INT6078

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Context Info
Confidence 0.51
First Reported 1985
Last Reported 1997
Negated 1
Speculated 0
Reported most in Abstract
Documents 13
Total Number 16
Disease Relevance 0
Pain Relevance 15.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pomc, Penk) signal transduction (Pomc) generation of precursor metabolites and energy (Pomc)
extracellular space (Pomc) molecular_function (Pomc) cell-cell signaling (Pomc)
Anatomy Link Frequency
spinal 12
spinal cord 8
tail 2
Pomc (Rattus norvegicus)
Penk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 124 100.00 Very High Very High Very High
antinociception 48 100.00 Very High Very High Very High
Spinal cord 38 99.92 Very High Very High Very High
tail-flick 22 99.64 Very High Very High Very High
intrathecal 24 99.08 Very High Very High Very High
Cholecystokinin 4 99.04 Very High Very High Very High
Pain 2 98.50 Very High Very High Very High
Analgesic 12 98.34 Very High Very High Very High
anesthesia 2 98.28 Very High Very High Very High
nociceptor 2 98.28 Very High Very High Very High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study was designed to determine the role of nitric oxide in the spinal cord on beta-endorphin-induced release of Met-enkephalin and antinociception.
beta-endorphin Positive_regulation (induced) of Localization (release) of Met-enkephalin in spinal cord associated with antinociception, enkephalin and spinal cord
1) Confidence 0.51 Published 1997 Journal Neuroscience Section Abstract Doc Link 9145802 Disease Relevance 0 Pain Relevance 1.18
The effect of intraventricular beta-endorphin-(1-27) on the spinal release of Met-enkephalin induced by intraventricular beta-endorphin was studied using the intrathecal superfusion technique in urethane anesthetized rats.
beta-endorphin Positive_regulation (induced) of Localization (release) of Met-enkephalin in spinal associated with enkephalin and intrathecal
2) Confidence 0.41 Published 1986 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 2940195 Disease Relevance 0 Pain Relevance 0.56
This release of Met-enkephalin induced by beta-endorphin was significantly reduced by beta-endorphin-(1-27), 60 micrograms, injected intraventricularly.
beta-endorphin Positive_regulation (induced) of Localization (release) of Met-enkephalin associated with enkephalin
3) Confidence 0.41 Published 1986 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 2940195 Disease Relevance 0 Pain Relevance 0.62
Effects of bestatin and thiorphan administered intrathecally, on inhibition of the tail-flick response and the release of Met-enkephalin induced by beta-endorphin administered intraventricularly were studied in anesthetized rats.
beta-endorphin Positive_regulation (induced) of Localization (release) of Met-enkephalin in tail associated with tail-flick and enkephalin
4) Confidence 0.37 Published 1990 Journal Neuropeptides Section Abstract Doc Link 2250768 Disease Relevance 0 Pain Relevance 0.52
Inhibition of spinal nitric oxide synthase by N(omega)-nitro-L-arginine blocks the release of Met-enkephalin and antinociception induced by supraspinally administered beta-endorphin in the rat.
beta-endorphin Positive_regulation (induced) of Localization (release) of Met-enkephalin in spinal associated with antinociception, analgesic and enkephalin
5) Confidence 0.37 Published 1997 Journal Neuroscience Section Title Doc Link 9145802 Disease Relevance 0 Pain Relevance 1.59
N(omega)-Nitro-L-arginine (10 microg) given intraventricularly did not affect intraventricularly administered beta-endorphin-induced Met-enkephalin release nor did it affect intraventricular beta-endorphin-induced antinociception, indicating that the effect of N(omega)-nitro-L-arginine is not at supraspinal sites.
beta-endorphin Neg (nor) Positive_regulation (induced) of Localization (release) of Met-enkephalin associated with antinociception and enkephalin
6) Confidence 0.37 Published 1997 Journal Neuroscience Section Abstract Doc Link 9145802 Disease Relevance 0 Pain Relevance 1.30
The stereoisomer N(omega)-nitro-D-arginine given intrathecally, however, did not inhibit the release of Met-enkephalin induced by intraventricularly administered beta-endorphin. beta-Endorphin (4 microg) given intraventricularly produced antinociception in rats pretreated intrathecally with saline.
