INT60860

Context Info Confidence 0.66 First Reported 1995 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 32 Total Number 33 Disease Relevance 8.55 Pain Relevance 1.34

extracellular space (Slmap) plasma membrane (Slmap) cytoskeleton (Slmap) cytoplasm (Slmap)

Anatomy Link Frequency anterior 5 SLAP 5 shoulder 4 tear 2 tendon 1 Slmap (Mus musculus)

Pain Link Frequency Relevance Heat imagery 102 99.72 shoulder pain 66 99.10 Pain 148 88.88 anesthesia 8 73.88 Perioperative pain 16 32.72 visual analogue scale 56 5.00 Lasting pain 9 5.00 Tendonitis 9 5.00 cva 5 5.00 alcohol 2 5.00

Disease Link Frequency Relevance Heat Syndrome 27 99.92 Injury 418 99.80 Shoulder Pain 66 99.10 Stress 13 97.20 Dislocations 140 96.48 Rotator Cuff Tears 36 93.44 Ganglion Cysts 3 92.64 Bursitis 27 91.96 Contracture 5 91.12 Cyst 6 90.28

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Considering 50% of patients had SLAP lesions in this study, with 86% having concomitant injuries with the SLAP lesion, it is feasible that it was going to be unachievable to diagnose SLAP lesions utilising only O'Brien's test.

Gene_expression (lesion) of SLAP associated with injury

1) Confidence 0.66 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2821297 Disease Relevance 0.17 Pain Relevance 0

This investigation however, analysed all patients irrespective of severity and type of shoulder pathology, including all individuals with SLAP lesions.

Gene_expression (lesions) of SLAP in shoulder

2) Confidence 0.66 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2821297 Disease Relevance 0.16 Pain Relevance 0

Considering 50% of patients had SLAP lesions in this study, with 86% having concomitant injuries with the SLAP lesion, it is feasible that it was going to be unachievable to diagnose SLAP lesions utilising only O'Brien's test.

Gene_expression (lesions) of SLAP associated with injury

3) Confidence 0.66 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2821297 Disease Relevance 0.17 Pain Relevance 0

The most common operative finding was a grade II or III SLAP lesion, evident in 50.4% (n = 51) of patients with only 7 patients having an isolated SLAP lesion.

Gene_expression (lesion) of SLAP

4) Confidence 0.66 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2821297 Disease Relevance 0.38 Pain Relevance 0.22

Lo and Burkhart10) passed a suture through the SLAP lesion, closed the Bankart lesion, and then finished the SLAP lesion repair in the cases of triple labral lesions (anterior, posterior, and superior labral tears).

Gene_expression (lesion) of SLAP in superior

5) Confidence 0.64 Published 2010 Journal Clinics in Orthopedic Surgery Section Body Doc Link PMC2824094 Disease Relevance 0.42 Pain Relevance 0

Considering that a history of trauma was observed and led to anterior instability in all patients in our study and symptoms associated with the SLAP lesions were not noted before the traumatic event, we believe that recurrent anteroinferior instability was mainly responsible for the SLAP lesions.

Gene_expression (lesions) of SLAP in anterior associated with injury

6) Confidence 0.64 Published 2010 Journal Clinics in Orthopedic Surgery Section Body Doc Link PMC2824094 Disease Relevance 0.61 Pain Relevance 0

Considering that a history of trauma was observed and led to anterior instability in all patients in our study and symptoms associated with the SLAP lesions were not noted before the traumatic event, we believe that recurrent anteroinferior instability was mainly responsible for the SLAP lesions.

Gene_expression (lesions) of SLAP in anterior associated with injury

7) Confidence 0.64 Published 2010 Journal Clinics in Orthopedic Surgery Section Body Doc Link PMC2824094 Disease Relevance 0.58 Pain Relevance 0

Repairs of relatively extensive labral tears such as combined Bankart and SLAP lesions can result in restrictions on the range of motion.

Gene_expression (lesions) of SLAP in tears

8) Confidence 0.64 Published 2010 Journal Clinics in Orthopedic Surgery Section Body Doc Link PMC2824094 Disease Relevance 0.15 Pain Relevance 0

Nineteen percent of Rockwood V lesions had associated SLAP lesions (SLAP I excluded), whereas only 3.4% of Rockwood IV lesions showed SLAP lesions.

