INT60772

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Context Info
Confidence 0.41
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 4.56
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Ednrb) aging (Ednrb) plasma membrane (Ednrb)
signal transducer activity (Ednrb)
Anatomy Link Frequency
vasculature 1
renal glomerulus 1
Ednrb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 27 100.00 Very High Very High Very High
Kinase C 35 98.80 Very High Very High Very High
headache 2 86.00 High High
ischemia 23 84.96 Quite High
Calcium channel 4 81.52 Quite High
agonist 14 74.52 Quite High
tetrodotoxin 2 52.24 Quite High
withdrawal 3 47.12 Quite Low
Pain refractory 1 29.12 Quite Low
anesthesia 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 1 99.28 Very High Very High Very High
Pressure And Volume Under Development 24 99.20 Very High Very High Very High
Middle Cerebral Artery Infarction 15 95.04 Very High Very High Very High
Reprotox - General 1 5 95.04 Very High Very High Very High
Intestinal Obstruction 2 94.88 High High
Pulmonary Hypertension 164 93.92 High High
Infarction 11 93.48 High High
Congenital Anomalies 16 92.12 High High
Diabetes Mellitus 29 91.44 High High
Stress 15 88.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is also seen in organ culture, where the upregulation of contractile ETB receptors in MCA is attenuated by both PKC inhibitors and ERK1/2 inhibitors [13,14,29].
Negative_regulation (receptors) of ETB associated with kinase c
1) Confidence 0.41 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1770924 Disease Relevance 0.61 Pain Relevance 0.36
(Figure 1B); consequently, 4 enantiomers that are derived from chiral separation share beneficial effects on the pulmonary hypertension through suppressing the ET receptor.12 Besides, a new endothelin receptor antagonist, CPU0213 (Figure 1C), which suppresses both the ETA and ETB, referred as a nonselective (or dual) endothelin receptor antagonist which is effective in suppressing upregulated ET receptors resulting in relieving pulmonary arterial hypertension and vascular abnormalities in diabetic vasculature.1,13

Vascular abnormalities and oxidative stress

Negative_regulation (suppresses) of ETB in vasculature associated with stress, pulmonary hypertension, pressure and volume under development, diabetes mellitus, congenital anomalies and antagonist
2) Confidence 0.21 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941789 Disease Relevance 1.41 Pain Relevance 0.21
Bosentan (Ro 47-0203) is a competitive antagonist of both ETA and ETB.
Negative_regulation (antagonist) of ETB associated with antagonist
3) Confidence 0.17 Published 2006 Journal World J Emerg Surg Section Body Doc Link PMC1764411 Disease Relevance 1.07 Pain Relevance 0.23
In contrast, the ETB desensitization inhibited the effects of only lower concentrations of ET-1.
Negative_regulation (desensitization) of ETB
4) Confidence 0.10 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8531067 Disease Relevance 0 Pain Relevance 0.33
A potent ETB antagonist, BQ-788, showed similar effects to the ETB desensitization.
Negative_regulation (desensitization) of ETB associated with antagonist
5) Confidence 0.10 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8531067 Disease Relevance 0 Pain Relevance 0.18
Although nNHSR of ET-1 increased significantly after ETB receptor blockade in sham rats, it was completely unchanged in DOCA-salt rats.
Negative_regulation (blockade) of ETB receptor
6) Confidence 0.10 Published 2005 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 15471983 Disease Relevance 0.26 Pain Relevance 0
Malignant prostate cells are notable for the loss of ET-B receptors and increased levels of endothelin-1 [ET-1]; this distortion of the endothelin system may be a significant factor in the progression of prostate cancer.
Negative_regulation (loss) of ET-B associated with malignant neoplastic disease and reprotox - general 1
7) Confidence 0.02 Published 2002 Journal Invest New Drugs Section Abstract Doc Link 12099577 Disease Relevance 0.60 Pain Relevance 0
The cause of this reduced hemoglobin with bosentan is unclear but in part may be related to dilutional effects as a result of fluid retention, in part as a result of the effects of ETB receptor blockade in the renal glomerulus.
Negative_regulation (blockade) of ETB receptor in renal glomerulus associated with pressure and volume under development
8) Confidence 0.02 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350123 Disease Relevance 0.61 Pain Relevance 0.09

General Comments

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