INT60776

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.51
First Reported 1995
Last Reported 2008
Negated 0
Speculated 5
Reported most in Body
Documents 20
Total Number 24
Disease Relevance 16.62
Pain Relevance 5.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (EDNRA) signal transduction (EDNRA) aging (EDNRA)
plasma membrane (EDNRA) signal transducer activity (EDNRA)
Anatomy Link Frequency
plasma 3
blood 1
EDNRA (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 152 100.00 Very High Very High Very High
agonist 28 100.00 Very High Very High Very High
analgesia 8 98.36 Very High Very High Very High
Pain 38 98.12 Very High Very High Very High
bradykinin 17 98.00 Very High Very High Very High
Calcium channel 21 97.76 Very High Very High Very High
Inflammation 20 97.76 Very High Very High Very High
cytokine 8 96.68 Very High Very High Very High
fibrosis 4 96.24 Very High Very High Very High
melanocortin 1 receptor 6 96.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 260 99.92 Very High Very High Very High
Hypoxia 107 99.80 Very High Very High Very High
Cancer 269 99.68 Very High Very High Very High
Glaucoma 202 99.68 Very High Very High Very High
Injury 504 99.62 Very High Very High Very High
Reprotox - General 1 73 99.12 Very High Very High Very High
Immunotherapy Of Cancer 8 99.12 Very High Very High Very High
Rheumatoid Arthritis 8 98.76 Very High Very High Very High
Pain 38 98.12 Very High Very High Very High
Disease 120 97.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Regulation of the endothelin/endothelin receptor system by interleukin-1{beta} in human myometrial cells.
Regulation (Regulation) of endothelin/endothelin
1) Confidence 0.51 Published 2005 Journal Endocrinology Section Title Doc Link 16109787 Disease Relevance 0.15 Pain Relevance 0.16
In order to establish whether this difference in ability to modulate Gq-coupled receptor responses is a consequence of low 5-HT1B receptor density, we have stably transfected CHO-KI cells with the human 5-HT1Dbeta cDNA (the human homologue of the rodent 5-HT1B receptor).
Spec (whether) Regulation (modulate) of Gq-coupled receptor
2) Confidence 0.38 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9652344 Disease Relevance 0.05 Pain Relevance 0.24
Regulation of the endothelin/endothelin receptor system by interleukin-1{beta} in human myometrial cells.
Regulation (Regulation) of endothelin/endothelin
3) Confidence 0.38 Published 2005 Journal Endocrinology Section Title Doc Link 16109787 Disease Relevance 0.15 Pain Relevance 0.16
Targeting endothelin receptor as novel approach in cancer treatment
Regulation (Targeting) of endothelin receptor associated with immunotherapy of cancer
4) Confidence 0.29 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 1.55 Pain Relevance 1.05
These effects depend on the ETAR activation and involve multiple MAPK signal pathways, including p42/44 MAPK, p38 MAPK and the transactivation of EGFR.
Regulation (depend) of ETAR
5) Confidence 0.29 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 0.69 Pain Relevance 0.03
In contrast, late treatment, 2 weeks after initiation of hypoxia, did not affect the established elevation of ET-1 level.


Regulation (affect) of ET associated with hypoxia
6) Confidence 0.22 Published 2008 Journal European Heart Journal Section Body Doc Link PMC2515885 Disease Relevance 0.77 Pain Relevance 0.11
In summary endothelial dysfunction is likely related to glaucoma, but the exact role of mediators such as NO, NOS, ET-1, and ETA/ETB in OAG pathophysiology has yet to be fully appreciated.
Regulation (role) of ETA associated with glaucoma
7) Confidence 0.18 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699797 Disease Relevance 1.67 Pain Relevance 0.18
Several recent studies have shifted the focus from solely examining ET-1 expression to investigating the role of ETA and ETB receptors in ocular blood flow.
Spec (investigating) Regulation (role) of ETA in blood
8) Confidence 0.18 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699797 Disease Relevance 0.73 Pain Relevance 0
Thus, ET-1 acting through the ETAR consistently induced the activity of two families of metastasis-related proteinases, the matrix metalloproteinases (MMPs) and the urokinase type plasminogen activator system at several levels: mRNA transcription, zymogen secretion and pro-enzymes activation.
Regulation (acting) of ETAR associated with metalloproteinase and metastasis
9) Confidence 0.17 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 0.90 Pain Relevance 0.24
These results indicate that impairing COX-1 and -2 and their downstream effect by targeting ETAR can be therapeutically advantageous [26] also in view that elevated COX-2 levels are associated with tumor progression and chemoresistance [24].


