relevance 1.20 Pain Relevance 0
As a negative control, primary antibody was replaced with Tris-buffered saline on sections that were proven to be positive for MMP9, MMP2, type IV collagen, macrophages and CD105 in preliminary experiments.


Gene_expression (positive) of IV collagen in macrophages
10) Confidence 0.28 Published 2010 Journal J Transl Med Section Body Doc Link PMC2965128 Disease Relevance 0.13 Pain Relevance 0
Paraffin-embedded tissue sections from 37 GC patients were studied by Streptavidin-Peroxidase (SP) immunohistochemical technique to determine the levels of MMP-2, MMP-9, type IV collagen, macrophages infiltration and microvessel density (MVD).
Spec (determine) Gene_expression (levels) of IV collagen in macrophages associated with metalloproteinase and stomach cancer
11) Confidence 0.25 Published 2010 Journal J Transl Med Section Abstract Doc Link PMC2965128 Disease Relevance 1.11 Pain Relevance 0.31
The marked GS-mediated increase of these proteins in chondrocytes points to an elevation in ECM protein synthesis, which might be also hypothesized by the detected increase in Type IV Collagen (COL6A1, essential for chondrocyte anchoring to the pericellular matrix [49]) synthesis caused by GS.
Gene_expression (synthesis) of Type IV Collagen in chondrocytes
12) Confidence 0.14 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945029 Disease Relevance 0.35 Pain Relevance 0.13
To clarify the development of the subepithelial spaces, the basement membrane, demarcating the lamina propria from the epithelial cells, and the underlying network of myofibroblasts within the villus lamina propria were studied, by staining collagen IV and smooth muscle actin (SMA), respectively [29], [30].
Gene_expression (staining) of collagen IV in smooth muscle
13) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2561292 Disease Relevance 0.14 Pain Relevance 0.07
A variety of markers indicate endothelial dysfunction including: poor EC-dependent vasodilation, increased blood levels of von Willebrand factor (vWF), thrombomodulin, selectin, PAI-1, type IV collagen and t-PA were demonstrated in this patients population (Yaqoob et al 1993; Dosquet et al 1994; Myrup et al 1994; Makimattila et al 1996; Huszka et al 1997; Cosentino and Luscher 1998; Elhadd et al 1998; Malamitsi et al 1998; Huvers et al 1999).
Gene_expression (levels) of type IV collagen in blood associated with increased venous pressure under development
14) Confidence 0.06 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350146 Disease Relevance 1.62 Pain Relevance 0
For example, when prostate cells are transformed with the neu oncogene, collagen IV is overexpressed in PCa cell lines PC-3 and NbE1.4 [30,31]; while laminin alone is up-regulated in NbE1.4 [31] and the calcium-independent intercellular cell adhesion molecule-7 (ICAM-1) is down-regulated in PC-3 cells [30].
Gene_expression (overexpressed) of collagen IV in PC-3 associated with prostate cancer and adhesions
15) Confidence 0.05 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC320496 Disease Relevance 0.99 Pain Relevance 0
The ECM or basement membrane of most epithelial sheets is primarily composed of laminin and collagen type IV (coll IV), as well as other collagen subtypes.
Gene_expression (composed) of collagen type IV in basement membrane
16) Confidence 0.04 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC320496 Disease Relevance 1.04 Pain Relevance 0
Differentiated cells were not able to mineralize the matrix due to the important decreased of TUFT1, COL IV, V, XI, XII, OSF-2 and the modification of the extracellular matrix component after the differentiation (CSPG4, HAPLN1, ECM2, FN1).
Gene_expression (important) of COL IV in extracellular matrix
17) Confidence 0.01 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2358905 Disease Relevance 0.53 Pain Relevance 0

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