INT60821

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Context Info
Confidence 0.57
First Reported 1995
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 0.69
Pain Relevance 5.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR1D) signal transducer activity (HTR1D)
Anatomy Link Frequency
blood vessels 1
brain 1
HTR1D (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 1 100.00 Very High Very High Very High
Sumatriptan 21 99.26 Very High Very High Very High
agonist 40 99.24 Very High Very High Very High
antagonist 21 99.04 Very High Very High Very High
Pain 1 98.40 Very High Very High Very High
Migraine 2 97.04 Very High Very High Very High
alcohol 3 96.28 Very High Very High Very High
tetrodotoxin 2 92.80 High High
ergotamine 5 92.64 High High
noradrenaline 12 87.44 High High
Disease Link Frequency Relevance Heat
Small Cell Lung Cancer 2 98.80 Very High Very High Very High
Pain 1 98.40 Very High Very High Very High
Headache 2 97.04 Very High Very High Very High
Vomiting 2 88.96 High High
Cluster Headache 1 77.48 Quite High
Lung Cancer 2 75.00 Quite High
Depression 1 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data show a persistent selective loss of 5-HT1D receptor and GHB-mediated neurotransmissions in alcoholics that a long-term abstinence from alcohol is unable to restore.
Negative_regulation (loss) of 5-HT1D associated with alcohol
1) Confidence 0.57 Published 1997 Journal Alcohol Alcohol. Section Abstract Doc Link 9131896 Disease Relevance 0 Pain Relevance 0.54
Ketanserin at a concentration which should block the 5-HT 1D alpha but not the 5-HT 1D beta receptor failed to antagonize the inhibitory effect of 5-carboxamidotryptamine.
Negative_regulation (block) of 5-HT 1D
2) Confidence 0.41 Published 1995 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8532076 Disease Relevance 0 Pain Relevance 0.22
CONCLUSIONS: These results suggest reduced sensitivity of 5-HT1D receptors in major depression.
Negative_regulation (reduced) of 5-HT1D
3) Confidence 0.41 Published 1998 Journal Psychol Med Section Body Doc Link 9572087 Disease Relevance 0 Pain Relevance 0
These findings constitute the first evidence of a reciprocal negative interference between human 5-HT1A and 5-HT1D receptors, and indicate that SCLC GLC-8 cells simultaneously express both receptor subtypes.
Negative_regulation (interference) of 5-HT1D associated with small cell lung cancer
4) Confidence 0.41 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9016944 Disease Relevance 0.17 Pain Relevance 0.45
The labelling conditions to visualize 5-HT1F receptors in guinea pig brain, namely 3H-sumatriptan in the presence of 10(-8) M 5-CT to block 5-HT1D receptors, are suitable for visualizing this receptor, since the results agreed with those observed by in situ hybridization.
Negative_regulation (block) of 5-HT1D in brain associated with sumatriptan
5) Confidence 0.41 Published 1996 Journal Histochem. J. Section Abstract Doc Link 8968727 Disease Relevance 0 Pain Relevance 0.25
In contrast, ketanserin at a concentration which should block the 5-HT1D alpha, but not the 5-HT1D beta, receptor did not alter the inhibitory effect of 5-CT on tritium overflow.
Negative_regulation (block) of 5-HT1D
6) Confidence 0.41 Published 1996 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8692282 Disease Relevance 0 Pain Relevance 0.38
In contrast, ketanserin at a concentration which should block the 5-HT1D alpha, but not the 5-HT1D beta, receptor did not alter the inhibitory effect of 5-CT on tritium overflow.
Negative_regulation (block) of 5-HT1D
7) Confidence 0.41 Published 1996 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8692282 Disease Relevance 0 Pain Relevance 0.37
Ketanserin at a concentration which should block 5-HT1D alpha but not 5-HT1D beta receptors and methiothepin at a concentration which may be assumed to block both 5-HT1D alpha and 5-HT1D beta receptors antagonized the inhibitory effect of 5-HT.
Negative_regulation (block) of 5-HT1D
8) Confidence 0.41 Published 1996 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8692281 Disease Relevance 0 Pain Relevance 0.34
Ketanserin at a concentration which should block 5-HT1D alpha but not 5-HT1D beta receptors and methiothepin at a concentration which may be assumed to block both 5-HT1D alpha and 5-HT1D beta receptors antagonized the inhibitory effect of 5-HT.
Negative_regulation (block) of 5-HT1D
9) Confidence 0.41 Published 1996 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8692281 Disease Relevance 0 Pain Relevance 0.34
Ketanserin at a concentration which should block 5-HT1D alpha but not 5-HT1D beta receptors and methiothepin at a concentration which may be assumed to block both 5-HT1D alpha and 5-HT1D beta receptors antagonized the inhibitory effect of 5-HT.
Negative_regulation (block) of 5-HT1D
10) Confidence 0.41 Published 1996 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8692281 Disease Relevance 0 Pain Relevance 0.41
Ketanserin at a concentration which should block 5-HT1D alpha but not 5-HT1D beta receptors and methiothepin at a concentration which may be assumed to block both 5-HT1D alpha and 5-HT1D beta receptors antagonized the inhibitory effect of 5-HT.
Negative_regulation (block) of 5-HT1D
11) Confidence 0.41 Published 1996 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8692281 Disease Relevance 0 Pain Relevance 0.40
Sumatriptan, GR127935 and metergoline (each 0.01-1 microM) behaved as agonists, producing a concentration-dependent inhibition of forskolin-stimulated adenosine 3',5'-cyclic monophosphate (cAMP) production at both 5-HT1D alpha and 5-HT1D beta receptor subtypes (mean pIC50 values of 8.4 and 8.3 for sumatriptan, 7.9 and 8.0 for GR127935, and 7.9 and 8.3 for metergoline, respectively).
Negative_regulation (inhibition) of 5-HT1D associated with sumatriptan, adenocard and agonist
12) Confidence 0.41 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8666030 Disease Relevance 0 Pain Relevance 0.60
Alkyl groups longer than eight carbon atoms impart reduced affinity for 5-HT1A receptors whereas groups longer than nine carbon atoms lead to compounds with reduced affinity at 5-HT1D beta receptors. 5-(Nonyloxy)tryptamine (10) represents a compound with optimal 5-HT1D beta affinity (Ki = 1 nM) and selectivity (> 300-fold).
Negative_regulation (reduced) of 5-HT1D
13) Confidence 0.41 Published 1996 Journal J. Med. Chem. Section Abstract Doc Link 8568822 Disease Relevance 0.07 Pain Relevance 0.27
In contrast, the nonselective 5-HT 1D alpha/1D beta receptor antagonist, methiothepin, at a concentration which should block both the 5-HT 1D alpha and the 5-HT 1D beta receptor abolished the effect of 5-carboxamidotryptamine.
Negative_regulation (block) of 5-HT 1D associated with antagonist
14) Confidence 0.41 Published 1995 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8532076 Disease Relevance 0 Pain Relevance 0.21
In acute migraine treatment, their mechanisms of action involve constricting the pain-producing intracranial extracerebral blood vessels at the 5-HT1B receptors and inhibiting the trigeminal neurotransmission at the peripheral and central 5-HT1D receptors.
Negative_regulation (inhibiting) of 5-HT1D in blood vessels associated with pain and migraine
15) Confidence 0.41 Published 2003 Journal Headache Section Abstract Doc Link 12558771 Disease Relevance 0.45 Pain Relevance 0.47

General Comments

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