beta-endorphin Positive_regulation (induced) of Localization (release) of Met-enkephalin associated with antinociception and enkephalin
7) Confidence 0.37 Published 1997 Journal Neuroscience Section Abstract Doc Link 9145802 Disease Relevance 0 Pain Relevance 1.51
Intrathecal administration of thiorphan and bestatin enhances the antinociception and release of Met-enkephalin induced by beta-endorphin intraventricularly in anesthetized rats.
beta-endorphin Positive_regulation (induced) of Localization (release) of Met-enkephalin associated with antinociception, enkephalin and intrathecal
8) Confidence 0.35 Published 1990 Journal Neuropeptides Section Title Doc Link 2250768 Disease Relevance 0 Pain Relevance 0.99
The author has previously reported that i.c.v. beta-endorphin increases the release of immunoreactive Met-enkephalin from the spinal cord.
beta-endorphin Positive_regulation (increases) of Localization (release) of Met-enkephalin in spinal cord associated with enkephalin and spinal cord
9) Confidence 0.34 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3020229 Disease Relevance 0 Pain Relevance 0.73
Intraventricular naloxone, 30 micrograms did not induce any release of immunoreactive met-enkephalin from the spinal cord and did not block the release of immunoreactive met-enkephalin induced by intraventricular beta-endorphin, 15 micrograms.
beta-endorphin Positive_regulation (induced) of Localization (release) of met-enkephalin in spinal cord associated with narcan, enkephalin and spinal cord
10) Confidence 0.31 Published 1986 Journal Regul. Pept. Section Abstract Doc Link 2941824 Disease Relevance 0 Pain Relevance 1.05
CCK8s at concentrations from 1 x 10(-9) to 1 x 10(-6) M added into the spinal perfusate decreased the release of Met-enkephalin induced by beta-endorphin given i.vt. in a dose-dependent manner.
beta-endorphin Positive_regulation (induced) of Localization (release) of Met-enkephalin in spinal associated with enkephalin
11) Confidence 0.27 Published 1992 Journal Neuropeptides Section Abstract Doc Link 1321361 Disease Relevance 0 Pain Relevance 0.99
beta-Endorphin-(1-27) inhibits the spinal beta-endorphin-induced release of Met-enkephalin.
beta-endorphin Positive_regulation (induced) of Localization (release) of Met-enkephalin in spinal associated with enkephalin
12) Confidence 0.26 Published 1986 Journal Int. J. Pept. Protein Res. Section Title Doc Link 2940195 Disease Relevance 0 Pain Relevance 0.61
Intrathecal cholecystokinin octapeptide attenuates the antinociception and release of immunoreactive Met-enkephalin induced by intraventricular beta-endorphin in the rat.
beta-endorphin Positive_regulation (induced) of Localization (release) of Met-enkephalin associated with antinociception, enkephalin, cholecystokinin and intrathecal
13) Confidence 0.25 Published 1992 Journal Neuropeptides Section Title Doc Link 1321361 Disease Relevance 0 Pain Relevance 1.01
The intraventricular beta-endorphin elicited the release of immunoreactive met-enkephalin from the spinal cord in a dose dependent manner.
beta-endorphin Positive_regulation (elicited) of Localization (release) of met-enkephalin in spinal cord associated with enkephalin and spinal cord
14) Confidence 0.25 Published 1986 Journal Regul. Pept. Section Abstract Doc Link 2941824 Disease Relevance 0 Pain Relevance 0.95
Intraventricular beta-endorphin, 16 micrograms, caused a marked spinal release of immunoreactive Met-enkephalin and to a much lesser extent, of immunoreactive Leu-enkephalin while intraventricular morphine, 40 micrograms, did not cause any significant release of immunoreactive enkephalins.
beta-endorphin Positive_regulation (caused) of Localization (release) of Met-enkephalin in spinal associated with enkephalin and morphine
15) Confidence 0.25 Published 1985 Journal Brain Res. Section Abstract Doc Link 2864105 Disease Relevance 0 Pain Relevance 1.22
Lack of inhibitory effect of aprotinin and bacitracin on the spinal release of Met-enkephalin induced by intraventricular beta-endorphin.
beta-endorphin Positive_regulation (induced) of Localization (release) of Met-enkephalin in spinal associated with enkephalin
16) Confidence 0.20 Published 1986 Journal Peptides Section Title Doc Link 2426688 Disease Relevance 0 Pain Relevance 0.63

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