INT60867

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.01
First Reported 1995
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.10
Pain Relevance 1.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (G2e3) Golgi apparatus (G2e3) intracellular (G2e3)
cytoplasm (G2e3)
Anatomy Link Frequency
hepatocytes 1
Liver 1
central nervous system 1
G2e3 (Rattus norvegicus)
Gpm6a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 19 100.00 Very High Very High Very High
Central nervous system 1 99.62 Very High Very High Very High
Opioid 5 99.20 Very High Very High Very High
Antinociceptive 1 94.76 High High
antagonist 3 93.56 High High
MU agonist 1 88.88 High High
mu opioid receptor 6 84.08 Quite High
agonist 4 82.08 Quite High
methadone 2 73.36 Quite High
Catecholamine 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Depression 1 95.84 Very High Very High Very High
Rheumatoid Arthritis 2 48.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study addressed the metabolic effects of direct central nervous system administration of M3G and its interaction with the hyperglycemic effects of M6G.
M3G Binding (interaction) of M6G in central nervous system associated with central nervous system
1) Confidence 0.01 Published 1995 Journal Brain Res. Bull. Section Abstract Doc Link 8535854 Disease Relevance 0.10 Pain Relevance 0.92
BACKGROUND: Liver metabolism of morphine leads to the formation of morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G), the latter possessing strong opioid activity that however differs from that of the parent compound.
M3G Binding (formation) of M6G in Liver associated with opioid and morphine
2) Confidence 0.01 Published 2008 Journal Drug Alcohol Depend Section Abstract Doc Link 18597954 Disease Relevance 0 Pain Relevance 1.01
METHODS: In the present study, we measured the in vitro formation of M3G and M6G by rat hepatocytes incubated for 120 min with morphine (0.1-1.0 mM) after 72h pre-incubation with one of the following MOR agonists: heroin (3.3 or 6.6 microM), morphine (7.8 microM), or methadone (12 microM).
M3G Binding (formation) of M6G in hepatocytes
3) Confidence 0.01 Published 2008 Journal Drug Alcohol Depend Section Body Doc Link 18597954 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox