INT60865

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Context Info
Confidence 0.73
First Reported 1995
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 20
Total Number 22
Disease Relevance 2.10
Pain Relevance 12.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (G2e3) Golgi apparatus (G2e3) intracellular (G2e3)
cytoplasm (G2e3)
Anatomy Link Frequency
plasma 4
brain 2
liver 1
hair 1
tail 1
G2e3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 170 100.00 Very High Very High Very High
allodynia 4 99.96 Very High Very High Very High
antinociception 7 99.76 Very High Very High Very High
Hyperalgesia 4 99.40 Very High Very High Very High
Hippocampus 6 97.64 Very High Very High Very High
tail-flick 4 97.28 Very High Very High Very High
Catecholamine 1 96.76 Very High Very High Very High
Antinociceptive 24 95.28 Very High Very High Very High
Opioid 18 94.80 High High
Substantia gelatinosa neuron 2 93.76 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 4 99.96 Very High Very High Very High
Hyperalgesia 4 99.40 Very High Very High Very High
Chronic Renal Insufficiency 9 98.18 Very High Very High Very High
Renal Failure 7 97.20 Very High Very High Very High
Disorders Of Creatine Metabolism 5 96.32 Very High Very High Very High
Rheumatoid Arthritis 2 95.52 Very High Very High Very High
Respiratory Failure 1 82.72 Quite High
Convulsion 1 59.12 Quite High
Depression 1 49.60 Quite Low
Myoclonus 1 46.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine-6-glucuronide was not detected in any plasma or brain sample from rats administered morphine and no M3G was detected in brain. 4.
Gene_expression (detected) of M3G in brain associated with morphine
1) Confidence 0.73 Published 2000 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 10696532 Disease Relevance 0.54 Pain Relevance 1.45
High doses of intrathecally applied morphine or morphine-3beta-D-glucuronide (M3G) produce allodynia and hyperalgesia.
Gene_expression (produce) of M3G associated with hyperalgesia, allodynia and morphine
2) Confidence 0.73 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12130717 Disease Relevance 0.20 Pain Relevance 0.88
Gonadectomy only partially eliminated sex differences in morphine antinociception and plasma levels of M3G.
Gene_expression (levels) of M3G in plasma associated with antinociception and morphine
3) Confidence 0.53 Published 2002 Journal Pain Section Abstract Doc Link 11790468 Disease Relevance 0 Pain Relevance 1.77
Morphine and M3G were detected in the hair shafts and the hair roots.
Gene_expression (detected) of M3G in hair associated with morphine
4) Confidence 0.18 Published 2001 Journal Analyst Section Abstract Doc Link 11534602 Disease Relevance 0 Pain Relevance 0.94
RESULTS: Heroin induced the synthesis of M6G and decreased the synthesis of M3G.
Gene_expression (synthesis) of M3G
5) Confidence 0.12 Published 2005 Journal Psychopharmacology (Berl.) Section Body Doc Link 15986196 Disease Relevance 0 Pain Relevance 0
We have also shown that heroin-treated rats exhibit measurable levels of M6G (which is usually undetectable in this species) and reduced levels of M3G.
Gene_expression (levels) of M3G
6) Confidence 0.12 Published 2005 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 15986196 Disease Relevance 0 Pain Relevance 0.62
Naltrexone exhibited intrinsic modulatory activity on morphine glucuronidation, increasing the synthesis of M3G via a low-affinity/high-capacity reaction characterized by positive cooperativity.
Gene_expression (synthesis) of M3G
7) Confidence 0.09 Published 2005 Journal Psychopharmacology (Berl.) Section Body Doc Link 15986196 Disease Relevance 0 Pain Relevance 0
The rate of M3G synthesis in the heroin + naltrexone groups was not different from that of the naltrexone groups.
Gene_expression (synthesis) of M3G
8) Confidence 0.09 Published 2005 Journal Psychopharmacology (Berl.) Section Body Doc Link 15986196 Disease Relevance 0 Pain Relevance 0
M6G was not detected in any plasma or brain sample from rats administered morphine and no M3G was detected in brain.
