INT60789

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.34
First Reported 1995
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 0.91
Pain Relevance 3.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Chrna9)
Anatomy Link Frequency
brain 3
central nervous system 1
Chrna9 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 16 100.00 Very High Very High Very High
Pain 12 100.00 Very High Very High Very High
Central nervous system 2 100.00 Very High Very High Very High
nociceptor 2 100.00 Very High Very High Very High
agonist 33 98.68 Very High Very High Very High
Dopamine 6 97.96 Very High Very High Very High
Pyramidal cell 1 91.96 High High
imagery 3 91.76 High High
GABAergic 7 88.36 High High
gABA 1 86.96 High High
Disease Link Frequency Relevance Heat
Nociception 1 98.88 Very High Very High Very High
Pain 10 96.48 Very High Very High Very High
Injury 2 95.88 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 12 45.60 Quite Low
Disease 5 42.12 Quite Low
Cognitive Disorder 2 5.00 Very Low Very Low Very Low
Neurological Disease 1 5.00 Very Low Very Low Very Low
Schizophrenia 1 5.00 Very Low Very Low Very Low
Aging 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antagonist of nicotinic acetylcholine receptors (nAChR) enhances formalin-induced nociception in rats: tonic role of nAChRs in the control of pain following injury.
Negative_regulation (Antagonist) of nAChR associated with nociception, pain, antagonist and injury
1) Confidence 0.34 Published 2001 Journal Brain Res. Section Title Doc Link 11146056 Disease Relevance 0.91 Pain Relevance 1.44
Reducing alpha7* nAChR inhibition by endogenous KYNA may be an important determinant of the effectiveness of galantamine in neurological and psychiatric disorders associated with decreased alpha7* nAChR activity in the brain.
Negative_regulation (decreased) of nAChR in brain
2) Confidence 0.26 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17446300 Disease Relevance 0 Pain Relevance 0.19
This effect resulted from alpha7* nAChR inhibition and was blocked by coapplied galantamine (1-5 microM).
Negative_regulation (inhibition) of nAChR
3) Confidence 0.22 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17446300 Disease Relevance 0 Pain Relevance 0.35
Reducing alpha7* nAChR inhibition by endogenous KYNA may be an important determinant of the effectiveness of galantamine in neurological and psychiatric disorders associated with decreased alpha7* nAChR activity in the brain.
Negative_regulation (inhibition) of nAChR in brain
4) Confidence 0.16 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17446300 Disease Relevance 0 Pain Relevance 0.32
Reducing alpha7* nAChR inhibition by endogenous KYNA may be an important determinant of the effectiveness of galantamine in neurological and psychiatric disorders associated with decreased alpha7* nAChR activity in the brain.
Negative_regulation (Reducing) of nAChR in brain
5) Confidence 0.16 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17446300 Disease Relevance 0 Pain Relevance 0.32
Not only do alpha7 nAChRs desensitize faster than alpha4beta2 nAChRs, but also alpha7 nAChR desensitization induced by ACh lasts longer than that induced by choline.
Negative_regulation (desensitization) of nAChR
6) Confidence 0.12 Published 2000 Journal Behav. Brain Res. Section Abstract Doc Link 10942040 Disease Relevance 0 Pain Relevance 0.48
Studies with TMB-8 or BAPTA [1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid] analogues indicate that the amino group of TMB-8 is essential and that Ca2+ chelation is not required for inhibition of nAChR function.
Negative_regulation (inhibition) of nAChR
7) Confidence 0.03 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8531111 Disease Relevance 0 Pain Relevance 0.37
TMB-8 is also a potent inhibitor (IC50 approximately 500 nM) of a functional, central nervous system nAChR subtype that mediates nicotinic agonist-stimulated [3H]dopamine release from rat brain synaptosomes.
Negative_regulation (inhibitor) of nAChR in central nervous system associated with dopamine, agonist and central nervous system
8) Confidence 0.02 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8531111 Disease Relevance 0 Pain Relevance 0.44
Measurement of inositol 1,4,5-trisphosphate in single cells and assessment of mACh receptor desensitization
Negative_regulation (desensitization) of mACh receptor
9) Confidence 0.01 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2658029 Disease Relevance 0 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox