INT60931

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Context Info
Confidence 0.57
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 16
Disease Relevance 5.44
Pain Relevance 7.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Fst) nucleus (Fst) cellular_component (Fst)
cytoplasm (Fst)
Anatomy Link Frequency
neuronal 1
dentate gyrus 1
pituitary 1
Fst (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Eae 134 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 2 99.98 Very High Very High Very High
agonist 38 99.70 Very High Very High Very High
antidepressant 188 99.64 Very High Very High Very High
antagonist 80 99.24 Very High Very High Very High
fluoxetine 42 99.20 Very High Very High Very High
monoamine 8 98.90 Very High Very High Very High
Hippocampus 27 98.82 Very High Very High Very High
tramadol 22 98.34 Very High Very High Very High
midbrain 1 98.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anxiety Disorder 264 98.60 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 6 97.96 Very High Very High Very High
Overactive Bladder 12 95.16 Very High Very High Very High
Depression 177 91.68 High High
Aggression 4 84.40 Quite High
Stress 144 84.24 Quite High
Depressive Disorder 3 81.44 Quite High
Endometriosis (extended) 31 80.16 Quite High
Sprains And Strains 4 77.76 Quite High
Pain 5 73.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we report that i.c.v. administration of the kappa-antagonist nor-binaltorphimine dose dependently decreased immobility in the FST, suggesting that it has antidepressant-like effects.
Negative_regulation (decreased) of FST associated with antidepressant, eae and antagonist
1) Confidence 0.57 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12649385 Disease Relevance 0.09 Pain Relevance 0.96
Although all antidepressant drugs reduce immobility in the FST, at least two distinct active behavioral patterns are produced by pharmacologically selective antidepressant drugs.
Negative_regulation (reduce) of FST associated with antidepressant and serotonin
2) Confidence 0.43 Published 1999 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 10591883 Disease Relevance 0 Pain Relevance 0.38
CoCl2 injection into the BNST before either the pretest or test sessions reduced immobility in the FST, suggesting an antidepressant-like effect.
Negative_regulation (reduced) of FST associated with antidepressant
3) Confidence 0.42 Published 2010 Journal Behav Brain Funct Section Abstract Doc Link PMC2887770 Disease Relevance 0.24 Pain Relevance 0.24
Five different antidepressant drugs which block monoamine uptake and two 5-HT1A receptor agonists were shown to decrease immobility in the FST; however, they produced distinct patterns of active behaviors.
Negative_regulation (decrease) of FST associated with antidepressant, agonist and monoamine
4) Confidence 0.38 Published 1995 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 8539342 Disease Relevance 0 Pain Relevance 0.55
The serotonergic compounds, fluoxetine and 8-OH-DPAT, produced dose-dependent reductions of immobility and increases of swimming behavior in the FST in SD rats, but the response to the serotonergic drugs were blunted in WKY rats.
Negative_regulation (reductions) of FST associated with fluoxetine
5) Confidence 0.38 Published 2000 Journal Neuropsychopharmacology Section Abstract Doc Link 10649831 Disease Relevance 0.29 Pain Relevance 0.39
These treatments also decreased the immobility duration in the FST consistent with an antidepressant-like effect in this test.
Negative_regulation (decreased) of FST associated with antidepressant
6) Confidence 0.37 Published 2008 Journal Pharmacol Rep Section Abstract Doc Link 19211979 Disease Relevance 0.65 Pain Relevance 0.48
Injection of CoCl2 into the BNST before the pretest (170 ± 21 vs 46 ± 13 s, t9 = 5.024, P < 0.001) or the test (182 ± 20 vs 111 ± 17 s, t10 = 2.627, P < 0.05) sessions induced a significant reduction of immobility time in the FST (Figure 2).
Negative_regulation (reduction) of FST
7) Confidence 0.36 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2887770 Disease Relevance 0 Pain Relevance 0.06
Treatment with tramadol, given (30 min earlier) by oral route (p.o.) at the doses of 10, 20 and 40 mg/kg, decreased immobility time in the FST.
Negative_regulation (decreased) of FST associated with tramadol
8) Confidence 0.35 Published 2008 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 18773934 Disease Relevance 0.15 Pain Relevance 1.23
Treatment of animals with a sub-effective dose of tramadol (5 mg/kg, p.o.) produced a synergistic antidepressant-like effect with N(G)-nitro-L-arginine (L-NNA, 3 mg/kg, i.p., an inhibitor of nitric oxide synthase) or with 7-nitroindazole (7-NI, 9 mg/kg i.p., a specific neuronal nitric oxide synthase inhibitor) in the FST.
Negative_regulation (inhibitor) of FST in neuronal associated with tramadol, antidepressant and neuronal nitric oxide synthase
9) Confidence 0.35 Published 2008 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 18773934 Disease Relevance 0.06 Pain Relevance 1.09
In addition, learned helplessness in the FST was inhibited by dioscorea at 1500 mg/kg/day.
Negative_regulation (inhibited) of FST associated with eae
10) Confidence 0.29 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1971263 Disease Relevance 1.35 Pain Relevance 0.15
E2) exhibited a significant reduction of immobility time in the FST (73.80 ± 0.80 seconds, ie, 53.99 % reduction) and hyperactivity in OFT (23.00 ± 1.14 counts, ie, 24.34 % reduction), compared with the OBX-group (Figure 1).


Negative_regulation (reduction) of FST associated with attention deficit hyperactivity disorder
11) Confidence 0.29 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2518376 Disease Relevance 0.25 Pain Relevance 0
The results show that MAR decreases immobility in FST and increases avoidance response in LH indicating antidepressant activity.
Negative_regulation (decreases) of FST associated with antidepressant and eae
12) Confidence 0.25 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 18692086 Disease Relevance 0.32 Pain Relevance 0.46
Despair behavior in the FST was inhibited by the highest dosage of dioscorea.


Negative_regulation (inhibited) of FST associated with eae
13) Confidence 0.21 Published 2007 Journal Ann Gen Psychiatry Section Abstract Doc Link PMC1971263 Disease Relevance 0.91 Pain Relevance 0.14
In addition, learned helplessness in the FST was decreased by the highest dosage of dioscorea.
Negative_regulation (decreased) of FST associated with eae
14) Confidence 0.21 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1971263 Disease Relevance 0.87 Pain Relevance 0.25
Central administration (in rats) of BDNF in Midbrain [282] and dentate gyrus of Hippocampus reversed escape deficits in learned helplessness test and decreased duration of immobility in FST without influencing locomotor status [278].
Negative_regulation (decreased) of FST in dentate gyrus associated with eae, hippocampus, midbrain and bdmf
15) Confidence 0.15 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687932 Disease Relevance 0.26 Pain Relevance 0.77
During the oestrous cycle in the rat, pituitary follistatin levels are high before the primary gonadotrophin surge, decrease on pro-oestrous evening, and rise again at midnight on pro-oestrous before returning to basal levels on oestrous morning when the second FSH peak occurs (509, 510).
Negative_regulation (decrease) of follistatin in pituitary
16) Confidence 0.08 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.07

General Comments

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