Gene_expression (lesions) of SLAP in SLAP

9) Confidence 0.62 Published 2009 Journal Am J Sports Med Section Body Doc Link 18725652 Disease Relevance 0.13 Pain Relevance 0

Trauma distracting this tendon can tear the superior glenoid labrum, producing the superior labrum anterior to posterior (SLAP) syndrome.

Gene_expression (producing) of SLAP in tear associated with syndrome and injury

10) Confidence 0.58 Published 1995 Journal Am J Phys Med Rehabil Section Abstract Doc Link 8534390 Disease Relevance 0.44 Pain Relevance 0.18

In addition, intra-articular free bodies were present in 2 SLAP lesions, and a capsular tear was present in 1.

Gene_expression (present) of SLAP in SLAP

11) Confidence 0.58 Published 2009 Journal Orthopedics Section Abstract Doc Link 19708636 Disease Relevance 0.06 Pain Relevance 0.06

Both patients following 1 year after the surgery, complained of nonspecific shoulder pain and magnetic resonance imaging revealed new SLAP lesion which was treated arthroscopically.

Gene_expression (lesion) of SLAP in shoulder associated with shoulder pain and imagery

12) Confidence 0.58 Published 2009 Journal Knee Surg Sports Traumatol Arthrosc Section Abstract Doc Link 19565219 Disease Relevance 0.44 Pain Relevance 0.15

Despite O'Brien's test having on average, the highest sensitivity, likelihood ratio, PPV and over-all accuracy for diagnosing SLAP lesions in this study, these values are mediocre and consequently this study is unable to validate this test, or any other, as a single accurate, reliable tool for diagnosing SLAP lesions.

Gene_expression (lesions) of SLAP

13) Confidence 0.58 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2821297 Disease Relevance 0.17 Pain Relevance 0

No one test utilised in the clinical examination in this study, attained high values in all diagnostic categories thereby suggesting that no single test is both sensitive and specific in diagnosing SLAP lesions, a conclusion supported by Parentis et al [12].

Gene_expression (lesions) of SLAP

14) Confidence 0.58 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2821297 Disease Relevance 0.21 Pain Relevance 0

Despite O'Brien's test having on average, the highest sensitivity, likelihood ratio, PPV and over-all accuracy for diagnosing SLAP lesions in this study, these values are mediocre and consequently this study is unable to validate this test, or any other, as a single accurate, reliable tool for diagnosing SLAP lesions.

Gene_expression (lesions) of SLAP

15) Confidence 0.58 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2821297 Disease Relevance 0.16 Pain Relevance 0

Considering 50% of patients had SLAP lesions in this study, with 86% having concomitant injuries with the SLAP lesion, it is feasible that it was going to be unachievable to diagnose SLAP lesions utilising only O'Brien's test.

Gene_expression (lesions) of SLAP associated with injury

16) Confidence 0.58 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2821297 Disease Relevance 0.18 Pain Relevance 0

SLAP lesions

Gene_expression (lesions) of SLAP

17) Confidence 0.58 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2821297 Disease Relevance 0.06 Pain Relevance 0

The result showed that patients' shoulder functions improved (UCLA Shoulder Score), and symptoms of SLAP lesion reduced (O'Brien test, Speed test, and Yergason test) significantly (P<0.05).

Gene_expression (lesion) of SLAP in Shoulder

18) Confidence 0.56 Published 2008 Journal Knee Surg Sports Traumatol Arthrosc Section Abstract Doc Link 18818900 Disease Relevance 0.26 Pain Relevance 0.09

According to Warner et al.,18) arthroscopic repair of 7 cases of combined Bankart and SLAP lesions using absorbable anchors (Suretec; Acufex, Mansfield, MA, USA) resulted in 1 recurrent dislocation and 1 reoperation due to stiffness during the ?

Gene_expression (lesions) of SLAP associated with dislocations

19) Confidence 0.56 Published 2010 Journal Clinics in Orthopedic Surgery Section Body Doc Link PMC2824094 Disease Relevance 0.39 Pain Relevance 0

A 5.5 mm cannula (Linvatec, Largo, FL, USA) was inserted through the anterior portal and an instrument was passed through this cannula to observe the extent of a Bankart lesion and the presence of a SLAP lesion (Fig. 3).

Gene_expression (lesion) of SLAP in anterior

20) Confidence 0.56 Published 2010 Journal Clinics in Orthopedic Surgery Section Body Doc Link PMC2824094 Disease Relevance 0.13 Pain Relevance 0.07

General Comments

This test has worked.