INT60933

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Context Info
Confidence 0.67
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 11.69
Pain Relevance 3.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Apcs) extracellular region (Apcs) protein complex assembly (Apcs)
protein complex (Apcs)
Anatomy Link Frequency
blood 4
sciatic nerves 1
spinal cord 1
neurons 1
Apcs (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Rostral ventrolateral medulla 313 99.84 Very High Very High Very High
Spinal cord 10 99.62 Very High Very High Very High
Sciatic nerve 4 99.50 Very High Very High Very High
Dorsal horn 1 97.40 Very High Very High Very High
Hyperalgesia 3 95.68 Very High Very High Very High
Inflammatory response 15 91.52 High High
Inflammatory mediators 21 87.08 High High
Antinociceptive 1 87.04 High High
Central nervous system 38 86.48 High High
Eae 2 85.80 High High
Disease Link Frequency Relevance Heat
Pancreatitis 139 100.00 Very High Very High Very High
Obstructive Jaundice 85 100.00 Very High Very High Very High
Heart Rate Under Development 32 99.60 Very High Very High Very High
Pressure Volume 2 Under Development 27 99.42 Very High Very High Very High
Hypoxia 45 99.06 Very High Very High Very High
Injury 20 98.78 Very High Very High Very High
Endotoxemia 10 98.68 Very High Very High Very High
Apoptosis 48 97.64 Very High Very High Very High
Anaphylaxis 5 96.44 Very High Very High Very High
Necrosis 34 96.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fifteen days after injury, the analysis in the sciatic nerves highlighted a bilateral increase of the activated forms of PKCgamma, ERK 1,2 and SAP/JNK, whereas c-Jun showed an increase only ipsilaterally.
Positive_regulation (increase) of SAP in sciatic nerves associated with injury and sciatic nerve
1) Confidence 0.67 Published 2010 Journal Neuroscience Section Abstract Doc Link 19925851 Disease Relevance 0.57 Pain Relevance 0.60
In SAP and OJ, PLA2 is activated and massively released into the blood.
Positive_regulation (activated) of SAP in blood associated with pancreatitis and obstructive jaundice
2) Confidence 0.63 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2822241 Disease Relevance 1.81 Pain Relevance 0.22
In the lumbar tract of the spinal cord, higher levels of activated PKCgamma, ERK 1,2, p38, SAP/JNK and c-Jun proteins were detected in the ipsilateral side in respect of sham.
Positive_regulation (activated) of SAP in spinal cord associated with spinal cord
3) Confidence 0.45 Published 2010 Journal Neuroscience Section Abstract Doc Link 19925851 Disease Relevance 0.59 Pain Relevance 0.70
The depressed SAP-VLF and SAP-LF components sustained the period of spontaneous recovery and subsequent retransfusion of shed blood, although the power of SAP-VHF component gradually elevated during these two periods.
Positive_regulation (elevated) of SAP-VHF in blood
4) Confidence 0.45 Published 1999 Journal Shock Section Abstract Doc Link 10188771 Disease Relevance 0.46 Pain Relevance 0.04
SAP was elicited after a mild startle reaction due to physical contact with an electrified prod at one end of a straight runway.
Positive_regulation (elicited) of SAP
5) Confidence 0.44 Published 1995 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 8539344 Disease Relevance 0.07 Pain Relevance 0.07
On the other hand, despite an initial anoxia during the critical time-window, animals with restored SAP and HR (Figs. 1b and 2) showed sustained augmentation of power density of LF component of SAP signals, alongside a return to normal tissue oxygen level, persistent enhancement of local blood flow and maintained temperature in the RVLM.


Positive_regulation (augmentation) of SAP in blood associated with rostral ventrolateral medulla and hypoxia
6) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2766834 Disease Relevance 1.06 Pain Relevance 0.38
Despite an abrupt and drastic bradycardia in both instances, SAP was elevated, together with a reversal in HR.
Positive_regulation (elevated) of SAP associated with heart rate under development
7) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2766834 Disease Relevance 0.40 Pain Relevance 0.12
Moreover, Salvia miltiorrhizae injection is also able to increase the survival rates of SAP and OJ rats.
Positive_regulation (increase) of SAP associated with pancreatitis and obstructive jaundice
8) Confidence 0.29 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2790077 Disease Relevance 1.41 Pain Relevance 0
In the control rats, an increase in Sap by 66 mmHg and a decrease in Pvp by 11.5 cmH(2)O were observed at 2.5 and 6 min, respectively, after antigen.
Positive_regulation (increase) of Sap
9) Confidence 0.28 Published 2007 Journal J Physiol Sci Section Abstract Doc Link 17875232 Disease Relevance 0.71 Pain Relevance 0
On the other hand, despite an initial anoxia during the critical time-window, animals with restored SAP and HR (Figs. 1b and 2) showed sustained augmentation of power density of LF component of SAP signals, alongside a return to normal tissue oxygen level, persistent enhancement of local blood flow and maintained temperature in the RVLM.


Positive_regulation (restored) of SAP in blood associated with rostral ventrolateral medulla and hypoxia
10) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2766834 Disease Relevance 1.05 Pain Relevance 0.38
Overall, these results show that CSF-circulating APCs rapidly and specifically target the CLNs under neuroinflammatory conditions.
Positive_regulation (circulating) of APCs
11) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2552991 Disease Relevance 0.82 Pain Relevance 0.04
Similar pretreatment with the selective nNOS inhibitor, 7-nitroindazole (1 pmol), on the other hand, discernibly shortened phase II and prolonged phase III endotoxemia, and induced progressive hypotension by antagonizing the rebound increase in SAP.
Positive_regulation (increase) of SAP associated with endotoxemia and pressure volume 2 under development
12) Confidence 0.20 Published 2001 Journal Shock Section Abstract Doc Link 11198360 Disease Relevance 0.72 Pain Relevance 0.23
Temporal changes in the power density of the LF component, pulsatile SAP, mean SAP (MSAP) and HR were routinely followed for 180 min after Mev administration in an on-line and real-time manner.


Positive_regulation (followed) of SAP
13) Confidence 0.09 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.50 Pain Relevance 0.14
In this regard, it is of interest to note that these cellular signals may be linked to angiotensin II (Ang II), a well-known peptide that is crucial to the elevation of SAP in RVLM.
Positive_regulation (elevation) of SAP associated with rostral ventrolateral medulla
14) Confidence 0.09 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.30 Pain Relevance 0.25
In summary, SSP-sap is highly effective in destroying lamina I NK-1R expressing neurons, without loss of deep NK-1R neurons.
Positive_regulation (effective) of SSP-sap in neurons
15) Confidence 0.06 Published 2007 Journal Neuroscience Section Abstract Doc Link 17418497 Disease Relevance 0.07 Pain Relevance 0.40
, interleukin (IL)-1 and nitric oxide were also reduced at 3, 6 and 12 hours after induction of SAP.
Positive_regulation (induction) of SAP associated with pancreatitis
16) Confidence 0.05 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872306 Disease Relevance 1.15 Pain Relevance 0.11

General Comments

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