INT60813

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Context Info
Confidence 0.60
First Reported 1995
Last Reported 2005
Negated 1
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 3.40
Pain Relevance 4.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR1D) signal transducer activity (HTR1D)
Anatomy Link Frequency
blood 1
blood vessels 1
endothelium 1
GABAergic neurons 1
HTR1D (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 31 99.64 Very High Very High Very High
agonist 14 99.60 Very High Very High Very High
antagonist 10 99.60 Very High Very High Very High
Sumatriptan 19 98.96 Very High Very High Very High
gABA 5 97.32 Very High Very High Very High
GABAergic 1 96.56 Very High Very High Very High
headache 1 96.08 Very High Very High Very High
Triptan 5 94.96 High High
Pain 5 85.24 High High
Serotonin 10 80.28 Quite High
Disease Link Frequency Relevance Heat
Small Cell Lung Cancer 3 99.86 Very High Very High Very High
Headache 5 99.64 Very High Very High Very High
Autism 14 99.52 Very High Very High Very High
Migraine Disorders 26 99.20 Very High Very High Very High
Congenital Anomalies 2 98.28 Very High Very High Very High
Increased Venous Pressure Under Development 5 95.16 Very High Very High Very High
Pain 5 85.24 High High
Depression 2 78.64 Quite High
Small Cell Lung Carcinoma 1 75.00 Quite High
Lung Cancer 1 68.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, agents that modulate 5-HT1B, 5-HT1D, 5-HT1F and 5-HT2B receptors either have or may have clinical utility in the therapy of migraine headache.
Regulation (modulate) of 5-HT1D associated with migraine and headache
1) Confidence 0.60 Published 1998 Journal Prog Drug Res Section Abstract Doc Link 9949863 Disease Relevance 1.20 Pain Relevance 1.61
We studied the effects of 5-HT1D receptor stimulation on neocortical [3H] gamma-aminobutyric acid (GABA) release from GABAergic neurons in these species.
Regulation (effects) of 5-HT1D in GABAergic neurons associated with gaba and gabaergic
2) Confidence 0.45 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8736648 Disease Relevance 0.08 Pain Relevance 0.49
CONCLUSIONS: Our study indicated that 5-HT1D receptors are not involved in PRL and GH secretion in middle-aged acromegalics.


Neg (not) Regulation (involved) of 5-HT1D
3) Confidence 0.44 Published 1995 Journal Minerva Endocrinol. Section Body Doc Link 8531896 Disease Relevance 0.05 Pain Relevance 0
These data indicate that the mitogenic effect of 5-HT in SCLC cells involves both 5-HT1A and 5-HT1D receptor types.
Regulation (involves) of 5-HT1D associated with small cell lung cancer
4) Confidence 0.44 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8566173 Disease Relevance 0.39 Pain Relevance 0.33
The effects of the recently developed 5-HT1D receptor antagonist, GR127935 (N-[4-methoxy-3-(4-methyl-1-piperazinyl) phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl) [1,1,-biphenyl]-4-carboxamide), and those of the preferential human 5-HT1D alpha receptor antagonist, ketanserin, on the isometric contraction induced by 5-hydroxytryptamine (5-HT) and sumatriptan in endothelium-denuded ring segments of canine coronary artery were analyzed.
Regulation (effects) of 5-HT1D in endothelium associated with sumatriptan and antagonist
5) Confidence 0.44 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8741174 Disease Relevance 0 Pain Relevance 0.35
The tolerability of 311C90, a novel, selective and highly effective 5-HT1D receptor agonist in development for the acute treatment of migraine, has been evaluated in a number of clinical pharmacology and patient studies across the dose range 1-50 mg. 311C90 has been well tolerated across the entire dose range and no clinically relevant changes in routine laboratory parameters, blood pressure or ECG recordings have been observed.
Regulation (effective) of 5-HT1D in blood associated with migraine and agonist
6) Confidence 0.44 Published 1996 Journal Eur. Neurol. Section Abstract Doc Link 8791026 Disease Relevance 0.10 Pain Relevance 0.15
To assess sensitivity of the 5-HT1d receptor, growth hormone response to the 5-HT1d receptor agonist sumatriptan was studied in adult autistic patients and matched normal controls.
Regulation (sensitivity) of 5-HT1d associated with sumatriptan, autism and agonist
7) Confidence 0.26 Published 2000 Journal Psychiatry Res Section Abstract Doc Link 10808042 Disease Relevance 0.51 Pain Relevance 0.30
Thus, the severity of a specific behavioral dimension in autism (repetitive behaviors) parallels the sensitivity of the 5-HT 1d receptor, as manifest by sumatriptan elicited GH response.
Regulation (sensitivity) of 5-HT 1d associated with sumatriptan and autism
8) Confidence 0.26 Published 2000 Journal Neuropsychopharmacology Section Abstract Doc Link 10649829 Disease Relevance 0.55 Pain Relevance 0.46
The 5-HT1D receptor is a potential target of anti-migraine drugs, and here its genes were cloned from chimpanzee, gorilla and rhesus monkey, via polymerase chain reactions with their genomic DNAs and the primers designed from the 5' and 3' untranslated regions of the human receptor.
Regulation (target) of 5-HT1D associated with migraine
9) Confidence 0.26 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9406883 Disease Relevance 0.10 Pain Relevance 0.10
In vitro pharmacology experiments showed that the 5-hydroxytryptamine (5-HT) type 1B and 1D receptor agonists, eletriptan, naratriptan, rizatriptan, sumatriptan, and zolmitriptan, induced vasoconstriction in the thoracic blood vessels from 38% to 57% of the patients. 5-carboxamidotryptamine (5-CT) and sumatriptan elicited a vasoconstriction that was antagonized by the 5-HT1B receptor antagonist SB224289, whereas the 5-HT1D receptor antagonist BRL115572 had no effect. 5-HT induced a contraction that was inhibited by the 5-HT2A receptor antagonist ketanserin. 5-HT2A, 5-HT1B, and 5-HT1D receptor mRNA levels were detected by real-time PCR in all blood vessels studied.
Regulation (detected) of 5-HT1D in blood vessels associated with sumatriptan, antagonist, agonist and increased venous pressure under development
10) Confidence 0.19 Published 2005 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15821444 Disease Relevance 0.42 Pain Relevance 0.89

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