INT60769

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Context Info
Confidence 0.33
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.20
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pdc) nucleus (Pdc) cilium (Pdc)
cytoplasm (Pdc)
Anatomy Link Frequency
neurons 1
cortex 1
Pdc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
c fibre 3 99.98 Very High Very High Very High
wide dynamic range 6 99.14 Very High Very High Very High
Hippocampus 4 91.32 High High
Abeta 4 90.04 High High
isoflurane 2 88.80 High High
anesthesia 5 88.36 High High
anticonvulsant 2 76.04 Quite High
Analgesic 4 75.40 Quite High
agonist 5 75.00 Quite High
Cannabinoid receptor 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Nociception 2 75.00 Quite High
Facial Pain 2 54.00 Quite High
Convulsion 1 36.24 Quite Low
Pain 1 35.52 Quite Low
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, WDR neurons displayed longer latency, C-fiber mediated post-discharge (PDC) activity after repetitive stimulation.
Positive_regulation (mediated) of PDC in neurons associated with c fibre and wide dynamic range
1) Confidence 0.33 Published 2004 Journal Pain Section Abstract Doc Link 14736589 Disease Relevance 0.20 Pain Relevance 1.19
Mechanistically, this inhibition of DCPIP reduction was found to be due to the ability of Cu(II)2(3,5-DIPS)4 to serve as a catalytic electron acceptor for reduced PHD, which was enhanced by the presence of a large concentration of DCPIP and inhibited by a large concentration of NADPH.
Positive_regulation (enhanced) of PHD
2) Confidence 0.29 Published 1995 Journal J. Inorg. Biochem. Section Abstract Doc Link 8530918 Disease Relevance 0 Pain Relevance 0.11
In this study, a variation of partial directed coherence, the generalized partial directed coherence (gPDC), along with a newly proposed critical value for gPDC, were applied on recorded local field potentials (LFPs) and single-unit activity, in order to assess information flow between medial prefrontal cortex (mPFC) and hippocampus and within the hippocampus of the rat brain, under isoflurane anesthesia and kainic acid-induced enhanced neuronal activity.
Positive_regulation (generalized) of gPDC in cortex associated with anesthesia, isoflurane and hippocampus
3) Confidence 0.10 Published 2010 Journal Biol Cybern Section Abstract Doc Link 20204395 Disease Relevance 0 Pain Relevance 0.40

General Comments

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