INT60768

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Context Info
Confidence 0.48
First Reported 1995
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.50
Pain Relevance 2.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pdc) nucleus (Pdc) cilium (Pdc)
cytoplasm (Pdc)
Anatomy Link Frequency
neurons 1
brain 1
astrocyte 1
Pdc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 3 99.48 Very High Very High Very High
Glutamate 24 99.12 Very High Very High Very High
c fibre 3 98.56 Very High Very High Very High
nMDA receptor antagonist 2 97.96 Very High Very High Very High
Abeta 4 96.36 Very High Very High Very High
wide dynamic range 6 94.28 High High
Pain 2 90.48 High High
tetrodotoxin 2 89.28 High High
Glutamate receptor 2 88.12 High High
anticonvulsant 4 84.48 Quite High
Disease Link Frequency Relevance Heat
Drug Induced Neurotoxicity 18 99.92 Very High Very High Very High
Convulsion 2 91.20 High High
Pain 2 90.48 High High
Toxicity 4 76.92 Quite High
Nociception 2 75.00 Quite High
Facial Pain 2 62.48 Quite High
Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Local bath application of 2.0 mg/ml WIN significantly reduced PDC activity (3+/-1% control, P<0.01), C-fiber evoked activity (58+/-9% control, P<0.01), and Abeta evoked activity (57+/-10% control, P<0.01) in WDR neurons.
Negative_regulation (reduced) of PDC in neurons associated with c fibre, wide dynamic range and abeta
1) Confidence 0.48 Published 2004 Journal Pain Section Abstract Doc Link 14736589 Disease Relevance 0.21 Pain Relevance 1.28
Finally, the neurotoxicity of PDC was blocked by coincubation with glutamate-pyruvate transaminase plus pyruvate to degrade extracellular glutamate.
Negative_regulation (blocked) of PDC associated with glutamate and drug induced neurotoxicity
2) Confidence 0.42 Published 1996 Journal Eur. J. Neurosci. Section Abstract Doc Link 8921275 Disease Relevance 0.65 Pain Relevance 0.57
The neurotoxicity of PDC in both astrocyte-rich and astrocyte-poor cultures was blocked by the NMDA antagonist MK-801, but not by the non-NMDA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX).
Negative_regulation (blocked) of PDC in astrocyte associated with nmda receptor antagonist, drug induced neurotoxicity and antagonist
3) Confidence 0.37 Published 1996 Journal Eur. J. Neurosci. Section Abstract Doc Link 8921275 Disease Relevance 0.46 Pain Relevance 0.49
Mechanistically, this inhibition of DCPIP reduction was found to be due to the ability of Cu(II)2(3,5-DIPS)4 to serve as a catalytic electron acceptor for reduced PHD, which was enhanced by the presence of a large concentration of DCPIP and inhibited by a large concentration of NADPH.
Negative_regulation (reduced) of PHD
4) Confidence 0.34 Published 1995 Journal J. Inorg. Biochem. Section Abstract Doc Link 8530918 Disease Relevance 0 Pain Relevance 0.11
It is concluded that Cu(II)2(3,5-DIPS)4 serves as an electron acceptor in down-regulating PHD reduction of DCPIP and in down-regulating NOS in brain tissue sections.
Negative_regulation (reduction) of PHD in brain
5) Confidence 0.22 Published 1995 Journal J. Inorg. Biochem. Section Abstract Doc Link 8530918 Disease Relevance 0.18 Pain Relevance 0.22

General Comments

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