Regulation (targeting) of ETAR associated with cancer
10) Confidence 0.17 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 0.78 Pain Relevance 0.04
Role of protein kinases in the ETA receptor-mediated potentiation of TRPV1
Regulation (Role) of ETA receptor
11) Confidence 0.15 Published 2007 Journal Mol Pain Section Body Doc Link PMC2206006 Disease Relevance 0 Pain Relevance 0.12
Ongoing studies in a variety of patient populations will better define the role of ET receptor antagonists in the treatment of men with prostate cancer.
Regulation (role) of ET receptor associated with antagonist and reprotox - general 1
12) Confidence 0.13 Published 2003 Journal Semin. Oncol. Section Abstract Doc Link 14571415 Disease Relevance 1.06 Pain Relevance 0.37
These data indicate the generally important role for PLD2 in the regulation of agonist-dependent and agonist-independent G protein-coupled receptor (GPCR) endocytosis.
Regulation (regulation) of protein-coupled receptor associated with agonist
13) Confidence 0.12 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16539674 Disease Relevance 0 Pain Relevance 0.67
Endothelin receptor antagonists appear to be highly effective in treatment PAH in outpatient settings (Badesch et al 2007).
Regulation (effective) of Endothelin receptor associated with pulmonary hypertension and antagonist
14) Confidence 0.10 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605326 Disease Relevance 1.12 Pain Relevance 0.24
The mechanism of cellular injury in hypoxic/ischemic AKI is not known, but alterations in endothelin or nitric oxide regulation of vascular tone, ATP depletion and alterations in the cytoskeleton, changes in heat shock proteins, initiation of the inflammatory response and the generation of reactive oxygen and nitrogen molecules may each play a role in cell injury [31–48].
Spec (may) Regulation (alterations) of endothelin associated with inflammatory response, hypoxia, shock and injury
15) Confidence 0.04 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 2.21 Pain Relevance 0.05
The mechanism of cellular injury in hypoxic/ischemic AKI is not known, but alterations in endothelin or nitric oxide regulation of vascular tone, ATP depletion and alterations in the cytoskeleton, changes in heat shock proteins, initiation of the inflammatory response and the generation of reactive oxygen and nitrogen molecules may each play a role in cell injury [31–48].
Spec (may) Regulation (regulation) of endothelin associated with inflammatory response, hypoxia, shock and injury
16) Confidence 0.04 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 2.20 Pain Relevance 0.05
Upon these observations we believed that possible reason for higher plasma ET levels of osteoporotic men then the normal men in our study may be because of the lower bioavaliable estrogen concentration of the males in these ages and as a result possible decrease of estrogens effect in down regulation in ET and consequently increase of ET amount and effects.
Regulation (regulation) of ET in plasma
17) Confidence 0.04 Published 2005 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1242236 Disease Relevance 0.27 Pain Relevance 0
Role of G protein-coupled receptor kinases in the homologous desensitization of the human and mouse melanocortin 1 receptors.
Regulation (Role) of protein-coupled receptor
18) Confidence 0.03 Published 2005 Journal Mol. Endocrinol. Section Title Doc Link 15650023 Disease Relevance 0.29 Pain Relevance 0.55
[Roles of endothelin and its receptors in prostate cancer].
Regulation ([Roles) of endothelin associated with reprotox - general 1
19) Confidence 0.02 Published 2006 Journal Zhonghua Nan Ke Xue Section Title Doc Link 16755881 Disease Relevance 0.51 Pain Relevance 0.07
B2R, a member of the G protein-coupled receptor (GPCR) superfamily, is a potential drug target in the treatment of cardiovascular disorders, pain and inflammation.
Regulation (target) of protein-coupled receptor associated with pain and inflammation
20) Confidence 0.02 Published 2006 Journal Biol. Chem. Section Abstract Doc Link 16740128 Disease Relevance 0.20 Pain Relevance 0.34

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox