INT608

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 1976
Last Reported 2011
Negated 4
Speculated 4
Reported most in Abstract
Documents 98
Total Number 102
Disease Relevance 72.36
Pain Relevance 31.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (KNG1) extracellular region (KNG1) plasma membrane (KNG1)
Anatomy Link Frequency
lung 6
platelet 3
ileum 2
urine 2
plasma 1
KNG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 549 100.00 Very High Very High Very High
antagonist 108 100.00 Very High Very High Very High
b2 receptor 103 100.00 Very High Very High Very High
cytokine 27 100.00 Very High Very High Very High
Enkephalin 19 100.00 Very High Very High Very High
substance P 19 100.00 Very High Very High Very High
Serotonin 18 100.00 Very High Very High Very High
Neuropeptide 12 100.00 Very High Very High Very High
Cholecystokinin 3 100.00 Very High Very High Very High
Somatostatin 1 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Weight Loss 1318 100.00 Very High Very High Very High
Wheal 13 100.00 Very High Very High Very High
Asthma 2610 99.92 Very High Very High Very High
Pain 398 99.84 Very High Very High Very High
Brain Injury 26 99.84 Very High Very High Very High
Pancreatitis 17 99.84 Very High Very High Very High
INFLAMMATION 318 99.76 Very High Very High Very High
Necrosis 15 99.60 Very High Very High Very High
Natriuresis 4 99.52 Very High Very High Very High
Cancer 117 99.42 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Capsaicin pre-treatment caused significant inhibition of the immediate mean flare responses (95% CI) to both bradykinin (from 51.5 [39.7-63.3] mm2 to 16.2 [8.0-24.5] mm2) (P < 0.01) and histamine (from 108.4 [80.4-136.4] mm2 to 52.3 [37.1-67.1] mm2) (P < 0.01).
Negative_regulation (inhibition) of bradykinin associated with qutenza and bradykinin
1) Confidence 0.43 Published 1992 Journal Clin. Exp. Allergy Section Abstract Doc Link 1464049 Disease Relevance 0.46 Pain Relevance 0.85
This result could not be predicted on the basis of inhibition of bradykinin binding to its guinea-pig ileum receptor or to previous studies of bradykinin-induced pain production in animal models.
Negative_regulation (inhibition) of bradykinin in ileum associated with pain and bradykinin
2) Confidence 0.43 Published 1992 Journal Arch. Dermatol. Res. Section Abstract Doc Link 1554240 Disease Relevance 0.54 Pain Relevance 1.18
Intra-articular morphine resulted in a significant decrease in synovial white blood cell count, prostaglandin E(2) and bradykinin levels and improvement in clinical lameness, kinematic and behavioural parameters, compared to placebo treatment.
Negative_regulation (decrease) of bradykinin in articular
3) Confidence 0.42 Published 2010 Journal Equine Vet. J. Section Body Doc Link 20636777 Disease Relevance 0 Pain Relevance 0
Following transection of the thoracolumbar spinal cord, synchronization failed to develop after hindlimb injections but continued to be seen after forelimb stimulation; similarly, partial denervation of a limb blocked the bradykinin response.
Negative_regulation (blocked) of bradykinin in limb associated with bradykinin and spinal cord
4) Confidence 0.42 Published 1976 Journal Electroencephalogr Clin Neurophysiol Section Abstract Doc Link 58777 Disease Relevance 0 Pain Relevance 0.46
The proteomic profiling of urine samples demonstrated reduced levels of CD59, kininogen-1 and a 39 kDa ITIH4 fragment, as well as the enhanced excretion of a 19 kDa fragment of albumin in patients with ovarian carcinoma compared to control women.
Negative_regulation (reduced) of kininogen-1 in urine associated with ovarian cancer
5) Confidence 0.42 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2998473 Disease Relevance 0.46 Pain Relevance 0
Significant reduced levels of CD59, kininogen-1 and a 39 kDa fragment of inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4), and enhanced excretion of a 19 kDa fragment of albumin, were detected in the urine of patients with ovarian carcinoma compared to the control subjects.
Negative_regulation (reduced) of kininogen-1 in urine associated with ovarian cancer
6) Confidence 0.42 Published 2010 Journal Proteome Sci Section Abstract Doc Link PMC2998473 Disease Relevance 0.52 Pain Relevance 0
The biochemical and pharmacological properties of a novel non-peptide antagonist of the bradykinin (BK) B(1) receptor, SSR240612 [(2R)-2-[((3R)-3-(1,3-benzodioxol-5-yl)-3-[[(6-methoxy-2-naphthyl)sulfonyl]amino]propanoyl)amino]-3-(4-[[2R,6S)-2,6-dimethylpiperidinyl]methyl]phenyl)-N-isopropyl-N-methylpropanamide hydrochloride] were evaluated.
Negative_regulation (antagonist) of bradykinin associated with antagonist and bradykinin
7) Confidence 0.42 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14747609 Disease Relevance 0 Pain Relevance 0.26
The angiotensin-converting enzyme (ACE) is a membrane-bound, zinc metalloendopeptidase involved in the metabolism of many small peptides, particularly in activating angiotensin I to angiotensin II and inactivating bradykinin via the kallikrein-kininogen system.
Negative_regulation (inactivating) of bradykinin associated with bradykinin
8) Confidence 0.42 Published 2010 Journal BMC Cardiovasc Disord Section Body Doc Link PMC3022786 Disease Relevance 0.29 Pain Relevance 0.08
Bradykinin relaxation was nearly completely or completely abolished in endothelium-denuded preparations and, in its place, there was often a small contraction.
Negative_regulation (abolished) of Bradykinin in endothelium associated with bradykinin
9) Confidence 0.42 Published 1994 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 8012902 Disease Relevance 0 Pain Relevance 0.21
The Stewart and Vavrek peptides characterized by a DPhe7 substitution have provided powerful tools for study of bradykinin's actions by competitively and specifically blocking bradykinin B2 receptors.
Negative_regulation (blocking) of bradykinin associated with bradykinin
10) Confidence 0.41 Published 1990 Journal Med Res Rev Section Abstract Doc Link 2158607 Disease Relevance 0.49 Pain Relevance 0.46
A slight yet significant suppression of the bradykinin response was instead observed in the absence of ASA.
Negative_regulation (suppression) of bradykinin associated with bradykinin
11) Confidence 0.41 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 8177499 Disease Relevance 0 Pain Relevance 0.26
On the other hand, morphine-induced blockade of bradykinin (BK, a B(2)-receptor agonist)-responses was attenuated by pertussis toxin (PTX) treatment, whereas that of spinorphin was not.
Negative_regulation (blockade) of bradykinin associated with bordatella infection, agonist, bradykinin and morphine
12) Confidence 0.41 Published 2000 Journal Peptides Section Abstract Doc Link 11035208 Disease Relevance 0.17 Pain Relevance 0.84
Their effects are mediated by at least two types of bradykinin receptors--B1 and B2.
Negative_regulation (types) of bradykinin associated with b1 receptor and bradykinin
13) Confidence 0.41 Published 2001 Journal Ginekol. Pol. Section Abstract Doc Link 11757483 Disease Relevance 0.19 Pain Relevance 0.28
Substance P (Ki = 2.5 micromol/liter) and bradykinin (Ki = 27 micromol/liter) were shown to be potent inhibitors of the serum aminopeptidase-M.
Negative_regulation (inhibitors) of bradykinin associated with bradykinin and substance p
14) Confidence 0.41 Published 2002 Journal Dig. Dis. Sci. Section Abstract Doc Link 12184528 Disease Relevance 0.47 Pain Relevance 0.19
After a number of passages, the rates of Leu-enkephalin and bradykinin decomposition by cultivated cells were diminished as compared to their counterparts before in vitro aging.
Negative_regulation (diminished) of bradykinin associated with aging, enkephalin and bradykinin
15) Confidence 0.41 Published 1992 Journal Pharmazie Section Abstract Doc Link 1492115 Disease Relevance 0.17 Pain Relevance 0.15
Both cyclic GMP and sodium nitroprusside induced a long lasting reduction of bradykinin responsiveness in peripheral fibres.
Negative_regulation (reduction) of bradykinin associated with bradykinin
16) Confidence 0.38 Published 1994 Journal Neuropharmacology Section Abstract Doc Link 7862249 Disease Relevance 0 Pain Relevance 0.59
In addition, the effect of topical capsaicin was to completely inhibit the bradykinin induced weal response compared to control, the mean weal area (95% CI) being reduced from 13.4 (11.4-15.4) mm2 to 8.2 (5.3-11.0) mm2 (P < 0.01).
Negative_regulation (inhibit) of bradykinin associated with qutenza, wheal and bradykinin
17) Confidence 0.37 Published 1992 Journal Clin. Exp. Allergy Section Abstract Doc Link 1464049 Disease Relevance 0.59 Pain Relevance 1.03
Pretreatment with nitric oxide inhibitors also prevented, in part (methylene blue, 1 microM) or in full (N omega-nitro-L-arginine, 100 microM), the relaxant effect of bradykinin.
Negative_regulation (effect) of bradykinin associated with bradykinin
18) Confidence 0.36 Published 1994 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 8012902 Disease Relevance 0.05 Pain Relevance 0.27
These results show that preganglionic sympathectomy does not diminish bradykinin-induced protein extravasation as found for postganglionic sympathectomy in rats.


Neg (not) Negative_regulation (diminish) of bradykinin
19) Confidence 0.35 Published 2010 Journal Pain Med Section Body Doc Link 20202140 Disease Relevance 0 Pain Relevance 0
Although this is the largest trial of a Bradykinin B2 receptor antagonist in TBI conducted so far, it was small, and even in aggregate the total number of participants in clinical trials of B2 Receptor antagonists is less than 400 patients.
Negative_regulation (antagonist) of Bradykinin associated with antagonist, b2 receptor and brain injury
20) Confidence 0.31 Published 2009 Journal Trials Section Body Doc Link PMC2794266 Disease Relevance 0.62 Pain Relevance 0.26

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox