INT60930

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Context Info
Confidence 0.41
First Reported 1995
Last Reported 1995
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.64
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Abt1) RNA binding (Abt1) nucleus (Abt1)
DNA binding (Abt1)
Anatomy Link Frequency
brain 1
Abt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nicotine 12 99.64 Very High Very High Very High
agonist 4 86.40 High High
antinociception 2 82.32 Quite High
Potency 2 74.56 Quite High
antagonist 2 56.48 Quite High
Disease Link Frequency Relevance Heat
Anxiety Disorder 2 94.00 High High
Cognitive Disorder 2 93.00 High High
Hypothermia 4 83.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ABT-418 binds with high affinity to 3H-nicotine binding sites in the brain with, however, a Ki (6 nM) less than that of nicotine (four-fold).
ABT-418 Binding (binds) of in brain associated with nicotine
1) Confidence 0.41 Published 1995 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 8539331 Disease Relevance 0.32 Pain Relevance 0.49
In this study, the binding properties of ABT-418 to [3H]-nicotine sites were evaluated and its pharmacology investigated in different tests in laboratory animals.
ABT-418 Binding (binding) of associated with nicotine
2) Confidence 0.30 Published 1995 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 8539331 Disease Relevance 0.32 Pain Relevance 0.42

General Comments

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