Gene_expression (detected) of M3G in brain associated with morphine
9) Confidence 0.09 Published 1997 Journal Pain Section Abstract Doc Link 9211481 Disease Relevance 0.17 Pain Relevance 1.44
We have previously found that repeated exposure to heroin reduces liver synthesis of morphine-3-glucuronide (M3G) and increases the production of morphine-6-glucuronide (M6G), which normally is not formed in the rat.
Gene_expression (synthesis) of M3G in liver associated with morphine
10) Confidence 0.09 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18639530 Disease Relevance 0 Pain Relevance 0.20
The goal of the present study was to investigate the role of UGT1A1 and UGT2B1 in the effects of heroin and naltrexone by determining their influence on the synthesis of E3G and E17G.
Gene_expression (synthesis) of E3G
11) Confidence 0.09 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18639530 Disease Relevance 0 Pain Relevance 0.15
Methadone and ethanol induced a modest increase in M3G synthesis and had no effect on M6G synthesis.
Gene_expression (synthesis) of M3G
12) Confidence 0.08 Published 2005 Journal Psychopharmacology (Berl.) Section Body Doc Link 15986196 Disease Relevance 0 Pain Relevance 0
RESULTS: Heroin inhibited M3G synthesis and induced the formation of M6G, which under basal conditions is not synthesized in rats.
Gene_expression (synthesis) of M3G
13) Confidence 0.08 Published 2008 Journal Drug Alcohol Depend Section Body Doc Link 18597954 Disease Relevance 0 Pain Relevance 0
The amount of M3G and M6G synthesized was then measured by HPLC method.
Gene_expression (synthesized) of M3G
14) Confidence 0.08 Published 2008 Journal Drug Alcohol Depend Section Body Doc Link 18597954 Disease Relevance 0 Pain Relevance 0
Pre-incubation with naltrexone alone slightly increased M3G synthesis, but had no effect on M6G formation.
Gene_expression (synthesis) of M3G
15) Confidence 0.07 Published 2008 Journal Drug Alcohol Depend Section Body Doc Link 18597954 Disease Relevance 0 Pain Relevance 0
M3G synthesis depends on the activity of two isoforms of the UDP-glucuronosyltransferase (UGT), UGT1A1 and UGT2B1.
Gene_expression (synthesis) of M3G
16) Confidence 0.07 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18639530 Disease Relevance 0 Pain Relevance 0.18
No morphine or M3G was detected in any of the plasma or brain samples of rats administered M6G.
Gene_expression (detected) of M3G in plasma associated with morphine
17) Confidence 0.06 Published 1997 Journal Pain Section Abstract Doc Link 9211481 Disease Relevance 0.15 Pain Relevance 1.22
Substitution tests were conducted with SC or ICV morphine, morphine-3-beta-D-glucuronide (M3G), or morphine-6-beta-D-glucuronide (M6G) and response latency in a tail-flick test was measured before each session began.
Gene_expression (conducted) of M3G in tail associated with tail-flick and morphine
18) Confidence 0.05 Published 1998 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9862407 Disease Relevance 0 Pain Relevance 0.87
Though no significant hormonal change was observed in H2O, M3G, and M6G injected animals, the combination of M3G + M6G resulted in a significant increase in circulating catecholamine levels with no alterations in plasma corticosterone, insulin, and glucagon.
Gene_expression (animals) of M3G in plasma associated with catecholamine
19) Confidence 0.05 Published 1995 Journal Brain Res. Bull. Section Abstract Doc Link 8535854 Disease Relevance 0.18 Pain Relevance 0.22
This study was designed to determine in rats whether morphine-3-glucuronide (M3G) produces its neuro-excitatory effects most potently in the ventral hippocampus (as has been reported previously for subanalgesic doses of opioid peptides).
Gene_expression (produces) of M3G in ventral associated with hippocampus, opioid and morphine
20) Confidence 0.04 Published 1999 Journal Life Sci. Section Abstract Doc Link 10416828 Disease Relevance 0 Pain Relevance 0.46

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