INT60942

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Context Info
Confidence 0.78
First Reported 1995
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 15
Disease Relevance 12.23
Pain Relevance 2.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (S100A8) extracellular region (S100A8) plasma membrane (S100A8)
cytoskeleton (S100A8) cytoplasm (S100A8)
Anatomy Link Frequency
epithelial cells 4
monocytes 1
S100A8 (Homo sapiens)
Pain Link Frequency Relevance Heat
nud 11 99.24 Very High Very High Very High
rheumatoid arthritis 85 98.92 Very High Very High Very High
peptic ulcer disease 18 98.84 Very High Very High Very High
Arthritis 121 98.44 Very High Very High Very High
Inflammation 18 96.48 Very High Very High Very High
Inflammatory response 1 92.60 High High
cytokine 2 88.64 High High
Infliximab 1 67.28 Quite High
corticosteroid 8 17.92 Low Low
abdominal pain 9 17.04 Low Low
Disease Link Frequency Relevance Heat
Sprains And Strains 127 100.00 Very High Very High Very High
Gastritis 55 100.00 Very High Very High Very High
Disease 128 99.92 Very High Very High Very High
Ulcers 39 99.80 Very High Very High Very High
Stomach Cancer 35 99.72 Very High Very High Very High
Dyspepsia 10 99.00 Very High Very High Very High
Rheumatoid Arthritis 85 98.92 Very High Very High Very High
Lymphatic System Cancer 13 98.68 Very High Very High Very High
Seronegative Spondarthritis 116 98.44 Very High Very High Very High
Adenocarcinoma 13 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show here that such strains translocate the bacterial protein CagA into gastric epithelial cells by a type IV secretion system, encoded by the cag pathogenicity island.
Localization (translocate) of CagA in epithelial cells associated with sprains and strains
1) Confidence 0.78 Published 2000 Journal Science Section Abstract Doc Link 10688800 Disease Relevance 0.92 Pain Relevance 0.14
Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion.
Localization (Translocation) of CagA in epithelial cells associated with gastritis
2) Confidence 0.78 Published 2000 Journal Science Section Title Doc Link 10688800 Disease Relevance 0.93 Pain Relevance 0.14
The discovery of the type IV secretion system in H. pylori and its role in translocation of the CagA protein from the bacterial cell into the host epithelial cell provides insight into how host-bacterial interaction may lead to host disease.
Localization (translocation) of CagA in epithelial cell associated with disease
3) Confidence 0.78 Published 2002 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 11849122 Disease Relevance 0.64 Pain Relevance 0.11
Translocation of the CagA bacterial protein into gastric epithelial cells has been linked to an increased risk of peptic ulcer disease and gastric carcinoma.
Localization (Translocation) of CagA in epithelial cells associated with peptic ulcer disease, disease and stomach cancer
4) Confidence 0.78 Published 2007 Journal Cell. Microbiol. Section Abstract Doc Link 17217431 Disease Relevance 0.78 Pain Relevance 0.10
Three different phenotypes--production of vacuolating cytotoxin, presence of cagA, and ability for strong PMN activation--appear to be linked to one another and to the propensity for a H. pylori strain to cause peptic ulcer disease.
Localization (presence) of cagA associated with peptic ulcer disease, disease and sprains and strains
5) Confidence 0.73 Published 1995 Journal Ann. Med. Section Abstract Doc Link 8541032 Disease Relevance 0.71 Pain Relevance 0.14
Variation in the size of CagA is due to the presence of a variable number of repeat sequences located in the 3?
Localization (size) of CagA
6) Confidence 0.73 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2768901 Disease Relevance 0.72 Pain Relevance 0.07
Some studies have identified an association between the CagA-positive strains and the increased acid secretion that in turn leads to gastro-esophageal reflux.[71] The causative association between H. pylori and GORD needs further research for confirmation.


Localization (secretion) of CagA associated with gastroesophageal reflux disease and sprains and strains
7) Confidence 0.73 Published 2009 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC2702974 Disease Relevance 1.37 Pain Relevance 0.05
Can anti-Helicobacter pylori and anti-CagA antibodies be used to select patients with dyspepsia for gastroscopy?
Localization (used) of CagA associated with ulcers and nud
8) Confidence 0.73 Published 2006 Journal Trop Gastroenterol Section Title Doc Link 17310555 Disease Relevance 0.48 Pain Relevance 0.24
Upon translocation, CagA is tyrosine phosphorylated by Src family kinases (SFKs), which themselves become inactivated via a negative feedback loop.
Localization (translocation) of CagA
9) Confidence 0.73 Published 2007 Journal Cell. Microbiol. Section Abstract Doc Link 17217431 Disease Relevance 0.86 Pain Relevance 0.10
Clinical relevance of the cagA, vacA and iceA genotypes of Helicobacter pylori in Brazilian clinical isolates.
Localization (relevance) of cagA associated with ulcers
10) Confidence 0.73 Published 2003 Journal FEMS Immunol. Med. Microbiol. Section Title Doc Link 12738389 Disease Relevance 1.71 Pain Relevance 0.36
Overall, we found that it is largely true that CagA with sequences segments C and D are related to Western and East Asian countries, respectively; however, there are some exceptions for East Asian strains.
Localization (related) of CagA associated with sprains and strains
11) Confidence 0.73 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2768901 Disease Relevance 0.35 Pain Relevance 0
Besides the babA2+ genotype this clinical isolate also presented cagA+ and vacAs1a which has been related with metaplasia or gastric cancer.
Localization (presented) of cagA
12) Confidence 0.68 Published 2006 Journal Rev Med Chil Section Body Doc Link 17130985 Disease Relevance 0.27 Pain Relevance 0
The aim of the present study was to analyze such an association of cagA presence and vacA subtypes of H. pylori with histopathological findings in patients with gastritis.
Spec (analyze) Localization (presence) of cagA associated with gastritis
13) Confidence 0.68 Published 2006 Journal J. Gastroenterol. Hepatol. Section Abstract Doc Link 16724992 Disease Relevance 0.55 Pain Relevance 0.10
The cag PAI encodes a type IV secretion system, by which CagA proteins are delivered into host cells [26–30].
Localization (secretion) of CagA
14) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2768901 Disease Relevance 0.18 Pain Relevance 0
Two other S100 proteins (S100A8 and S100A9, respectively named myeloid-related protein [MRP]8 and MRP14), which are found in both infiltrating PMCs and monocytes, were recently described in different types of inflammatory arthritis [36-40].
Localization (found) of S100A8 in monocytes associated with inflammation and arthritis
15) Confidence 0.44 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174942 Disease Relevance 1.77 Pain Relevance 0.84

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